Involvement of spinal 5-HT1A receptors in isolation rearing-induced hypoalgesia in mice

Horiguchi, Naotaka; Ago, Yukio; Asada, Kazuki; Kita, Yuki; Hiramatsu, Naoki; Takuma, Kazuhiro; Matsuda, Takehisa

doi:10.1007/s00213-012-2959-7

Cited by 17 publications

(13 citation statements)

References 56 publications

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“…The delayed recognition of acute illnesses and/or failure to respond to pain cues results in increased morbidity and mortality in patients with schizophrenia. Consistent with the clinical reports, social isolation rearing in mice after weaning reduces pain sensitivity to acute thermal and chemical (acetic acid and capsaicin) noxious stimuli (27) and inhibits FCA-induced mechanical allodynia (28). Regarding the underlying mechanisms, we have demonstrated that isolation rearing causes neuronal activation of the anterior cingulate cortex, periaqueductal gray matter, and rostral ventromedial medulla, but not the locus coeruleus, in mice and that intrathecal injection of WAY100635 alleviated hypoalgesia in capsaicin-induced nociception and inhibition of mechanical allodynia in isolation-reared mice (27,28).…”

Section: Hypoalgesiasupporting

confidence: 84%

“…Consistent with the clinical reports, social isolation rearing in mice after weaning reduces pain sensitivity to acute thermal and chemical (acetic acid and capsaicin) noxious stimuli (27) and inhibits FCA-induced mechanical allodynia (28). Regarding the underlying mechanisms, we have demonstrated that isolation rearing causes neuronal activation of the anterior cingulate cortex, periaqueductal gray matter, and rostral ventromedial medulla, but not the locus coeruleus, in mice and that intrathecal injection of WAY100635 alleviated hypoalgesia in capsaicin-induced nociception and inhibition of mechanical allodynia in isolation-reared mice (27,28). These findings suggest that the spinal 5-HT 1A receptor activation via the descending serotonergic inhibitory pathway contributes to isolation rearing-induced hypoalgesia and reduced pain sensitivity to tactile stimulation under conditions of chronic inflammatory pain (Fig.…”

Section: Hypoalgesiasupporting

confidence: 84%

“…We have found that osemozotan inhibited capsaicininduced nociception (licking behavior) (27) and Freund's complete adjuvant (FCA)-induced mechanical allodynia (28) in mice. These effects were completely blocked by the intrathecal injection of WAY100635.…”

Section: Hypoalgesiamentioning

confidence: 99%

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The Potential Role of Serotonin1A Receptors in Post-weaning Social Isolation–Induced Abnormal Behaviors in Rodents

2014

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Abstract. Post-weaning social isolation in mice induces behavioral abnormalities such as hyperactivity, aggression, depression-and anxiety-like behaviors, deficits of prepulse inhibition, and reduced pain sensitivity to the noxious stimuli. Then, this mouse is considered to be a model of psychiatric disorders including schizophrenia. We have found that serotonin (5-HT) 1A -receptor ligands attenuate these abnormalities, suggesting the pharmacological role of the receptor in treatment of psychiatric disorders. Furthermore, we have recently found that isolation-reared mice show social encounter-induced hyperactivity, a novel phenotype of the abnormal behaviors, and the hyperactivity is triggered by activation of the serotonergic system from the dorsal raphe to the frontal cortex. This review summarizes the effects of 5-HT 1A receptor ligands on aggressive behavior, deficits of prepulse inhibition, reduced pain sensitivity to the noxious stimuli, and encounter-induced hyperactivity in social isolation-reared mice. These findings suggest that the 5-HT 1A receptor is a potential target molecule for treatment of psychiatric disorders and pain.

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Section: Hypoalgesiasupporting

confidence: 84%

Section: Hypoalgesiasupporting

confidence: 84%

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The Potential Role of Serotonin1A Receptors in Post-weaning Social Isolation–Induced Abnormal Behaviors in Rodents

2014

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“…Ethanol directly activates the transient receptor potential vanilloid 1 (TRPV1), a heat-gated nociceptor also activated by spicy foods containing capsaicin (Trevisani et al 2002), which induces an aversive/painful burning sensation in the mouth and the periphery. Mice reared in isolation have impaired TRPV1 nociception across multiple measures compared to group-reared controls (Horiguchi et al 2013). Reduction in temperature-related pain sensitivity is also found in isolated rats (Petrovszki et al 2013).…”

