Involvement of serum glucocorticoid‐regulated kinase 1 in reproductive success

Abstract

Reproductive processes, in particular events that concern pregnancy, are fine-tuned to produce offspring. Reproductive success is of prime importance for the survival of every species. The highly conserved and ubiquitously expressed serum glucocorticoid-regulated kinase 1 (SGK1) was first implicated in infertility as a regulator of a Na channel. In this review, we emphasize the prominent role of SGK1 during early pregnancy: 1) balancing uterine luminal fluid secretion and reabsorption to aid blastocyst adhesion and to import nutrients and energy; 2) transducing signals from the blastocyst to the receptive endometrium; 3) inducing multiple genes that are involved in uterine receptivity and trophoblast invasion; 4) regulating cell differentiation and antioxidant defenses at the fetomaternal interface; and 5) contributing to the proliferation and survival of decidual stromal cells. Accordingly, SGK1 coordinates many cellular processes that are crucial to reproductive activities. Aberrant expression or function of SGK1 results in implantation failure and early pregnancy loss. Further investigation of the molecular mechanisms of the function of SGK1 might provide novel diagnostic tools and interventions for reproductive complications.-Lou, Y., Hu, M., Mao, L., Zheng, Y., Jin, F. Involvement of serum glucocorticoid-regulated kinase 1 in reproductive success.

Decidualization of the human endometrium

“…Intensive immunostaining for copper, zinc, and manganese‐SOD has been found in decidualized ESCs in early pregnancy . Progesterone drives the expression of serum‐ and glucocorticoid‐inducible kinase‐1 (SGK1) in the decidualizing stromal cells . In pregnancy, endometrial SGK1 activity safeguards the decidual–placental interface against oxidative stress signals that are generated in response to intense tissue remodeling, the influx of inflammatory cells, and dynamic changes in local perfusion and oxygen tension.…”

“…67 Progesterone drives the expression of serum-and glucocorticoid-inducible kinase-1 (SGK1) in the decidualizing stromal cells. 68,69 In pregnancy, endometrial SGK1 activity safeguards the decidual-placental interface against oxidative stress signals that are generated in response to intense tissue remodeling, the influx of inflammatory cells, and dynamic changes in local perfusion and oxygen tension. These findings suggest that endometrial decidualization regulates embryo invasion and tissue homeostasis and presents resistance to oxidative stress.…”

Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?

“…A similar observation is reported in other studies after the consumption of melatonin-rich foods such as walnuts, olive oil, wine, fruits and legumes as well as germinated kidney beans (Peuhkuri et al, 2012 ; Johns et al, 2013 ; Sae-Teaw et al, 2013 ; Tan et al, 2014 ; Aguilera et al, 2016 ). However, it remains unclear whether the acute variation of circulating melatonin levels induced by the consumption of melatonin-rich foods correlates with their influence on the cardiovascular system (Bazzano et al, 2001 ; Al Abdrabalnabi et al, 2017 ; Aune et al, 2017 ; Micha et al, 2017 ). The evidence for cardiovascular benefits of some melatonin containing foods including, walnuts, tropical fruits and grape products are reviewed below.…”

Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via IL‑1β and the SGK1‑NFAT2 signaling pathway

“…Serum/glucocorticoid regulated kinase 1 (SGK1), a kinase under powerful genomic regulation and activated by phosphorylation via the phosphoinositol-3-phosphate signaling pathway, has been reported to regulate several enzymes and transcription factors. SGK1 contributes to the regulation of transport, hormone release, neuroexcitability, inflammation, cell proliferation and apoptosis (7,8). our previous study revealed that different cyclic hydrodynamic pressures display different effects on promoting the proliferation of human BSMcs (HBSMcs) cultured in scaffolds via the Pi3K/SGK1 signaling pathway (9).…”