Involvement of the endogenous opioid system in the beneficial influence of physical exercise on amphetamine-induced addiction parameters

Rosa, Higor Zuquetto; Segat, Hecson Jesser; Barcelos, Raquel Cristine Silva; Roversi, Katiane; Rossato, Domênika Rubert; Brum, Gerson Fernandes de; Bürger, Marilise Escobar

doi:10.1016/j.pbb.2020.173000

Cited by 4 publications

(7 citation statements)

References 88 publications

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“…Based on this, our ndings show that TS is able to reduce MOR immunoreactivity in AMPH-exposed animals, indicating a possible decreased in impulsivity and vulnerability to AMPH relapse, which was con rmed in our behavioral outcomes. Similar opioid regulation response is shared by physical exercise and it has been seen that it can prevent relapse in rats addicted to amphetamine [14]. This way, we propose that the two treatment methods produce a similar regulation response.…”

Section: Discussionmentioning

confidence: 57%

“…Previous studies from our laboratory have shown CPP paradigm in experimental protocols related to AMPH addiction [14,29,30], besides other addictive substances such as cocaine [16] and morphine [31][32][33]. Thus, following drug extinction, events such as stress or drug re-exposure can reestablish the addiction, what may be experimentally observed by restoring the drug preference in the CPP paradigm [34].…”

Section: Discussionmentioning

confidence: 99%

“…As relapse is a growing concern, our research group has made efforts to search new nonpharmacological adjuvant therapies for drug addiction, especially to prevent relapse. Among them, we can highlight the physical exercise practice [13,14], neonatal tactile stimulation (TS) [15,16], omega-3 supplementation [17] and AMPH-isotherapic administration [18] and others.…”

Section: Introductionmentioning

confidence: 99%

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Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus Accumbens Preventing Amphetamine Relapse.

Rossato

Rosa

et al. 2022

Preprint

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Amphetamine (AMPH) is a psychostimulant drug frequently related to addiction, which is characterized by functional and molecular changes in the brain reward system, favoring relapse development and pharmacotherapies have shown low effectiveness. Considering the beneficial influences of tactile stimulation (TS) in different diseases that affect the central nervous system (CNS), here we evaluated if TS applied in adult rats could prevent or minimize the AMPH-relapse behavior also accessing molecular neuroadaptations in the Nucleus accumbens (NAc). Following AMPH conditioning in the conditioned place preference (CPP) paradigm, male rats were submitted to TS (15-min session, 3 times a day, for 8 days) during the drug abstinence period, which were re-exposed to the drug in the CPP paradigm for additional 3 days for relapse observation and molecular assessment. Our findings showed that besides AMPH relapse; TS prevented the dopamine transporter (DAT), dopamine 1 receptor (D1R), tyrosine hydroxylase (TH), mu opioid receptor (MOR) increase and AMPH-induced delta FosB (ΔFosB). Based on these outcomes, we propose TS as a useful tool to treat psychostimulant addiction, which subsequent to clinical studies; it could be included in detoxification programs together with pharmacotherapies and psychological treatments already conventionally established.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus Accumbens Preventing Amphetamine Relapse.

Rossato

Rosa

et al. 2022

Preprint

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show abstract

“…Previous studies from our laboratory have shown CPP paradigm in experimental protocol s related to AMPH addiction [ 14 , 33 , 34 ], besides other addictive substances such as cocaine [ 16 ] and morphine [ 35 – 37 ]. Thus, following drug extinction, events such as stress or drug re-exposure can reestablish the addiction, what may be experimentally observed by restoring the drug preference in the CPP paradigm [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…As relapse is a growing concern, our research group has made efforts to search new non-pharmacological adjuvant therapies for drug addiction, especially to prevent relapse. Among them, we can highlight the physical exercise practice [ 13 , 14 ], neonatal tactile stimulation (TS) [ 15 , 16 ], omega-3 supplementation [ 17 ], and AMPH-isotherapic administration [ 18 ], and others.…”

Section: Introductionmentioning

confidence: 99%

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus accumbens Preventing Amphetamine Relapse

Rossato

Rosa

et al. 2022

Mol Neurobiol

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Amphetamine (AMPH) is a psychostimulant drug frequently related to addiction, which is characterized by functional and molecular changes in the brain reward system, favoring relapse development, and pharmacotherapies have shown low effectiveness. Considering the beneficial influences of tactile stimulation (TS) in different diseases that affect the central nervous system (CNS), here we evaluated if TS applied in adult rats could prevent or minimize the AMPH-relapse behavior also accessing molecular neuroadaptations in the nucleus accumbens (NAc). Following AMPH conditioning in the conditioned place preference (CPP) paradigm, male rats were submitted to TS (15-min session, 3 times a day, for 8 days) during the drug abstinence period, which were re-exposed to the drug in the CPP paradigm for additional 3 days for relapse observation and molecular assessment. Our findings showed that besides AMPH relapse, TS prevented the dopamine transporter (DAT), dopamine 1 receptor (D1R), tyrosine hydroxylase (TH), mu opioid receptor (MOR) increase, and AMPH-induced delta FosB (ΔFosB). Based on these outcomes, we propose TS as a useful tool to treat psychostimulant addiction, which is subsequent to clinical studies; it could be included in detoxification programs together with pharmacotherapies and psychological treatments already conventionally established.

show abstract

Physical Exercise Promotes Beneficial Changes on Neurotrophic Factors in Mesolimbic Brain Areas After AMPH Relapse: Involvement of the Endogenous Opioid System

H.Z.,

H.J.,

R.C.S.

et al. 2023

Neurotox Res

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Involvement of the endogenous opioid system in the beneficial influence of physical exercise on amphetamine-induced addiction parameters

Cited by 4 publications

References 88 publications

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus Accumbens Preventing Amphetamine Relapse.

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus Accumbens Preventing Amphetamine Relapse.

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus accumbens Preventing Amphetamine Relapse

Physical Exercise Promotes Beneficial Changes on Neurotrophic Factors in Mesolimbic Brain Areas After AMPH Relapse: Involvement of the Endogenous Opioid System

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