Involvement of RAGE and Oxidative Stress in Inflammatory and Infectious Skin Diseases

Guarneri, Fabrizio; Custurone, Paolo; Papaianni, Valeria; Gangemi, Sebastiano

doi:10.3390/antiox10010082

Cited by 37 publications

(25 citation statements)

References 61 publications

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“…It seems that S100A6 binding activates the NF-kB pathway and leads to apoptosis [ 18 ]. RAGE are known to be associated with various inflammatory cutaneous diseases (both autoimmune and infectious) [ 19 ]. RAGE pathway was reported to be involved in Ssc ulcerations development [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

S100A6, Calumenin and Cytohesin 2 as Biomarkers for Cutaneous Involvement in Systemic Sclerosis Patients: A Case Control Study

Bălănescu

Băicuș

et al. 2021

JPM

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Background: Systemic sclerosis (Ssc) is an autoimmune disease with incomplete known physiopathology. There is a high number of candidate proteomic biomarkers for Ssc that have not yet been confirmed on independent Ssc cohorts. The aim of the study was to confirm circulating S100A6, calumenin, and cytohesin 2 as biomarkers for Ssc. Methods: 53 Ssc patients and 26 age- and gender-matched controls were included. Serum S100A6, calumenin, and cytohesin 2 were evaluated with commercial ELISA kits. Associations between serum expression and clinical Ssc characteristics were evaluated. Results: Serum calumenin, S100A6, and cytohesin 2 were higher in Ssc patients compared to controls. Calumenin associated with extensive cutaneous fibrosis, frequency of Raynaud phenomenon, and low complement level, and had a tendency to be higher in Ssc patients with pulmonary fibrosis. S100A6 correlated with the number of active digital ulcers. Serum cytohesin 2 levels were higher in patients with teleangiectasia and associated with pulmonary artery pressure. Conclusions: Serum calumenin, S100A6, and cytohesin 2 were confirmed as biomarkers on an independent group of Ssc patients. Calumenin had the best predictive capacity for cutaneous Ssc manifestations. Future studies are needed to evaluate the prognostic value of these biomarkers and evaluate them as possible therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

S100A6, Calumenin and Cytohesin 2 as Biomarkers for Cutaneous Involvement in Systemic Sclerosis Patients: A Case Control Study

Bălănescu

Băicuș

et al. 2021

JPM

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“…Emerging evidence suggests that OS is involved in the pathophysiological pathways of several disorders, such as cardiovascular diseases, retinal degeneration, benign prostatic hyperplasia, diabetic disease, asthma, and neurodegenerative diseases [4][5][6]. As mentioned above, OS also plays a role in the pathogenesis of chronic skin diseases [7,8] and in the transformation and progression of skin cancers, in particular melanoma [9].…”

Section: Oxidative Stress Involvementmentioning

confidence: 94%

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

et al. 2021

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Oxidative stress plays an important pathogenetic role in many chronic inflammatory diseases, including those of dermatological interest. In particular, regarding psoriasis, vitiligo, and lichen planus, excess reactive oxygen species and a decline in endogenous antioxidant systems are observed. In this regard, treatments with antioxidant properties could be appropriate therapeutic options. To date, clinical trials in dermatology on these treatments are limited. We reviewed the available studies on the efficacy of antioxidant therapies in psoriasis, vitiligo, and lichen planus. The role of herbal derivatives, vitamins, and trace elements was analyzed. The antioxidant properties of conventional therapies were also evaluated. Data from the literature suggest that antioxidants might be useful, but available studies on this topic are limited, heterogeneous, not completely standardized, and on small populations. Furthermore, in most cases, antioxidants alone are unable to induce significant clinical changes, except perhaps in mild forms, and must be used in conjunction with standard drug treatments to achieve measurable results. Further studies need to be conducted, considering larger populations and using internationally validated scales, in order to compare the results and clinical efficacy.

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“…Recent years have seen increasing research interest in oxidative stress (OS) in the pathogenesis of several diseases, such as inflammatory, chronic degenerative (Alzheimer's disease), cardiovascular, or autoimmune [5][6][7][8]. OS modifies the normal intracellular balance, producing excessive oxidant substances, i.e., reactive oxygen species (ROS) and reactive nitrogen species (RNS) and resulting in a relative deficiency of enzymatic and nonenzymatic antioxidants [9,10].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review and Meta‐Analysis of Oxidative Stress and Antioxidant Markers in Oral Lichen Planus

Wang

Yang

Wang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Background. Oral lichen planus (OLP) is a relatively common chronic inflammatory disease of unknown etiology, which might be caused by oxidative stress and impaired antioxidant defense. Objective. To systematically investigate the markers of oxidative stress and antioxidant systems in the saliva and blood from OLP patients and healthy controls. Methods. The PubMed, Cochrane Library, and Embase were systematically queried to collect data from studies in which oxidative stress/antioxidant markers from OLP and healthy subjects had been evaluated until March 10, 2021. Results. A total of 28 studies fulfilled inclusion criteria, and 25 of them, having 849 OLP patients and 1,052 control subjects and analyzing 12 oxidative stress and antioxidant state marker levels, were subjected to meta-analysis. We found a significant decrease in total antioxidant capacity (TAC) and uric acid (UA) and a significant increase in malondialdehyde (MDA) and nitric oxide (NO) levels in the saliva and serum/plasma of OLP patients. Moreover, a significant elevation of 8-hydroxy-deoxyguanosine (8-OHdG) and advanced oxidation protein product (AOOP) level and a decrease in vitamin C were also observed in the saliva of the OLP group. In contrast, salivary vitamin A, zinc, glutathione peroxidase (GPx), vitamin E, and nitrite were not significantly different between the two groups. In single studies, markers of oxidative stresses such as superoxide dismutase (SOD) and 8-isoprostanelevels were elevated in OLP, and antioxidant parameters such as glutathione (GSH) and total protein (TP) levels were dysregulated. Conclusion. This meta-analysis helps to clarify the profile of oxidative stress and antioxidant state markers in OLP patients although existing evidence is rather heterogeneous and many studies are affected by several limitations. Larger and more standardized studies are warranted to ascertain whether these markers are potential causes or effects of OLP and whether antioxidant therapy improving oxidative stress will be useful.

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Involvement of RAGE and Oxidative Stress in Inflammatory and Infectious Skin Diseases

Cited by 37 publications

References 61 publications

S100A6, Calumenin and Cytohesin 2 as Biomarkers for Cutaneous Involvement in Systemic Sclerosis Patients: A Case Control Study

S100A6, Calumenin and Cytohesin 2 as Biomarkers for Cutaneous Involvement in Systemic Sclerosis Patients: A Case Control Study

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

Systematic Review and Meta‐Analysis of Oxidative Stress and Antioxidant Markers in Oral Lichen Planus

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