Involvement of the Dorsal Striatum in Cue-Controlled Cocaine Seeking

Vanderschuren, Louk J. M. J.; Ciano, Patricia Di; Everitt, Barry J.

doi:10.1523/jneurosci.0925-05.2005

Cited by 350 publications

(313 citation statements)

References 80 publications

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“…In contrast, cocaine intake (reinforced nose pokes) was increased by the antagonist in both the first and third weeks, suggesting that this effect likely is not associated with the phasic modality of dopamine signaling time-locked to drug taking, and therefore tonic dopamine signaling may be implicated. This notion is consistent with the work of others indicating a role for DLS dopamine in mediating the reinforcing properties of cocaine (21,22). Therefore, rather than contributing to escalated or compulsive responding, the progressive recruitment of DLS phasic dopamine promotes the refinement of behavior toward reinforced actions, as operant responding for the drug becomes more reliably discriminated over the course of weeks in the absence of escalated drug intake.…”

Section: Dopamine Signaling In the Sensorimotor Striatum Emerges Beforesupporting

confidence: 91%

“…Intra-DLS infusion of flupenthixol resulted in an increase in cocaine intake (reinforced nose pokes) at both the early and late time points (P < 0.05 vs. vehicle; Fig. 4D), suggesting that DLS dopamine may contribute to the reinforcing properties of cocaine, as is consistent with previous reports (21,22). Importantly, this effect therefore is not attributable to the CS-associated phasic dopamine signal, which was present at the late time point but not the early time point.…”

Section: Dopamine Receptors In the Dls Are Necessary For Discriminatedsupporting

confidence: 91%

“…It has been suggested that each of the stages in the series of transitions from goal-directed to habitual and eventually to compulsive responding for drug is associated with specific brain systems that are recruited progressively (10). Indeed, the DLS comes to exert more dominant control over drug seeking during the course of drug use (21,30) as drug taking becomes maintained by drug-associated stimuli (10,12,16). Although we have demonstrated that phasic dopamine release does indeed develop at a later stage of drug use in the DLS than in the VMS, the training regimen used typically is not sufficient to produce compulsive responding or the significant escalation of drug intake that emerges following extended or long-access training in drug self-administration (31,32).…”

Section: Dopamine Signaling In the Sensorimotor Striatum Emerges Beforementioning

confidence: 99%

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Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use

Willuhn

Burgeno

Everitt

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

233

210

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Drug addiction is a neuropsychiatric disorder that marks the end stage of a progression beginning with recreational drug taking but culminating in habitual and compulsive drug use. This progression is considered to reflect transitions among multiple neural loci. Dopamine neurotransmission in the ventromedial striatum (VMS) is pivotal in the control of initial drug use, but emerging evidence indicates that once drug use is well established, its control is dominated by the dorsolateral striatum (DLS). In the current work, we conducted longitudinal neurochemical recordings to ascertain the spatiotemporal profile of striatal dopamine release and to investigate how it changes during the period from initial to established drug use. Dopamine release was detected using fast-scan cyclic voltammetry simultaneously in the VMS and DLS of rats bearing indwelling i.v. catheters over the course of 3 wk of cocaine self-administration. We found that phasic dopamine release in DLS emerged progressively during drug taking over the course of weeks, a period during which VMS dopamine signaling declined. This emergent dopamine signaling in the DLS mediated discriminated behavior to obtain drug but did not promote escalated or compulsive drug use. We also demonstrate that this recruitment of dopamine signaling in the DLS is dependent on antecedent activity in VMS circuitry. Thus, the current findings identify a striatal hierarchy that is instantiated during the expression of established responses to obtain cocaine. D rug use often begins as a recreational behavior driven by the rewarding properties of the abused drug. However, addiction is characterized by habitual and compulsive drug use in which other factors, such as withdrawal symptoms, stress, and drug-associated conditioned stimuli (CS), also contribute to the motivation to consume drugs, and drug taking becomes increasingly prioritized over other behaviors (1). A wealth of evidence shows that the mesolimbic dopamine projection from the ventral tegmental area to the ventromedial striatum (VMS) is central to drug reinforcement (2). The ambient concentration of dopamine in the VMS is increased when animals self-administer drugs of abuse, including cocaine (3), and animals maintain this elevated dopamine level by regulating their rate of responding for drug (4). In addition, with repeated pairing of environmental stimuli with the drug, these CS also gain the propensity to elicit changes in dopamine concentration in the VMS (5-8); and even though these phasic neurochemical responses last only a few seconds, they are capable of controlling drug-seeking and -taking behavior (5). Together, these results implicate dopamine release in the VMS as a critical substrate in the control of drug use (2, 3, 9).However, the progression of drug taking beyond recreational use is thought to reflect the engagement of different psychological processes mediated within several neural loci (10, 11), with a particular emphasis on the incorporation of the sensorimotor (dorsolateral) striatum (DLS) in the c...

