Involvement of sensory fibres in axonal subtypes of Guillain-Barre syndrome

Capasso, Margherita; Notturno, Francesca; Manzoli, Claudia; Uncini, Antonino

doi:10.1136/jnnp.2010.238311

Cited by 75 publications

(60 citation statements)

References 47 publications

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“…Based on these findings, it has been proposed that axonal GBS could be pathophysiologically characterized by axonal degeneration or reversible conduction failure at the Ranvier node [23]. Moreover, reversible conduction failure has also been documented in the sensory nerves in different subtypes of axonal GBS [24]. In one recently published paper, reversible conduction failure in the sensory nerves was documented in 3 patients with pure FS [25].…”

Section: Discussionmentioning

confidence: 99%

Sensory Conduction Study in Fisher Syndrome: Patterns of Abnormalities and Their Clinical Correlation

Lyu

Chang²,

Chu³

et al. 2013

Eur Neurol

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Objective: To report sensory conduction findings in patients with typical Fisher syndrome (FS) and to determine if a specific pattern of sensory conduction abnormalities was present in such patients. Methods: We retrospectively reviewed results of sensory conduction studies of 55 FS patients and compared them with those obtained from 83 age- and sex-matched healthy volunteers. Results: Mean median and ulnar sensory nerve action potential (SNAP) amplitudes were lower in FS patients than in normal subjects, whereas sural SNAP amplitudes were not different between the two groups. Abnormal median/ulnar sensory responses (reduced SNAP amplitude or absent response) were more frequently observed than abnormal sural response. Normal sensory conduction results were found in 31 (56%) patients. Of the 24 (44%) patients with abnormal sensory findings, 18 (33%) had a sural-sparing pattern of abnormalities. Patients with impaired sensation had lower median and ulnar SNAP amplitudes than those without. Conclusions: Abnormal median and ulnar sensory responses were the most frequent sensory findings in FS. Findings of the sural-sparing pattern of abnormalities suggest distal sensory nerve involvement in these patients.

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Section: Discussionmentioning

confidence: 99%

Sensory Conduction Study in Fisher Syndrome: Patterns of Abnormalities and Their Clinical Correlation

Lyu

Chang²,

Chu³

et al. 2013

Eur Neurol

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“…The extraocular muscles are spared. There are no sensory features although mild changes in sensory nerves may occur [ 83 ] . The condition occurs as an annual epidemic during summer months.…”

Section: Acute Motor Axonal Neuropathy (Aman)mentioning

confidence: 99%

“…Anti-GM1, antiGM1b, and anti-GD1a, immunological markers for AMAN, are seen in high percentage of patients with AMSAN [ 93 ] . Also, sensory fi ber involvement which distinguishes AMSAN from AMAN has been shown to be often involved subclinically in AMAN patients [ 83 ] .…”

Section: Acute Motor-sensory Axonal Neuropathy (Amsan)mentioning

confidence: 99%

“…AIDP, AMAN, and AMSAN may have similar fi ndings during the fi rst weeks of illness. As outlined above, sensory conduction abnormalities are seen in patients with AMAN, making the distinction with AMSAN sometimes dif fi cult [ 83 ] . Also, transient conduction slowing and block may be encountered during the early stages of AMAN, leading to incorrect diagnosis of AIDP [ 106,117 ] .…”

Section: Electrodiagnostic Studies In Gbs Subtypesmentioning

confidence: 99%

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Guillain-Barré Syndrome and Related Disorders

Piccione

Salame

Katirji

2013

Neuromuscular Disorders in Clinical Practice

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“…There are several types of polyneuropathies: axonal, demyelinating [1] and those associated with metabolic changes [2]. Polyneuropathy may selectively affect either heavily myelinated Aα and Aβ nerve fibers or thin Aδ and C nerve fibers [3], or be restricted to either motor or sensory nerve fibers [4]. It is thus essential to investigate the possible alteration in every nerve fiber group ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%