Involvement of the basolateral complex and central nucleus of amygdala in the omission effects of different magnitudes of reinforcement

Judice-Daher, Danielle Marcilio; Tavares, Tatiane Ferreira; Bueno, José Lino Oliveira

doi:10.1016/j.bbr.2012.04.046

Cited by 16 publications

(30 citation statements)

References 41 publications

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“…These data accompany the results of studies that have investigated the involvement of amygdala substructures on the ROEs suggesting that the amygdala, in particular the BLA and the CeA, may be part of a more complex brain circuitry involved in the ROEs (Bueno et al, 2013;Judice-Daher et al, 2012).…”

Section: Discussionsupporting

confidence: 61%

“…The results of this study showed that (1) the large neurotoxic lesions of the amygdala (involving both the BLA and the CeA) eliminated the ROEs; (2) bilateral lesions of the BLA seem to make the rats more sensitive to reinforcement omission; the response rates of rat groups with lesion of BLA were higher after the reinforcement omission than those observed in the sham-operated group; and (3) the bilateral lesions of CeA did not interfere with the ROEs. According to Judice-Daher et al (2012), the larger lesion of the amygdala, involving both the CeA and the BLA, eliminated the ROEs, because it may have affected a larger number of connections between the amygdala and other structures that may also be involved in the modulation of ROEs. These connections may have been preserved when the BLA and CeA were damaged in isolation.…”

Section: Introductionmentioning

confidence: 99%

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O efeito da omissão de reforço no repertório de ratos com lesão no complexo basolateral e no núcleo central da amígdala

Bueno

Bernardes

Judice-Daher

2012

reveto

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Reinforcement omission has been used as a procedure for the evaluation of attentional and motivational processes. Studies show that the activation of some amygdala nuclei may be involved in the modulation of these processes. This study examined the reinforcement omission effects on behavioral repertoire of rats with lesions in the central nucleus and basolateral complex of the amygdala, using classical conditioning and non-contingent reinforcement schemes. Each trial constituted of a 20 second tone, always followed by the delivery of water, in the 19 th second. In the sessions involving omission, the water was delivered in half of the trials. The results showed that all groups responded to the omission and only the Basolateral group showed effect in the "Rearing" category, in the period after the omission. These results highlight the need to consider the involvement of a more complex neural network for evaluation of these effects. Keywords: reinforcement omission, behavioral repertoire, central nucleus of the amygdala, basolateral complex of the amygdala. O efeito da omissão de reforço no repertório de ratos com lesão no complexo basolateral e no núcleo central da amígdalaA omissão de reforço tem sido usada como procedimento de avaliação dos processos atencionais e motivacionais. Estudos mostram que a ativação de alguns núcleos da amígdala pode estar envolvida na modulação destes processos. O presente trabalho examinou os efeitos da omissão do reforço no repertório comportamental de ratos com lesões no núcleo central e complexo basolateral da amígdala, utilizando-se de esquemas de condicionamento clássico e reforçamento não-contingente. Cada prática constituía de um sinal sonoro de 20 segundos, sempre seguido da liberação de água, no 19º segundo. Nas sessões que envolviam omissão, a água era liberada em metade das práticas. Os resultados mostraram que todos os grupos responderam à omissão e somente o grupo Basolateral apresentou efeito na categoria "Levantar-se", no período após a omissão. Estes resultados apontam a necessidade de se considerar o envolvimento de uma rede neural mais complexa para avaliação destes efeitos. Palavras-chave: omissão de reforço, repertório comportamental, núcleo central da amígdala, complexo basolateral da amígdala.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

O efeito da omissão de reforço no repertório de ratos com lesão no complexo basolateral e no núcleo central da amígdala

Bueno

Bernardes

Judice-Daher

2012

reveto

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“…Other studies have shown that either NAC or BLA lesions interfere with the ROE Judice-Daher et al, 2012;, and the neural substrates involved in the processes related to the ROE may include subcortical rather than cortical structures.…”

Section: Discussionmentioning

confidence: 96%

Lesions of the orbitofrontal cortex do not affect the reinforcement omission effect in rats.

Judice-Daher

Bueno

2013

Psychology & Neuroscience

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The reinforcement omission effect (ROE), reflected by response rates that are higher after reinforcement omission than after reinforcement delivery, has been attributed to both motivational and attentional consequences of the surprising reinforcement omission. These processes depend on the operation of separate amygdala areas and their connections with other brain systems. The interaction between the amygdala and orbitofrontal cortex has been suggested to be important in the modulation of motivational processes. The present study sought to verify whether the mechanisms involved in the ROE depend on the integrity of the orbitofrontal cortex. Prior to acquisition training, rats received bilateral excitotoxic lesions of the orbitofrontal cortex or sham lesions. Following postoperative recovery, the rats were trained on a fixed-interval 12 s limited-hold 6 s signaled schedule of reinforcement. After the acquisition of stable performance, the training was changed from a 100% to 50% schedule of reinforcement. The results showed that rats in both groups exhibited the ROE, with no differences in performance between groups following nonreinforcement. These data do not support the hypothesis that the orbitofrontal cortex is included in the neural substrates related to ROE modulation. The results also showed no difference in response rates between groups in the periods that preceded and followed nonreinforcement. These findings confirm previous studies that showed that the ROE is not related to the facilitation of behavior induced by nonreinforcement. Keywords: reinforcement omission effect, orbitofrontal cortex, operant behavior, rats.

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“…The amygdala appears to be necessary for processes that involve updating of representations of value, not only in fear extinction, but also in reinforcer devaluation (Morrison and Salzman, 2010). Accordingly, amygdala participation in appetitive extinction has been demonstrated for food-reward extinction learning (Judice-Daher et al, 2012;Portero-Tresserra et al, 2013), for extinction of responding to a visual CS which had been paired with food reward (Lindgren et al, 2003). Recent neuroimaging studies suggest that the human amygdala is involved in many reward-based decision-making tasks (Morrison and Salzman, 2010).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal activation during extinction learning predicts occurrence of the renewal effect in extinction recall

et al. 2013

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Involvement of the basolateral complex and central nucleus of amygdala in the omission effects of different magnitudes of reinforcement

Cited by 16 publications

References 41 publications

O efeito da omissão de reforço no repertório de ratos com lesão no complexo basolateral e no núcleo central da amígdala

O efeito da omissão de reforço no repertório de ratos com lesão no complexo basolateral e no núcleo central da amígdala

Lesions of the orbitofrontal cortex do not affect the reinforcement omission effect in rats.

Hippocampal activation during extinction learning predicts occurrence of the renewal effect in extinction recall

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