Section: Discussionmentioning

confidence: 93%

Differential rearing alters taste reactivity to ethanol, sucrose, and quinine

et al. 2019

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Rationale-Early-life environment influences reinforcer and drug motivation in adulthood; however, the impact on specific components of motivation, including hedonic value ("liking"), remains unknown.Objectives-The current study determined whether differential rearing alters liking and aversive responding to ethanol, sucrose, and quinine in an ethanol-naïve rat model.Methods-Male and female rats were reared for 30 days starting at postnatal day 21 in either an enriched (EC), isolated (IC), or standard condition (SC). Thereafter, all rats had indwelling intraoral fistulae implanted and their taste reactivity to water, ethanol (5, 10, 20, 30, 40% v/v), sucrose (0.1, 0.25, 0.5 M), and quinine (0.1, 0.5 mM) was recorded and analyzed.Results-EC rats had higher amounts of liking responses to ethanol, sucrose, and quinine and higher amounts of aversive responses to ethanol and quinine compared to IC rats. While EC and IC rats' responses were different from each other, they both tended to be similar to SCs, who fell in between the EC and IC groups.Conclusions-These results suggest that environmental enrichment may enhance sensitivity to a variety of tastants, thereby enhancing liking, while isolation may dull sensitivity, thereby dulling liking. Altogether, the evidence suggests that isolated rats have a shift in the allostatic set-point which may, in part, drive increased responding for a variety of rewards including ethanol and sucrose. Enriched rats have enhanced liking of both sucrose and ethanol suggesting that enrichment may offer a unique phenotype with divergent preferences for incentive motivation.

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“…The MS protocol was performed for 2 hours (from 8 a.m. to 10 a.m.) from PND 12 until PND 21. The litters were removed from dams and placed in separate cages, somatosensory cortex and anterior cingulate cortex, has the potential to cause alterations in pain behavior (5,6). Cytoarchitecture changes in somatosensory areas are also associated with nociceptive sensitivity and chronic pain conditions (7).…”

Section: Ms Groupmentioning

confidence: 99%

Neonatal Sleep Restriction Increases Nociceptive Sensitivity in Adolescent Mice

et al. 2018

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Background: Sleep loss in infants may have a negative effect on the functional and structural development of the nociceptive system. We tested the hypothesis that neonatal sleep restriction induces a long-term increase of pain-related behaviors in mice and that this hypersensitivity occurs due to changes in the neuronal activity of nociceptive pathways. Objectives: We aim to investigate the effects of sleep loss in neonatal mice on pain behaviors of adolescent and adult mice in a sex-dependent manner. We also analyzed neuroanatomical and functional changes in pain pathways associated with behavioral changes. Study Design: An experimental animal study. Setting: A basic sleep research laboratory at Universidade Federal de São Paulo in Brazil. Methods: Neonatal mice at postnatal day (PND) 12 were randomly assigned to either control (CTRL), maternal separation (MS), or sleep restriction (SR) groups. MS and SR were performed 2 hours a day for 10 days (PND 12 until PND 21). The gentle handling method was used to prevent sleep. At PND 21, PND 35, or PND 90, the mice were tested for pain-related behaviors. Their brains were harvested and immunohistochemically stained for c-Fos protein in the anterior cingulate cortex, primary somatosensory cortex, and periaqueductal gray (PAG). Results: Neonatal SR significantly increased nociceptive sensitivity in the hot plate test in adolescent mice (-23.5% of pain threshold). This alteration in nociceptive response was accompanied by a decrease in c-Fos expression in PAG (-40% of c-Fos positive cells compared to the CTRL group). The hypersensitivity found in adolescent mice was not present in adult animals, and all mice showed a comparable nociceptive response. Limitations: Even using a mild manipulation method, in which a minimal amount of handling was applied to maintain wakefulness, sleep deprivation was a stressful event evidenced by higher corticosterone levels. Conclusion: Repeated exposures to sleep loss during early life were able to induce changes in the nociceptive response associated with alterations in neural activity in descending control of pain. Key words: Brain maturation, hypersensitivity, neuronal activity, nociception, pain, periaqueductal gray, postnatal development, sleep, sleep deprivation

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Involvement of spinal 5-HT1A receptors in isolation rearing-induced hypoalgesia in mice

Abstract: These findings suggest that isolation rearing causes hypoalgesia in mouse models of acute pain and imply that the spinal 5-HT1A receptor activation probably through descending serotonergic inhibitory pathway is involved in isolation rearing-induced hypoalgesia.

Cited by 17 publications

References 56 publications

The Potential Role of Serotonin1A Receptors in Post-weaning Social Isolation–Induced Abnormal Behaviors in Rodents

The Potential Role of Serotonin1A Receptors in Post-weaning Social Isolation–Induced Abnormal Behaviors in Rodents

Differential rearing alters taste reactivity to ethanol, sucrose, and quinine

Neonatal Sleep Restriction Increases Nociceptive Sensitivity in Adolescent Mice

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