Involvement of SIRT1 in amelioration of schistosomiasis-induced hepatic fibrosis by genistein

Zhou, Cao; Li, Dan; Ding, Cairong; Yuan, Qiulin; Yu, Shanshan; Du, Debing; Huang, Weifeng; Wang, Decheng

doi:10.1016/j.actatropica.2021.105961

Cited by 10 publications

(6 citation statements)

References 36 publications

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“…Treatment with genistein also reduced oxidative stress during neuronal injury by modulation of Nrf2 signaling [ 21 , 22 ]. Further, genistein treatment also enhanced SIRT1 expression in schistosomiasis-induced hepatic fibrosis that led to protective effect via α-SMA and TGF-β expression down-regulation [ 23 ]. Genistein-induced SIRT1 expression also down regulates osteopontin expression [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

et al. 2021

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Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsible for the multifaceted nature of cancer. Recent advances in the field of next generation sequencing and functional genomics have brought us closer towards unravelling the complexities of tumor microenvironment (tumor heterogeneity) and deregulated signaling cascades responsible for proliferation and survival of tumor cells. Phytochemicals have begun to emerge as potent beneficial substances aimed to target deregulated signaling pathways. Isoflavonoid genistein is an essential phytochemical involved in regulation of key biological processes including those in different types of cancer. Emerging preclinical evidence have shown its anti-cancer, anti-inflammatory and anti-oxidant properties. Testing of this substance is in various phases of clinical trials. Comprehensive preclinical and clinical trials data is providing insight on genistein as a modulator of various signaling pathways both at transcription and translation levels. In this review we have explained the mechanistic regulation of several key cellular pathways by genistein. We have also addressed in detail various microRNAs regulated by genistein in different types of cancer. Moreover, application of nano-formulations to increase the efficiency of genistein is also discussed. Understanding the pleiotropic potential of genistein to regulate key cellular pathways and development of efficient drug delivery system will bring us a step towards designing better chemotherapeutics.

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Section: Introductionmentioning

confidence: 99%

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

et al. 2021

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“…The same concentration of genistein reversed the reduction of STRT1 expression and activity in schistosome liver fibrosis tissues. By suppressing SIRT1 activity, 5–10 and 20 µM doses of genistein significantly decreased HSC-T6 cell activation ( Zhou C. et al, 2021 ). Previous studies have demonstrated that genistein attenuates hepatic fibrosis by inhibiting TGF-β/Smad signaling through downregulation of p-Smad3 ( Ganai and Husain, 2017 ).…”

Section: Natural Products Against Schistosomiasis-associated Liver Fi...mentioning

confidence: 99%

Therapeutic potential of natural products in schistosomiasis-associated liver fibrosis

Liu,

Fisher,

Pronyuk

et al. 2024

Front. Pharmacol.

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Schistosomiasis is a parasitic disease that endangers human health and social development. The granulomatous reaction of Schistosoma eggs in the liver is the main cause of hepatosplenomegaly and fibrotic lesions. Anti liver fibrosis therapy is crucial for patients with chronic schistosomiasis. Although Praziquantel is the only clinical drug used, it is limited in insecticide treatment and has a long-term large-scale use, which is forcing the search for cost-effective alternatives. Previous research has demonstrated that plant metabolites and extracts have effective therapeutic effects on liver fibrosis associated with schistosomiasis. This paper summarizes the mechanisms of action of metabolites and some plant extracts in alleviating schistosomiasis-associated liver fibrosis. The analysis was conducted using databases such as PubMed, Google Scholar, and China National Knowledge Infrastructure (CNKI) databases. Some plant metabolites and extracts ameliorate liver fibrosis by targeting multiple signaling pathways, including reducing inflammatory infiltration, oxidative stress, inhibiting alternate macrophage activation, suppressing hepatic stellate cell activation, and reducing worm egg load. Natural products improve liver fibrosis associated with schistosomiasis, but further research is needed to elucidate the effectiveness of natural products in treating liver fibrosis caused by schistosomiasis, as there is no reported data from clinical trials in the literature.

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“…In schistosomiasis-induced liver fibrosis mice, genistein markedly reduces the levels of collagens or expression of α-smooth muscle actin, exhibiting its antifibrosis effect [158,159]. This above effect is mainly caused by the inhibition of NFκB signaling, the regulation of cytokines, or the upregulation of the nicotinamide adenine dinucleotide-dependent histone deacetylase SIRT1 [158,159]. Furthermore, genistein could improve alcohol-induced liver fibrosis in rodents via its antioxidation, anti-inflammation, proapoptosis of HSCs and antiapoptosis of hepatocytes [100,160].…”

Section: Genisteinmentioning

confidence: 99%

“…3a), is readily obtained from soybean and shows a remarkable protective effect against liver damage [157]. In schistosomiasis-induced liver fibrosis mice, genistein markedly reduces the levels of collagens or expression of α-smooth muscle actin, exhibiting its antifibrosis effect [158,159]. This above effect is mainly caused by the inhibition of NFκB signaling, the regulation of cytokines, or the upregulation of the nicotinamide adenine dinucleotide-dependent histone deacetylase SIRT1 [158,159].…”

Section: Natural Compounds Derived From Edible Plantsmentioning

confidence: 99%

A review of edible plant-derived natural compounds for the therapy of liver fibrosis

Wang

Niu

et al. 2022

European Journal of Gastroenterology &Amp; Hepatology

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Liver fibrosis has a high incidence worldwide and is the common pathological basis of many chronic liver diseases. Liver fibrosis is caused by the excessive deposition of extracellular matrix and concomitant collagen accumulation in livers and can lead to the development of liver cirrhosis and even liver cancer. A large number of studies have provided evidence that liver fibrosis can be blocked or even reversed by appropriate medical interventions. However, the antifibrosis drugs with ideal clinical efficacy are still insufficient. The edible plant-derived natural compounds have been reported to exert effective antifibrotic effects with few side-effects, representing a kind of promising source for the treatment of liver fibrosis. In this article, we reviewed the current progress of the natural compounds derived from dietary plants in the treatment of liver fibrosis, including phenolic compounds (capsaicin, chlorogenic acid, curcumin, ellagic acid, epigallocatechin-3-gallate, resveratrol, sinapic acid, syringic acid, vanillic acid and vitamin E), flavonoid compounds (genistein, hesperidin, hesperetin, naringenin, naringin and quercetin), sulfur-containing compounds (S-allylcysteine, ergothioneine, lipoic acid and sulforaphane) and other compounds (betaine, caffeine, cucurbitacin B, lycopene, α-mangostin, γ-mangostin, ursolic acid, vitamin C and yangonin). The pharmacological effects and related mechanisms of these compounds in in-vivo and in-vitro models of liver fibrosis are focused.

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Involvement of SIRT1 in amelioration of schistosomiasis-induced hepatic fibrosis by genistein

Cited by 10 publications

References 36 publications

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

Therapeutic potential of natural products in schistosomiasis-associated liver fibrosis

A review of edible plant-derived natural compounds for the therapy of liver fibrosis

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