Involvement of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and invasion of human multiple myeloma cells

Shao, Jing; Wang, Hongxiang; Yuan, Guolin; Chen, Zhichao; Li, Qiubai

doi:10.7717/peerj.1925

Cited by 8 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the epoxygenase cytochrome P450 pathway plays a central role in various cellular functions. At the same time, cell division and regulation of complement activation plays an onocogenic role during tumor initiation and progression[18].…”

Section: Disscusionmentioning

confidence: 99%

Identification of differentially expressed genes in hepatocellular carcinoma by integrated bioinformatic analysis

Yan

2019

Preprint

View full text Add to dashboard Cite

31Hepatocellular carcinoma is one of the most common tumors in the world 32 and has a high mortality rate. This study elucidates the mechanism of hepatocellular 33 carcinoma-(HCC) related development. The HCC gene expression profile 34 (GSE54238, GSE84004) was downloaded from Gene Expression Omnibus for 35 comprehensive analysis. A total of 359 genes were identified, of which 195 were 36 upregulated and 164 were downregulated. Analysis of the condensed results showed 37 that "extracellular allotrope" is a substantially enriched term. "Cell cycle", "metabolic 38 pathway" and "DNA replication" are three significantly enriched Kyoto Encyclopedia 39 of Genes and Genomespathways. Subsequently, a protein-protein interaction network 40 was constructed. The most important module in the protein-protein interaction 41 network was selected for path enrichment analysis. The results showed that CCNA2, 42 PLK1, CDC20, UBE2C and AURKA were identified as central genes, and the 43 expression of these five hub genes in liver cancer was significantly increased in The 44 Cancer Genome Atlas. Univariate regression analysis was also performed to show that 45 the overall survival and disease-free survival of patients in the high expression group 46 were longer than in the expression group. In addition, genes in important modules are 47 mainly involved in "cell cycle", "DNA replication" and "oocyte meiosis" signaling 48 pathways. Finally, through upstream miRNA analysis, mir-300 and mir-381-3p were 49 found to coregulate CCNA2,AURKA and UBE2C. These results provide a set of 50 targets that can help researchers to further elucidate the underlying mechanism of 51 liver cancer. 3 52 53 Key Words HCC;GEO;TCGA;DEGs;bioinformatic analysis; 54 55 1. Introduction 56 Liver cancer is one of the most common cancers in the world, and mainly 57 includes three different pathological types comprising hepatocellular carcinoma 58 (HCC), intrahepatic bile duct (ICC) and HCC-ICC hybrid types, among which HCC 59accounts for 85% to 90% of all HCCs.The incidence and mortality of HCC increase 60 with age, and the incidence of HCC is about three times higher in men than in 61 women[1]. Although HCC treatment has made great progress in recent years, the 62 5-year survival rate of HCC patients is still <25%[2]. Therefore, more research are 63 needed to understand the molecular mechanisms of HCC development and 64 progression, which is important to develop more effective diagnostics and treatments. 65 66 At present, gene microarray technology has been widely used to collect 67 gene chip expression profiling data and to study gene expression profiles in many 68 human cancers. A large amount of data has been published in public database 69 platforms, and researchers have integrated these databases to find valuable 70 information about cancer pathogenesis. Lau et al. identified approximately 4,000 71 genes in 10 pairs of HCC and non-tumor tissues by microarray technology[3].Zhou et 72 al. analyzed the mRNA expression profiles of a large number of human HCC 73 spe...

show abstract

Section: Disscusionmentioning

confidence: 99%

Identification of differentially expressed genes in hepatocellular carcinoma by integrated bioinformatic analysis

Yan

2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Cytochrome P450 3A4 (CYP3A4) expression promotes STAT3-mediated breast cancer cell growth via 14,15-EET [259]. EET analogs and sEH inhibitors are thought to have application in multiple diseases [260], such as Parkinson's [261], renal interstitial fibrosis in obstructive nephropathy [258], marrow or cord blood transplantation [262], inflammatory bowel disease-associated cancer [263], and other cancers [264,265].…”

Section: Epoxyeicosatrienoic Acids (Eets)mentioning

confidence: 99%

Eicosanoids in carcinogenesis

Brücher

Jamall

2019

4open

View full text Add to dashboard Cite

Inflammation is the body's reaction to pathogenic (biological or chemical) stimuli and covers a burgeoning list of compounds and pathways that act in concert to maintain the health of the organism. Eicosanoids and related fatty acid derivatives can be formed from arachidonic acid and other polyenoic fatty acids via the cyclooxygenase and lipoxygenase pathways generating a variety of pro- and anti-inflammatory mediators, such as prostaglandins, leukotrienes, lipoxins, resolvins and others. The cytochrome P450 pathway leads to the formation of hydroxy fatty acids, such as 20-hydroxyeicosatetraenoic acid, and epoxy eicosanoids. Free radical reactions induced by reactive oxygen and/or nitrogen free radical species lead to oxygenated lipids such as isoprostanes or isolevuglandins which also exhibit pro-inflammatory activities. Eicosanoids and their metabolites play fundamental endocrine, autocrine and paracrine roles in both physiological and pathological signaling in various diseases. These molecules induce various unsaturated fatty acid dependent signaling pathways that influence crosstalk, alter cell–cell interactions, and result in a wide spectrum of cellular dysfunctions including those of the tissue microenvironment. Although the complete role of eicosanoids, including that of the recently elucidated anti-inflammatory specialized pro-resolving lipid mediators (SPMs), e.g. lipoxins, resolvins, protectins and maresins, is not completely understood, the result of unremitting chronic inflammation is fostering early stages of carcinogenesis. Chronic inflammation facilitates the transition from a normal cell to a cancerous one. The disruption of homeostasis across a wide, but identifiable, swath of diverse molecular pathways creates a micromilieu which constitutes an early and necessary step in the 6-step sequence of carcinogenesis for the vast majority of cancers, termed “sporadic cancers”.

show abstract

“…3 Epoxyeicosatrienoic acids (EETs) have multiple biological activities in the cardiovascular and renal systems. 4 Renal EETs have anti-inflammatory, anti-apoptotic, proangiogenic, fibrinolytic and anti-hypertensive roles. 5 Therefore, EETs are often termed renoprotective agents.…”

Section: Introductionmentioning

confidence: 99%

<p>The Human Genetic Variants CYP2J2 rs2280275 and EPHX2 rs751141 and Risk of Diabetic Nephropathy in Egyptian Type 2 Diabetic Patients</p>

Habieb

Dawood

Emara

et al. 2020

TACG

View full text Add to dashboard Cite

Involvement of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and invasion of human multiple myeloma cells

Cited by 8 publications

References 34 publications

Identification of differentially expressed genes in hepatocellular carcinoma by integrated bioinformatic analysis

Identification of differentially expressed genes in hepatocellular carcinoma by integrated bioinformatic analysis

Eicosanoids in carcinogenesis

<p>The Human Genetic Variants CYP2J2 rs2280275 and EPHX2 rs751141 and Risk of Diabetic Nephropathy in Egyptian Type 2 Diabetic Patients</p>

Contact Info

Product

Resources

About