2014
DOI: 10.3390/ph7111008
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Involvement of the Antioxidant Effect and Anti-inflammatory Response in Butyrate-Inhibited Vascular Smooth Muscle Cell Proliferation

Abstract: Epigenetic mechanisms by altering the expression and, in turn, functions of target genes have potential to modify cellular processes that are characteristics of atherosclerosis, including inflammation, proliferation, migration and apoptosis/cell death. Butyrate, a natural epigenetic modifier and a histone deacetylase inhibitor (HDACi), is an inhibitor of vascular smooth muscle cell (VSMC) proliferation, a critical event in atherogenesis. Here, we examined whether glutathione peroxidases (GPxs), a family of ant… Show more

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Cited by 37 publications
(38 citation statements)
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“…Indeed, upregulation of total GPx4 in vascular smooth muscle cells by butyrate causes a time‐dependent increase in the nuclear localization of this protein and almost complete disappearance from the cytoplasm (Mathew et al . ). Moreover, overexpression of c‐GPx4 in Gpx4 ‐null mice leads to an accumulation of this protein in mitochondria despite the absence of the mitochondrial signal peptide (Liang et al .…”
Section: Resultsmentioning
confidence: 97%
“…Indeed, upregulation of total GPx4 in vascular smooth muscle cells by butyrate causes a time‐dependent increase in the nuclear localization of this protein and almost complete disappearance from the cytoplasm (Mathew et al . ). Moreover, overexpression of c‐GPx4 in Gpx4 ‐null mice leads to an accumulation of this protein in mitochondria despite the absence of the mitochondrial signal peptide (Liang et al .…”
Section: Resultsmentioning
confidence: 97%
“…HDAC inhibitors block this action and thereby affect gene expression. HDIs modulate the histone modification pattern and generate a novel genomic expression profile in VSMCs . To further confirm the induction of eNOS by HDIs and explore its mechanism, we examined the acetylation of histones H3 and H4 on the eNOS promoter region under Bur treatment.…”
Section: Resultsmentioning
confidence: 99%
“…HDIs are a group of proteins that regulate histone acetylation in nucleosomes and mediate changes in chromatin conformation, leading to the regulation of gene expression . Accumulating evidence shows that HDIs modulate histone acetylation states for the transcriptional control of proliferative genes such as p21 and p27 . However, the epigenetic mechanism involved in the HDI‐mediated suppression of VSMC proliferation is not completely understood.…”
Section: Introductionmentioning
confidence: 99%
“…A. muciniphila, likely played a greater role for the observed effects on host lipid metabolism. Furthermore, E. dolichum is a butyrate‐producing bacterium and butyrate has anti‐inflammatory properties and can reduce proliferation of vascular smooth muscle cells in vitro .…”
Section: Discussionmentioning
confidence: 99%