Involvement of Soluble Adhesion Molecules in Acute Pancreatitis

Nakae, Hajime; Endo, Shunsuke; Sato, Nobuhiro; Wakabayashi, Go; Inada, Katsuya; Sato, Shigehiro

doi:10.1159/000049733

Cited by 17 publications

(14 citation statements)

References 17 publications

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“…Moreover, during 3 days from admission, E-selectin concentrations were increasing in severe disease in contrast to mild AP [132]. Nakae et al [133] observed positive correlation between soluble E-selectin and TNF-α in the early phase of human AP; both mediators were positively associated with AP severity. Hynninen et al [134] reported similarly increased soluble E-selectin in patients with SAP and with severe sepsis, positively correlated with SOFA scores.…”

Section: Laboratory Markers Of Endothelial Activation and Injury Imentioning

confidence: 99%

“…In this study, strong positive correlations were observed between plasma-soluble ICAM-1 and severity of organ dysfunction (APACHE III and SOFA scores) in SAP patients. Nakae et al [133] observed higher soluble ICAM-1 in patients who died from AP than in survivors.…”

Section: Laboratory Markers Of Endothelial Activation and Injury Imentioning

confidence: 99%

“…Serum VCAM-1 in AP patients on admission was lower than in controls and did not correlate with AP severity in one study [123], while it was higher among non-survivors of SAP and positively correlated with ICAM-1 and TNF-α in another study [133]. …”

Section: Laboratory Markers Of Endothelial Activation and Injury Imentioning

confidence: 99%

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The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications

Dumnicka

Maduzia

Ceranowicz

et al. 2017

IJMS

160

113

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Acute pancreatitis (AP) is an inflammatory disease with varied severity, ranging from mild local inflammation to severe systemic involvement resulting in substantial mortality. Early pathologic events in AP, both local and systemic, are associated with vascular derangements, including endothelial activation and injury, dysregulation of vasomotor tone, increased vascular permeability, increased leukocyte migration to tissues, and activation of coagulation. The purpose of the review was to summarize current evidence regarding the interplay between inflammation, coagulation and endothelial dysfunction in the early phase of AP. Practical aspects were emphasized: (1) we summarized available data on diagnostic usefulness of the markers of endothelial dysfunction and activated coagulation in early prediction of severe AP; (2) we reviewed in detail the results of experimental studies and clinical trials targeting coagulation-inflammation interactions in severe AP. Among laboratory tests, d-dimer and angiopoietin-2 measurements seem the most useful in early prediction of severe AP. Although most clinical trials evaluating anticoagulants in treatment of severe AP did not show benefits, they also did not show significantly increased bleeding risk. Promising results of human trials were published for low molecular weight heparin treatment. Several anticoagulants that proved beneficial in animal experiments are thus worth testing in patients.

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Section: Laboratory Markers Of Endothelial Activation and Injury Imentioning

confidence: 99%

Section: Laboratory Markers Of Endothelial Activation and Injury Imentioning

confidence: 99%

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The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications

Dumnicka

Maduzia

Ceranowicz

et al. 2017

IJMS

160

113

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“…Acute pancreatitis causes a release of various inflammatory mediators, attracts inflammatory cells to the vascular endothelium and induces the expression of adhesion molecules (1,24). Studies have shown that NF-κB plays a critical role in the development of acute pancreatitis (25,26).…”

