Involvement of Th1Th17 Cell Subpopulations in the Immune Responses of Mothers Who Gave Birth to Children with Congenital Zika Syndrome (CZS)

Paiva, Iury Amâncio; Familiar-Macedo, Débora; Badolato-Corrêa, Jéssica; Carvalho, Fabiana Rabe; Dias, Helver Gonçalves; Pauvolid‐Corrêa, Alex; Santos, Caroline Ferreira dos; Silva, Andréa Alice; Azeredo, Elzinandes Leal de; Vianna, Renata Artimos de Oliveira; Cardoso, Claudete Aparecida Araújo; Grifoni, Alba; Sette, Alessandro; Weiskopf, Daniela; de-Oliveira-Pinto, Luzia Maria

doi:10.3390/v14020250

Cited by 1 publication

(2 citation statements)

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“…Familiar-Macedo et al 10.3389/fped.2023.1250059 data were like ours, considering that 66.7% of asymptomatic control children were positive to anti-measles IgG. However, higher than those found in children with CZS, which was 54.5%, and in those with DS, which was 55.9%.…”

Section: Discussionsupporting

confidence: 81%

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Serological investigation of vaccine-induced antibodies for measles, rubella, and yellow fever viruses in children vertically exposed to Zika virus or with down syndrome

Familiar-Macedo,

Dias,

Carvalho

et al. 2023

Front. Pediatr.

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BackgroundVaccination schedules, as well as their effectiveness and contraindications, need to be evaluated regularly, especially in specific situations. Congenital Zika Syndrome (CZS) is a severe condition that results in extensive functional and neurological impairment of fetuses and newborns due to Zika virus tropism for fetal neural progenitor cells. Down Syndrome (DS) is the leading genetic cause of intellectual disability. The immune impairment in DS has already been described, but little is known about the immune response of CZS children. Thus, CZS and DS are specific conditions that can be considered for a reassessment of the available immunizations. Here, we carried out serological analyses of attenuated vaccines-induced antibodies for measles, rubella, and yellow fever viruses in children aged 2–7, grouped into asymptomatic controls, DS children, and CZS children.MethodsPlasma samples were taken, and vaccination records were compiled during clinical follow-up. Enzymatic immunoassays for quantifying anti-measles and anti-rubella IgG were performed to assess the response to the Measles, Mumps, and Rubella (MMR) vaccine. Plaque Reduction Neutralization Test (PRNT) was performed to investigate neutralizing antibodies in response to the Brazilian vaccine strain of yellow fever (YF-17DD).ResultsWe highlight similar levels of anti-measles IgG and neutralizing antibodies for YF-17DD among CZS, DS, and asymptomatic children, although low positivity of measles data was seen in the three groups. In DS children, the 2–4-year-old group had an increased level of anti-measles IgG compared to the older group of children aged five to seven years. Lower anti-rubella IgG levels were observed in CZS and DS children compared to asymptomatic children. For anti-rubella IgG, the good performance of vaccination in asymptomatic children is due to younger ones rather than older ones.ConclusionsThere were no reports of adverse events after the use of the MMR and YF-17DD indicating that CZS and DS could continue to receive these vaccines, but our data draws attention to the necessity of monitoring the vaccination response in CZS and DS children over time and the possible need to adhere to national measles vaccination campaigns. Scientific research needs to continue to help develop appropriate CZS and DS health guidelines.

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Section: Discussionsupporting

confidence: 81%

“…Our group investigated a cohort of children between 2 and 3 years of age with a history of transplacental ZIKV infection. Only two of 17 children (12%) had ZIKV IgG and two of 15 (13%) had specific neutralizing antibodies for ZIKV ( 9 , 10 ). This seropositivity was much lower than we expected.…”

Section: Introductionmentioning

confidence: 99%