Involvement of the catecholaminergic system on the antidepressant-like effects of<i>Alpinia zerumbet</i>in mice

Bevilaqua, Fernanda; Mocelin, Ricieri; Grimm, Celso; Silva, Nairo Stefanello da; Buzetto, Thales Luis Brust; Conterato, Greicy M. M.; Junior, Walter Antônio Roman; Piato, Ângelo

doi:10.3109/13880209.2015.1025287

Cited by 9 publications

(8 citation statements)

References 24 publications

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“…AMPT pretreatment (100 mg/kg) has been reported to reduce norepinephrine and dopamine levels by 53% and 57%, respectively, in the brains of mice without affecting serotonin levels (Mayorga et al, 2001; Widerlöv and Lewander, 1978). In this study, AMPT pretreatments did not alter the immobility time of control animals in parallel with the results of the previous studies (Bevilaqua et al, 2016; Can et al, 2013, 2017; Kwon et al, 2010; Pałucha-Poniewiera et al, 2017). However, it abolished the anti-immobility effect of tofisopam in the TST (Figure 3(b)), indicating that the catecholaminergic system, together with the serotonergic system, mediates the antidepressant-like effect of the drug.…”

Section: Discussionsupporting

confidence: 91%

Antidepressant-like effect of tofisopam in mice: A behavioural, molecular docking and MD simulation study

et al. 2022

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Background: Depression is a disease that affects millions of people worldwide, and the discovery and development of effective and safe antidepressant drugs is one of the important topics of psychopharmacology. Objectives: In this study, it was aimed to investigate the antidepressant-like activity potential of tofisopam, an anxiolytic drug with 2,3-benzodiazepine structure, and to elucidate the pharmacological mechanisms mediating this effect. Methods: The antidepressant-like activity of tofisopam was investigated using tail suspension and modified forced swimming tests. Possible interactions of tofisopam with µ- and δ-opioid receptor subtypes were clarified by pharmacological antagonism, molecular docking and molecular dynamics simulation studies. Results: Tofisopam (50 and 100 mg/kg) significantly shortened the immobility time of mice in both the tail suspension and the modified forced swimming tests. The drug, at the same doses, prolonged the duration of swimming and climbing behaviours measured in modified forced swimming tests. A dosage of 25 mg/kg was ineffective. Mechanistic studies showed that the pretreatment with p-chlorophenylalanine methyl ester (serotonin synthesis inhibitor; 4 consecutive days, 100 mg/kg), α-methyl-para-tyrosine methyl ester (catecholamine synthesis inhibitor; 100 mg/kg), naloxonazine (selective µ-opioid receptor blocker, 7 mg/kg) and naltrindole (a selective δ-opioid receptor blocker, 0.99 mg/kg) abolished the anti-immobility effect induced by the 50 mg/kg dose of tofisopam in the tail suspension tests. Our in silico studies supported the behavioural findings that the antidepressant-like effect of tofisopam is mediated by μ- and δ-opioid receptors. Conclusion: This study is the first to show that tofisopam has antidepressant-like activity mediated by the serotonergic, catecholaminergic and opioidergic systems.

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Section: Discussionsupporting

confidence: 91%

Antidepressant-like effect of tofisopam in mice: A behavioural, molecular docking and MD simulation study

et al. 2022

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“…All behavioural tests were videotaped and quantified by an animal movement analysis system (SMART, Panlab SL, Barcelona, Spain). The behavioural tests used are well established 2 , 4 , 14 , 52 – 54 . The experimental timeline and study design are shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine

Bai

Zhang

Chen

et al. 2017

Sci Rep

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Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined the effects of DG and venlafaxine (VLX) in a chronic social defeat stress model of depression. Both DG and VLX attenuated stress-induced social deficits, despair behaviour and exploratory behaviour. To elucidate the metabolic changes underlying the antidepressive effects of DG and VLX, we investigated candidate functional pathways in the prefrontal cortex using a GC-MS-based metabolomics approach. Metabolic functions and pathways analysis revealed that DG and VLX affect protein biosynthesis and nucleotide metabolism to enhance cell proliferation, with DG having a weaker impact than VLX. Glutamate and aspartate metabolism played important roles in the antidepressant effects of DG and VLX. Tyrosine degradation and cell-to-cell signaling and interaction helped discriminate the two antidepressants. L-glutamic acid was negatively correlated, while hypoxanthine was positively correlated, with the social interaction ratio. Understanding the metabolic changes produced by DG and VLX should provide insight into the mechanisms of action of these drugs and aid in the development of novel therapies for depression.

