Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD

Verger, Antoine; Rousseau, Pierre-François; Malbos, Éric; Chawki, Mohammad B.; Nicolas, Florian; Lançon, Christophe; Khalfa, S.; Guedj, Éric

doi:10.1080/20008198.2020.1767986

Cited by 8 publications

(4 citation statements)

References 43 publications

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“…Alterations in the SN were also reported, with another study considering the cerebellar lobules V-VI together with the posterior insula and the precuneus as part of the posterior Salience Network (SN) and reporting that individuals with PTSD showed increased connectivity between the latter and the posterior insula, the cuneus and precuneus, while they exhibited decreased connectivity between the posterior SN and the dlPFC and the supramarginal gyrus ( Nicholson et al, 2020 ). This is in line with a recent study which showed that decreased connectivity between cerebellar lobule VI and Crus I with the precuneus was associated with a decrease in clinical symptoms in a PTSD sample, after a trauma-focused intervention ( Verger et al, 2020 ) and another study that showed that ALFF in the precuneus and the cerebellar Crus I, among other regions, predicted whether PTSD patients would be responsive to paroxetine treatment ( Yuan et al, 2018 ) Also, decreased FC was reported between the cerebellum and the dorsal anterior cingulate cortex (dACC), another major player of the SN( Seeley et al, 2007 ), in trauma-exposed individuals with and without PTSD versus healthy controls ( Chen et al, 2019 ).…”

Section: Discussionsupporting

confidence: 93%

The cerebellum and psychological trauma: A systematic review of neuroimaging studies

Blithikioti

Nuño

Guell

et al. 2022

Neurobiology of Stress

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Psychological trauma is highly prevalent among psychiatric disorders, however, the relationship between trauma, neurobiology and psychopathology is not yet fully understood. The cerebellum has been recognized as a crucial structure for cognition and emotion, however, it has been relatively ignored in the literature of psychological trauma, as it is not considered as part of the traditional fear neuro-circuitry. The aim of this review is to investigate how psychological trauma affects the cerebellum and to make conclusive remarks on whether the cerebellum forms part of the trauma-affected brain circuitry. A total of 267 unique records were screened and 39 studies were included in the review. Structural cerebellar alterations and aberrant cerebellar activity and connectivity in trauma-exposed individuals were consistently reported across studies. Early-onset of adverse experiences was associated with cerebellar alterations in trauma-exposed individuals. Several studies reported alterations in connectivity between the cerebellum and nodes of large-brain networks, which are implicated in several psychiatric disorders, including the default mode network, the salience network and the central executive network. Also, trauma-exposed individuals showed altered resting state and task based cerebellar connectivity with cortical and subcortical structures that are involved in emotion and fear regulation. Our preferred interpretation of the results is through the lens of the Universal Cerebellar Transform, the hypothesis that the cerebellum, given its homogeneous cytoarchitecture, performs a common computation for motor, cognitive and emotional functions. Therefore, trauma-induced alterations in this computation might set the ground for a variety of psychiatric symptoms.

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Section: Discussionsupporting

confidence: 93%

The cerebellum and psychological trauma: A systematic review of neuroimaging studies

Blithikioti

Nuño

Guell

et al. 2022

Neurobiology of Stress

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“…Previous functional connectivity studies have confirmed that there are strong links between the posterior cerebellum and the temporal lobes, suggesting these regions share neural similarities and are involved in sensory integration and emotional processing (Yeo et al, 2011;Chan et al, 2019;Heleven et al, 2019;Van Overwalle et al, 2020b). In addition, several positron emission tomography (PET) studies suggest that the posterior cerebellum is involved in various emotional responses, such as fear, sadness, and happiness (Schwartz and Davidson, 1997;Turner et al, 2007;Verger et al, 2020) S2, S3, and Table 2). These results indicate that DFNs are reproducible during repeated movie viewing, further demonstrating that the naturalistic paradigm provides reliable experimental conditions for measuring DFNs.…”