Section: Discussionmentioning

confidence: 99%

Effects of thymosin β4 on a rat model of severe acute pancreatitis

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the effects of thymosin β4 on a rat model of severe acute pancreatitis (SAP) induced by sodium taurocholate (STC) and the underlying mechanism. SAP was induced by the retrograde infusion of 5% STC (1 ml/kg) into the bile-pancreatic duct. In certain rats, thymosin β4 (30 mg/kg) was administered intraperitoneally 30 min prior to the infusion of STC. The severity of pancreatitis was evaluated by the measurement of serum amylase, lipase, tumor necrosis factor-α, interleukin (IL)-1β, IL-6 and myeloperoxidase (MPO) levels, and histological grading. Nuclear factor (NF)-κB activation was evaluated by immunohistochemistry and western blot analysis. Intercellular adhesion molecule (ICAM)-1 protein expression in the pancreas was studied using western blot analysis. Prophylactic administration of thymosin β4 was found to attenuate serum amylase and lipase activity and the serum concentrations of proinflammatory cytokines. In addition, it attenuated pathological pancreatic injury, pancreatic MPO activity, and the activation of NF-κB and ICAM-1 in the pancreas. These results suggest that thymosin β4 exerts a protective effect against STC-induced pancreatic injury. IntroductionAcute pancreatitis is an inflammatory disease of the pancreas characterized by acute abdominal pain and increased concentrations of serum amylase and lipase. In the majority of cases, it runs a mild course without complications. However, ~25% patients develop severe acute pancreatitis (SAP), which may result in systemic inflammatory response syndrome and subsequent multiple organ dysfunction syndrome, and the mortality rate is up to 40% (1,2). In recent years, many investigators have attempted to reveal the pathogenesis of acute pancreatitis; however, the exact mechanisms are not well understood. Accumulating evidence indicates that SAP is closely associated with tissue injury and microcirculation disorders resulting from the production of proinflammatory cytokines and mediators, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and intercellular adhesion molecule (ICAM)-1 (3,4). In addition, studies have shown that acute pancreatitis can lead to activation of the nuclear factor (NF)-κB signaling pathway (5,6). Therefore, reducing the levels of proinflammatory cytokines and adhesion molecules to block the inflammatory cascade may be a valid treatment strategy for acute pancreatitis.Thymosin β4 is a highly conserved polypeptide that was originally isolated from bovine thymus gland extract in 1981 (7). Thymosin β4 contains 43-amino acid residues with a molecular weight of 4964.5 Da and an isoelectric point of 4.6 (8). It is widely distributed in many tissues and cell types and is found in high concentrations in blood platelets, macrophages and white blood cells, but not in red blood cells (9). The most prominent physiological role of thymosin β4 as the major actin-sequestering peptide contributes to the regulation of actin polymerization in mammalian nucleated cells (10). There is g...

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“…Furthermore, in acute pancreatitis and severe burn, serum levels of sICAM-1 and sVCAM-1 have been shown to reflect the severity of the disease and be associated with the prognosis [5,6]. …”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Soluble Adhesion Molecules as Prognostic Factors for Acute Liver Failure

et al. 2012

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Background/Aims: In patients with septic shock, the degree of liver dysfunction is correlated with serum levels of soluble intercellular adhesion molecule (sICAM)-1. We aimed to assess the usefulness of serum levels of soluble adhesion molecules as prognostic factors for acute liver failure (ALF). Methods: Serum levels of soluble platelet endothelial cell adhesion molecule (sPECAM)-1, sICAM-3, soluble endothelial (sE) selectin, sICAM-1, soluble platelet selectin, and soluble vascular cell adhesion molecule-1 on admission were measured in 37 ALF patients and 34 healthy controls. Results: Twenty-two ALF patients (59%) reached to fatal outcomes. Serum levels of sPECAM-1, sICAM-3, sE-selectin and sICAM-1 were higher in ALF patients than healthy controls. In 37 ALF patients, by the multivariate logistic regression analysis, ratio of direct to total bilirubin (per 0.1 increase; OR 0.11, 95% CI 0.01–0.99), serum sPECAM-1 level (per 100 ng/ml increase; OR 4.37, 95% CI 1.23–15.5) and serum sICAM-1 level (per 100 ng/ml increase; OR 0.49, 95% CI 0.27–0.89) were associated with fatal outcomes. Using receiver operating characteristics curve, each area under the curve of serum sPECAM-1 and sICMA-1 levels as prognostic factors was 0.71 and 0.74, respectively. Conclusion: Serum sPECAM-1 and sICAM-1 levels may be useful for predicting the prognosis of ALF.

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Involvement of Soluble Adhesion Molecules in Acute Pancreatitis

Cited by 17 publications

References 17 publications

The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications

The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications

Effects of thymosin β4 on a rat model of severe acute pancreatitis

Serum Levels of Soluble Adhesion Molecules as Prognostic Factors for Acute Liver Failure

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