Involvement of the CA1 GABAA receptors in ACPA-induced impairment of spatial and non-spatial novelty detection in mice

Yousefi, Behnam; Farjad, Meisam; Nasehi, Mohammad; Zarrindast, Mohammad Reza

doi:10.1016/j.nlm.2012.12.001

Cited by 33 publications

(18 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some other studies have reported similar effects of intra-CA1 bicuculline on memory retention (Zarrindast et al, 2002) and the detection of spatial change and nonspatial novelty (Yousefi et al, 2013). Some other studies have reported similar effects of intra-CA1 bicuculline on memory retention (Zarrindast et al, 2002) and the detection of spatial change and nonspatial novelty (Yousefi et al, 2013).…”

Section: Discussionmentioning

confidence: 84%

Involvement of the CA1 GABAA receptors in MK-801-induced anxiolytic-like effects

Naseri

Tackallou

Nami

et al. 2014

Behavioural Pharmacology

Self Cite

View full text Add to dashboard Cite

There seems to be a close relationship between hippocampal N-methyl-D-aspartic acid (NMDA) and GABAA receptors with respect to the modulation of behavior that occurs in the CA1 region of the hippocampus. This study investigated the possible involvement of the CA1 GABAA receptors in anxiolytic-like effects induced by (+)-MK-801 (a noncompetitive antagonist of the NMDA subtype of the glutamate receptor). Male Wistar rats were subjected to the elevated plus-maze apparatus and open arm time (%OAT), and open arm entries (%OAE) for anxiety-related behaviors, and closed arm entries that correspond to the locomotor activity were assessed. An intra-CA1 injection of (+)-MK-801 (2 μg/rat) and muscimol (0.5 μg/rat; a GABAA receptor agonist) increased %OAT and %OAE by themselves while not altering the closed arm entries, indicating an anxiolytic-like effect of these drugs. Injection of bicuculline (0.1, 0.25, and 0.5 μg/rat; a GABAA receptor antagonist) did not alter any of the anxiety-related parameters. An intra-CA1 injection of a subthreshold dose of muscimol (0.1 μg/rat) or bicuculline (0.5 μg/rat), 5 min before injection of subthreshold and effective doses of (+)-MK-801 (0.5, 1 and 2 μg/rat), increased and decreased the anxiolytic-like effect of (+)-MK-801, respectively. The isobologram analysis of these findings suggested a synergistic anxiety-like effect of intra-CA1 (+)-MK-801 and muscimol. In conclusion, the CA1 GABAA receptors appear to be involved in anxiolytic-like behaviors induced by (+)-MK-801.

show abstract

Section: Discussionmentioning

confidence: 84%

Involvement of the CA1 GABAA receptors in MK-801-induced anxiolytic-like effects

Naseri

Tackallou

Nami

et al. 2014

Behavioural Pharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, GABAergic regulation of neuronal architecture has been reported. A hippocampal GABA A receptor agonist has been shown to impair spatial memory [27]. Prior studies in mutant mice have shown that enhanced GABA B receptor activity reduces the expression of immediate-early genes that encode the protein activity-regulated cytoskeleton-associated protein (Arc) which is essential for synaptic plasticity and memory [28, 29].…”

Section: Discussionmentioning

confidence: 99%

Identifying the appropriate time for deep brain stimulation to achieve spatial memory improvement on the Morris water maze

et al. 2017

View full text Add to dashboard Cite

BackgroundThe possibility of using deep brain stimulation (DBS) for memory enhancement has recently been reported, but the precise underlying mechanisms of its effects remain unknown. Our previous study suggested that spatial memory improvement by medial septum (MS)-DBS may be associated with cholinergic regulation and neurogenesis. However, the affected stage of memory could not be distinguished because the stimulation was delivered during the execution of all memory processes. Therefore, this study was performed to determine the stage of memory affected by MS-DBS. Rats were administered 192 IgG-saporin to lesion cholinergic neurons. Stimulation was delivered at different times in different groups of rats: 5 days before the Morris water maze test (pre-stimulation), 5 days during the training phase of the Morris water maze test (training-stimulation), and 2 h before the Morris water maze probe test (probe-stimulation). A fourth group of rats was lesioned but received no stimulation. These four groups were compared with a normal (control) group.ResultsThe most effective memory restoration occurred in the pre-stimulation group. Moreover, the pre-stimulation group exhibited better recall of the platform position than the other stimulation groups. An increase in the level of brain derived neurotrophic factor (BDNF) was observed in the pre-stimulation group; this increase was maintained for 1 week. However, acetylcholinesterase activity in the pre-stimulation group was not significantly different from the lesion group.ConclusionMemory impairment due to cholinergic denervation can be improved by DBS. The improvement is significantly correlated with the up-regulation of BDNF expression and neurogenesis. Based on the results of this study, the use of MS-DBS during the early stage of disease may restore spatial memory impairment.

show abstract

“…The apparatus used for the study was the same as in previous reports [30,31]. It was a metal circular box, 60 cm in diameter with a 20 cm-high wall.…”

Section: Description Of the Experimental Apparatusmentioning

confidence: 99%

Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection

Nasehi

Rostam-Nezhad

Ebrahimi-Ghiri

et al. 2017

Behavioural Brain Research

Self Cite

View full text Add to dashboard Cite

Functional interaction between cannabinoid and serotonin neuronal systems have been reported in different tasks related to memory assessment. The present study investigated the effect of serotonin 5-HT4 agents into the dorsal hippocampus (the CA1 region) on spatial and object novelty detection deficits induced by activation of cannabinoid CB1 receptors (CB1Rs) using arachidonylcyclopropylamide (ACPA) in a non-associative behavioral task designed to forecast the ability of rodents to encode spatial and non-spatial relationships between distinct stimuli. Post-training, intra-CA1 microinjection of 5-HT4 receptor agonist RS67333 or 5-HT4 receptor antagonist RS23597 both at the dose of 0.016μg/mouse impaired spatial memory, while cannabinoid CB1R antagonist AM251 (0.1μg/mouse) facilitated object novelty memory. Also, post-training, intraperitoneal administration of CB1R agonist ACPA (0.005-0.05mg/kg) impaired both memories. However, a subthreshold dose of RS67333 restored ACPA response on both memories. Moreover, a subthreshold dose of RS23597 potentiated ACPA (0.01mg/kg) and reversed ACPA (0.05mg/kg) responses on spatial memory, while it potentiated ACPA response at the dose of 0.005 or 0.05mg/kg on object novelty memory. Furthermore, effective dose of AM251 restored ACPA response at the higher dose. AM251 blocked response induced by combination of RS67333 or RS23597 and the higher dose of ACPA on both memories. Our results highlight that hippocampal 5-HT4 receptors differently affect cannabinoid signaling in spatial and object novelty memories. The inactivation of CB1 receptors blocks the effect of 5-HT4 agents into the CA1 region on memory deficits induced by activation of CB1Rs via ACPA.

show abstract

Involvement of the CA1 GABAA receptors in ACPA-induced impairment of spatial and non-spatial novelty detection in mice

Cited by 33 publications

References 110 publications

Involvement of the CA1 GABAA receptors in MK-801-induced anxiolytic-like effects

Involvement of the CA1 GABAA receptors in MK-801-induced anxiolytic-like effects

Identifying the appropriate time for deep brain stimulation to achieve spatial memory improvement on the Morris water maze

Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection

Contact Info

Product

Resources

About