Involvement of the 5-HT1A receptor in the anti-immobility effects of fluvoxamine in the forced swimming test and mouse strain differences in 5-HT1A receptor binding
“…Mirtazapine inhibits the hetero α 2 receptor on serotonergic neurons to facilitate 5‐HT release [23]. We found that the selective serotonin reuptake inhibitors fluvoxamine or paroxetine elicit antidepressant‐like effects in mice and that these effects are mediated by 5‐HT 1A receptors [24,25]. It has been reported that mirtazapine stimulates 5‐HT 1A receptors, which contributes to its antidepressant effects [23].…”
These data suggest that liensinine and isoliensinine from Nelumbo nucifera Gaertner have antidepressant-like effects and that antidepressant-like effects of liensinine and its analogues are closely related to serotonergic mechanisms.
“…Mirtazapine inhibits the hetero α 2 receptor on serotonergic neurons to facilitate 5‐HT release [23]. We found that the selective serotonin reuptake inhibitors fluvoxamine or paroxetine elicit antidepressant‐like effects in mice and that these effects are mediated by 5‐HT 1A receptors [24,25]. It has been reported that mirtazapine stimulates 5‐HT 1A receptors, which contributes to its antidepressant effects [23].…”
These data suggest that liensinine and isoliensinine from Nelumbo nucifera Gaertner have antidepressant-like effects and that antidepressant-like effects of liensinine and its analogues are closely related to serotonergic mechanisms.
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