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“…Segundo Xuan e Teschke (2015), 5,6-Dehidrokawain (DK) e dihidro-5,6dehidrokawain (DDK) (Figura 1) são os principais constituintes de AZ sendo os responsáveis pelas propriedades terapêuticas da espécie (XUAN e TESCHKE, 2015). No entanto, existem outros compostos como Kaempferol-3-O-β-D-glucuronide (KOG), labdadieno, 2,5-bis(1E, 3E, 5E)-6-metoxihexa-1,3,5-trien-1-il)-2,5-di-hidrofurano (MTD), (E)-2,2,3,3-tetrametil-8-metileno-7-(oct-6en-1-il) octa-hidro-1H-quinolizina(TMOQ), pinostrobina (PTB), (E)-5-metoxi-8-(4-metoxi-2-oxo-2Hpiran-6-il)-7-fenil-1-estiril-2oxabiciclo[4.2.0]oct-4-en-3-1 (AS-2), tepinen-4-ol, 1,8-cineol e γ-cadinol, hispidina (H) e seus derivados (H1-H3) que também foram avaliados como possíveis compostos ativos para as atividades da AZ na última década (Figura 1) (NGUYEN et al, 2014;MENDES et al, 2015; TAIRA; NGUYEN e TAWATA, 2017; ROMAN JUNIOR et al, 2017;SHAHINOZZAMAN et al, 2018 (BEVILAQUA et al, 2016). Mas apesar dos avanços quanto a ação dos derivados da AZ, é importante destacar a necessidade de mais estudos para confirmar quais os possíveis transportadores e receptores envolvidos no seu efeito antidepressivo e ansiolítico e elucidar seus respectivos mecanismos de ação.…”

Section: Caracterização Fitoquímicaunclassified

“…Segundo Correa, Lima e Costa (2010) estudos publicados até 2008 avaliaram e, na maioria dos casos, comprovaram a atividade antimicrobiana, anticâncer, antioxidante, anti-hipertensiva, diurética e antinociceptiva de óleos essenciais, extratos e compostos isolados extraídos de partes dessa planta (CORREA; LIMA; COSTA, 2010). Contudo, a evolução da ciência na última década se deu de forma exponencial, promovendo o aperfeiçoamento de métodos de extração e isolamento, auxiliando assim, no desenvolvimento de estudos relacionados às vias de sinalização envolvidas nas atividades biológicas já conhecidas da AZ e na descoberta de novas, tais como atividade ansiolítica e antidepressiva (BEVILAQUA et al, 2016;ROMAN JUNIOR et al, 2017;SATOU et al, 2010). Assim, nesta revisão encontram-se pesquisas publicadas na última década (2010-2020) trazendo atualizações sobre os principais estudos quanto as atividades biológicas da AZ com discussão dos potenciais terapêuticos dessa espécie tão comum na região Nordeste.…”

Section: Introductionunclassified

Aplicações Terapêuticas Da Alpinia Zerumbet (Colônia) Baseado Na Medicina Tradicional: Uma Revisão Narrativa (2010-2020) / Therapeutic Applications of the Alpinia Zerumbet (Colônia) Based on Traditional Medicine: A Narrative Review (2010-2020)

Azevedo

Lins

2020

BJD

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RESUMO Alpinia zerumbet L. é uma planta medicinal utilizada na maioria dos estados do nordeste brasileiro. Ela vem sendo objeto de estudo a muitos anos devido ao seu vasto potencial terapêutico, avançando bastante na última década, quando teve aspectos aprofundados das suas já conhecidas atividades biológicas, como antineoplásica, antimicrobiana e anti-inflamatória, e indicação de novas, como ansiolítica e antidepressiva. Os resultados expostos nessa revisão reforçam que A. zerumbet é uma fonte rica em compostos bioativos passíveis de utilização para atividades variadas.

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Involvement of the catecholaminergic system on the antidepressant-like effects ofAlpinia zerumbetin mice

Cited by 9 publications

References 24 publications

Antidepressant-like effect of tofisopam in mice: A behavioural, molecular docking and MD simulation study

Antidepressant-like effect of tofisopam in mice: A behavioural, molecular docking and MD simulation study

Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine

Aplicações Terapêuticas Da Alpinia Zerumbet (Colônia) Baseado Na Medicina Tradicional: Uma Revisão Narrativa (2010-2020) / Therapeutic Applications of the Alpinia Zerumbet (Colônia) Based on Traditional Medicine: A Narrative Review (2010-2020)

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