2000
DOI: 10.1038/sj.onc.1203254
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Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF

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Cited by 54 publications
(47 citation statements)
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“…195 Lyn-deficient DT40 cells expressing G-CSF receptor showed impaired responsiveness to G-CSF, manifested by reduced phosphorylation of Cbl, Shc, Gab2 and PI3K, and reduced DNA synthesis compared to wild-type cells. 196,197 Ectopic expression of Lyn restored the G-CSF-dependent proliferative responses of these cells. 198 The promotion of cell survival by SFKs is probably brought about by the activation of downstream signaling molecules such as PI3K/Akt and STATs which are known to phosphorylate and inactivate proapoptotic Bad protein and increase the expression of antiapoptotic Bcl-X L protein, respectively.…”
Section: Src Family Kinasesmentioning
confidence: 99%
“…195 Lyn-deficient DT40 cells expressing G-CSF receptor showed impaired responsiveness to G-CSF, manifested by reduced phosphorylation of Cbl, Shc, Gab2 and PI3K, and reduced DNA synthesis compared to wild-type cells. 196,197 Ectopic expression of Lyn restored the G-CSF-dependent proliferative responses of these cells. 198 The promotion of cell survival by SFKs is probably brought about by the activation of downstream signaling molecules such as PI3K/Akt and STATs which are known to phosphorylate and inactivate proapoptotic Bad protein and increase the expression of antiapoptotic Bcl-X L protein, respectively.…”
Section: Src Family Kinasesmentioning
confidence: 99%
“…Activation of Shc has been linked to the MAPK (for a recent review see Ravichandran 35 ), PI3-K, 15 and Src family kinase pathways. 36 Gab2 activation also occurs through tyrosine 577, while a dominantnegative Gab2 suppresses PI3-K activation and proliferation of Ba/F3 cells in response to IL-3. 15 Importantly, mutation of this tyrosine to phenylalanine (Y577F) in the context of wild-type h␤c (while abolishing detectable Shc activation) does not significantly affect proliferation or viability of Ba/F3 cells in response to hGM-CSF.…”
Section: A Tyrosine-dependent Proliferation Signal Emanates From Tyr5mentioning
confidence: 99%
“…Signaling cascades involving Shc-Grb2-Ras-Erk, Cbl-PI 3-kinase, Fak-Paxillin-Tensin, or Vav-Rac GEF are associated with Src activation. [4][5][6][7][8][9][10][11][12][13] The Src-related kinase Lyn is found predominantly in B lymphocytes and myeloid cells. Lyn Ϫ/Ϫ mice display disturbed B-cell lymphopoiesis and autoimmunity, and defective mast cell degranulation.…”
Section: Introductionmentioning
confidence: 99%