2014
DOI: 10.1254/jphs.14001sc
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Involvement of the Long-Chain Fatty Acid Receptor GPR40 in Depression-Related Behavior

Abstract: Abstract. The functional role of brain G protein-coupled receptor 40 (GPR40) remains unclear. We investigated GPR40 signaling in depression-related behavior in mice via the forced swim test. A repeated but not a single intracerebroventricular administration of the GPR40 agonist, GW9508, reduced the duration of immobility behavior. Moreover, the levels of hippocampal non-esterified docosahexaenoic acid and arachidonic acid were decreased immediately after the forced swimming. These results suggested that brain … Show more

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Cited by 23 publications
(11 citation statements)
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“…For instance, the repeated administration of GW9508, an FFA1 receptor agonist, was able to diminish the immobility time of mice during a forced swimming test. Additionally, the same study showed that DHA and AA levels were decreased in the hippocampus after the behavioral test, although the FFA1 expression remained unaltered [137]. Corroborating these data, Aizawa et al (2016) demonstrated that FFA1 knockout mice exhibited augmented anhedonia and altered levels of serotonin, dopamine, and noradrenaline in the hippocampus [138].…”
Section: Major Depression Disorder (Mdd)mentioning
confidence: 99%
“…For instance, the repeated administration of GW9508, an FFA1 receptor agonist, was able to diminish the immobility time of mice during a forced swimming test. Additionally, the same study showed that DHA and AA levels were decreased in the hippocampus after the behavioral test, although the FFA1 expression remained unaltered [137]. Corroborating these data, Aizawa et al (2016) demonstrated that FFA1 knockout mice exhibited augmented anhedonia and altered levels of serotonin, dopamine, and noradrenaline in the hippocampus [138].…”
Section: Major Depression Disorder (Mdd)mentioning
confidence: 99%
“…In addition, DHA-induced GPR40 signaling pathway activates β-endorphin release in the hypothalamus of rodents ( Nakamoto et al, 2015 ). Importantly, the chronic activation of GPR40 signaling in the brain reduces depressive-like behavior ( Nishinaka et al, 2014 ). In addition, anxiety-like behavior and sucrose preference, a behavioral sign of anhedonia, are reduced in GPR40 knock-out mice further highlighting the role of GPR40 signaling in the pathophysiology of mood disorders ( Aizawa et al, 2016 ).…”
Section: Relevant Mechanisms For Nutritional ω3 Pufa-induced Mood-relmentioning
confidence: 99%
“…However, more recently, expression of FFA1 receptors has been demonstrated in the brains of rodents (Nakamoto et al ., ; Zamarbide et al ., ), and many studies of the functional role of these receptors in the brain have been carried out. For example, there have been several reports that FFA1 receptor signalling in the CNS may contribute to antidepressant effects (Nishinaka et al ., ) and to the generation of new neurons for learning and memory (Ma et al ., ; Ma et al ., ; Boneva and Yamashima, 2011). Our previous study has demonstrated that the i.c.v.…”
Section: Introductionmentioning
confidence: 99%