Section: Discussionmentioning

confidence: 94%

Mapping the time-varying functional brain networks in response to naturalistic movie stimuli

et al. 2023

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One of human brain’s remarkable traits lies in its capacity to dynamically coordinate the activities of multiple brain regions or networks, adapting to an externally changing environment. Studying the dynamic functional brain networks (DFNs) and their role in perception, assessment, and action can significantly advance our comprehension of how the brain responds to patterns of sensory input. Movies provide a valuable tool for studying DFNs, as they offer a naturalistic paradigm that can evoke complex cognitive and emotional experiences through rich multimodal and dynamic stimuli. However, most previous research on DFNs have predominantly concentrated on the resting-state paradigm, investigating the topological structure of temporal dynamic brain networks generated via chosen templates. The dynamic spatial configurations of the functional networks elicited by naturalistic stimuli demand further exploration. In this study, we employed an unsupervised dictionary learning and sparse coding method combing with a sliding window strategy to map and quantify the dynamic spatial patterns of functional brain networks (FBNs) present in naturalistic functional magnetic resonance imaging (NfMRI) data, and further evaluated whether the temporal dynamics of distinct FBNs are aligned to the sensory, cognitive, and affective processes involved in the subjective perception of the movie. The results revealed that movie viewing can evoke complex FBNs, and these FBNs were time-varying with the movie storylines and were correlated with the movie annotations and the subjective ratings of viewing experience. The reliability of DFNs was also validated by assessing the Intra-class coefficient (ICC) among two scanning sessions under the same naturalistic paradigm with a three-month interval. Our findings offer novel insight into comprehending the dynamic properties of FBNs in response to naturalistic stimuli, which could potentially deepen our understanding of the neural mechanisms underlying the brain’s dynamic changes during the processing of visual and auditory stimuli.

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“…In addition to autonomic measures, a number of articles cite positron emission tomography data on improvement of cerebellar and precuneus metabolism (following therapy) [ 32 , 33 ], as well as of cardiovascular function [ 59 ].…”

Section: Psychophysiological Methods Of Vret Effectiveness Assessmentmentioning

confidence: 99%

“…Verger [ 32 ] conducted a study where therapy based on eye movement desensitization and reprocessing (EMDR) was combined with stress exposure to VR war scenes and reported a positive sign evidenced by improvement in precuneus metabolism (according to positron emission tomography) in servicemen with PTSD. After EMDR, connectivity reduction of metabolic changes between the precuneus and large bilateral clusters of cerebellum posterior areas (cerebellar lobules Crus I and VI) was observed concurrently with reduction of PTSD clinical manifestations severity.…”

Section: Mechanisms Of Vret Therapeutic Effectmentioning

confidence: 99%

Use of Virtual Reality Techniques to Rehabilitate Military Veterans with Post-Traumatic Stress Disorder (Review)

Volovik¹,

Belova²,

Kuznetsov³

et al. 2023

Sovrem Tehnol Med

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Post-traumatic stress disorder (PTSD) is a mental and behavioral disorder developing after a traumatic event like participation in combat activities. Objective diagnosis of combat PTSD and effective rehabilitation of war veterans is a current multifaceted problem with particularly high social costs. This review aims to evaluate the potential of virtual reality technique used as exposure therapy tool (VRET) to rehabilitate combat veterans and service members with PTSD.The review was written following the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The final analysis includes 75 articles published in 2017-2022.VRET therapeutic effect mechanisms were examined along with protocols and scenarios of VRET combined with other interventions influencing PTSD treatment like pharmacotherapy, motion-assisted multi-modular memory desensitization and reconsolidation (3MDR), transcranial magnetic stimulation. The necessity is substantiated of psychophysiological measurements for objectification of PTSD clinical criteria and its dynamics during treatment. It was shown that inclusion of VRET to the package of PTSD rehabilitation interventions positively affects the results due to the enhanced effect of presence and greater experience personalization. Thus, VRET may be an effective, controlled, and cost-effective alternative for PTSD treatment in combatants, including those not responding to conventional therapy.

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Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD

Cited by 8 publications

References 43 publications

The cerebellum and psychological trauma: A systematic review of neuroimaging studies

The cerebellum and psychological trauma: A systematic review of neuroimaging studies

Mapping the time-varying functional brain networks in response to naturalistic movie stimuli

Use of Virtual Reality Techniques to Rehabilitate Military Veterans with Post-Traumatic Stress Disorder (Review)

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