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Section: Dopamine Signaling In the Sensorimotor Striatum Emerges Beforesupporting

confidence: 91%

Section: Dopamine Receptors In the Dls Are Necessary For Discriminatedsupporting

confidence: 91%

Section: Dopamine Signaling In the Sensorimotor Striatum Emerges Beforementioning

confidence: 99%

See 1 more Smart Citation

Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use

Willuhn

Burgeno

Everitt

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

233

210

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“…Finally, our results suggest that glutamate transmission in the caudateputamen is not involved in context-induced reinstatement. However, this conclusion is tentative because our injections targeted the ventral part of the caudate-putamen; it was recently reported that blockade of AMPA receptors in the dorsal caudate-putamen attenuates discrete cue-controlled cocaine seeking (Vanderschuren et al, 2005), but see Kantak et al (2002) for different results.…”

Section: Discussionmentioning

confidence: 83%

“…We also studied the effect of LY379268 on context-induced reinstatement after injections into the nearby caudate-putamen, a terminal region of the nigrastriatal dopamine system. The caudate-putamen is known to be involved in stimulus-response learning White and McDonald, 2002), and data from two studies indicate that both dopamine and glutamate in this brain area are involved in cue-controlled cocaine seeking (Ito et al, 2002;Vanderschuren et al, 2005). Additionally, we tested the effect of injections of LY379268 into the NAc core or shell on high rates of lever responding for sucrose in order to rule out the possibility that these injections decrease context-induced reinstatement due to their motor impairing effects on lever pressing.…”

Section: Introductionmentioning

confidence: 99%

Activation of Group II Metabotropic Glutamate Receptors in the Nucleus Accumbens Shell Attenuates Context-Induced Relapse to Heroin Seeking

Bossert

Gray

Lü

et al. 2005

Neuropsychopharmacol

216

173

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Using a rat relapse model, we previously reported that re-exposing rats to a drug-associated context, following extinction of operant responding in a different context, reinstates heroin seeking. In an initial pharmacological characterization, we found that the mGluR 2/3 agonist LY379268, which acts centrally to reduce evoked glutamate release, attenuates context-induced reinstatement of heroin seeking when injected systemically or into the ventral tegmental area, the cell body region of the mesolimbic dopamine system. Here, we tested whether injections of LY379268 into the nucleus accumbens (NAc), a terminal region of the mesolimbic dopamine system, would also attenuate context-induced reinstatement of heroin seeking. Rats were trained to self-administer heroin; drug infusions were paired with a discrete tone-light cue. Subsequently, lever pressing was extinguished in the presence of the discrete cue in a context that differed from the drug self-administration context in terms of visual, auditory, tactile, and circadian cues. After extinction of responding, LY379268 was injected to different groups of rats into the NAc core or shell or into the caudate-putamen, a terminal region of the nigrastriatal dopamine system. Injections of LY379268 into the NAc shell (0.3 or 1.0 mg) dose-dependently attenuated context-induced reinstatement of heroin seeking. Injections of 1.0 mg of LY379268 into the NAc core had no effect, while a higher dose (3.0 mg) decreased this reinstatement. Injections of LY379268 (3.0 mg) 1.5 mm dorsal from the NAc core into the caudate-putamen were ineffective. Results suggest an important role of glutamate transmission in the NAc shell in context-induced reinstatement of heroin seeking.

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Are There Biological Commonalities Among Different Psychiatric Disorders?

Etkin

Pittenger

2015

Psychiatry

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Involvement of the Dorsal Striatum in Cue-Controlled Cocaine Seeking

Cited by 350 publications

References 80 publications

Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use

Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use

Activation of Group II Metabotropic Glutamate Receptors in the Nucleus Accumbens Shell Attenuates Context-Induced Relapse to Heroin Seeking

Are There Biological Commonalities Among Different Psychiatric Disorders?

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