Involvement of the 5-HT1A and 5-HT1B serotonergic receptor subtypes in sexual arousal in male mice

Попова, Н. К.; Amstislavskaya, TG

doi:10.1016/s0306-4530(01)00097-x

Cited by 46 publications

(20 citation statements)

References 18 publications

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“…Serotonergic 5-HT 1A agonists − Mice: (Rodriguez-Manzo et al, 2002;Popova and Amstislavskaya, 2002) 5-HT 1B knockout mice were less impaired by serotonergic drugs, but needed more stimulation to ejaculate, possibly because of compensatory mechanisms (Rodriguez-Manzo et al, 2002).…”

Section: Effects Of Systemically Administered Drugs In Male Hamstersmentioning

confidence: 99%

Sexual behavior in male rodents

Hull

Domínguez

2007

Hormones and Behavior

395

272

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The hormonal factors and neural circuitry that control copulation are similar across rodent species, although there are differences in specific behavior patterns. Both estradiol (E) and dihydrotestosterone (DHT) contribute to the activation of mating, although E is more important for copulation and DHT for genital reflexes. Hormonal activation of the medial preoptic area (MPOA) is most effective, although implants in the medial amygdala (MeA) can also stimulate mounting in castrates. Chemosensory inputs from the main and accessory olfactory systems are the most important stimuli for mating in rodents, especially in hamsters, although genitosensory input also contributes. Dopamine agonists facilitate sexual behavior, and serotonin (5-HT) is generally inhibitory, though certain 5-HT receptor subtypes facilitate erection or ejaculation. Norepinephrine agonists and opiates have dose-dependent effects, with low doses facilitating and high doses inhibiting behavior.

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Section: Effects Of Systemically Administered Drugs In Male Hamstersmentioning

confidence: 99%

Sexual behavior in male rodents

Hull

Domínguez

2007

Hormones and Behavior

395

272

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“…Other studies show possible connections between serotonergic receptors and sexual hormones. Thus, in the presence of a sexually receptive female, the blood testosterone level increases in male mice; this effect is blocked by administering a 5HT‐ 1A receptor agonist [28,29]; the other antagonistic hormone, oestradiol, was reported to induce a desensitization of the 5HT‐ 1A receptors [30,31].…”

Section: The Role Of Serotonin In Sexual Reflexesmentioning

confidence: 99%

A dual physiological character for sexual function: the role of serotonergic receptors

Motofei

2007

BJU International

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Anatomically, sexual reflexes are mixed (somatic‐autonomic) circuits, represented by emission (sympathetic centre and somatic afferents), expulsion (parasympathetic centre and somatic efferents) and erection (parasympathetic centre and somatic afferents). Physiologically, ejaculation has a dual autonomic mediation, consisting of two distinct and opposite autonomic centres (emission and expulsion), both with a positive contribution to the respective function. Experimentally, serotonin (5HT) has two distinct, opposite and positive effects on sexual function, with 5HT‐1A agonists decreasing intravaginal ejaculatory latency and erection, and 5HT‐2C agonists increasing both erection and ejaculatory latency. In this review I assume that 5HT modulates sexual reflexes, establishing a functional connection between the involved somatic and autonomic structures. The 5HT‐1A receptors are assumed to make the connection between somatic pathways and sympathetic centres while the 5HT‐2C receptors could establish the connection between somatic pathways and parasympathetic centres. Further studies will develop the cerebral sexual duality, explaining the implication of psychological factors in sexual function and the role of sexuality in psychosocial behaviour.

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“…Серотонин считается медиатором, тесно связан-ным с реакцией на стресс (stress-related neurotransmitter) (Yamaguchi et al, 2016). Накоплены многочисленные дан-ные, свидетельствующие и об участии серотонина мозга в регуляции половых гормонов и в половой мотивации сам-цов (Науменко и др., 1983; Popova, Amstislavskaya, 2002).…”

Section: генетика поведенияunclassified

The domestication and the brain: forty years after

Попова¹

2017

Vestn. VOGiS

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The domestication of animals was crucial for the civilization evolutionary experiment. The main characteristic of domesticated animal is tame behavior towards man. D.K. Belyaev suggested that the domestication was carried out by man of the Stone Age as unintended selection of nonaggressive animals. This hypothesis was confirmed at the Institute of Cytology and Genetics, Novosibirsk, by unique long-lasting selection of silver foxes, Norway rats and American minks for nonaggressive behavior towards man. The review concentrates on the role of the brain neurotransmitters in the mechanism of animal domestication. Specifically, it describes the effect of selective breeding for nonaggressive behavior on the brain neurotransmitter serotonin (5-HT) system. Our data showed that produced by domestication the conversion of wild, aggressive animal to non-aggressive towards man is associated with changes in the expression of key molecular members determining the brain 5-HT system functioning. Significant difference between aggressive and nonaggressive animals in the 5-HT metabolism, in the expression of principle metabolic enzymes and 5-HT receptors was shown in different species of mammals (sil ver foxes, Norway rats and American minks). Higher concentration of 5-HT and its metabolite, 5-hydroxyindoleacetic acid, increased activity of the principle enzyme in 5-HT synthesis (tryptophan hydroxylase-2) and decreased activity of the principle enzyme in 5-HT degradation (monoamine oxidase A) was shown in the midbrain of domesticated silver foxes and rats. The expression of the 5-HTA receptor gene, the density and functional activity of 5-HTA receptors in nonaggressive rats were increased. The review provides converging lines of evidence for our hypothesis that the changes in the brain 5-HT contributes to a mechanism underlying correlative patterns of domestication, i.e. changes in the pivotal for stress response and for the reproduction pituitary-adrenal and pituitary-gonadal systems.Key words: domestication; aggressiveness; neurotransmitters; serotonin; correlative traits; stress-response; pituitary-gonadal system. Доместикация диких животных -краеугольный камень цивилиза-ции. Идея Д.К. Беляева об основе доместикации как бессознатель-ном отборе человеком каменного века неагрессивных животных была подтверждена многолетними уникальными работами Инсти-тута цитологии и генетики по доместикации серебристо-черных лисиц, крыс-пасюков и американских норок. Обзор посвящен роли медиаторов мозга в механизмах доместикации. Полученные в на-ших исследованиях данные свидетельствуют об участии серото-ниновой системы мозга в перестройке поведения при селекции животных на низкую агрессивность. Установлено, что доместика-ция, превращающая агрессивное дикое животное в неагрессив-ное и дружелюбное, сопровождается у животных разных видов (серебристо-черных лисиц, крыс-пасюков и норок) изменением основных молекулярных элементов, определяющих функциональ-ную активность серотониновой системы. Агрессивные и неагрес-сивные животные различаются по уровню с...

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Involvement of the 5-HT1A and 5-HT1B serotonergic receptor subtypes in sexual arousal in male mice

Cited by 46 publications

References 18 publications

Sexual behavior in male rodents

Sexual behavior in male rodents

A dual physiological character for sexual function: the role of serotonergic receptors

The domestication and the brain: forty years after

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