Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients

Sierpowska, Joanna; Fernández-Coello, Alejandro; Gómez-Andrés, Alba; Camins, Àngels; Castañer, Sara; Juncadella, Montserrat; Gabarrós, Andreu; Rodrı́guez-Fornells, Antoni

doi:10.1016/j.cortex.2017.10.017

Cited by 56 publications

(39 citation statements)

References 81 publications

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“…For opioids, the right angular gyrus and left middle frontal gyrus stood out as two brain areas with the highest concentration of effects. As both areas are multimodal association areas involved in a range of functions including language, number processing, spatial attention, theory of mind for the angular gyrus (Seghier, 2013) and language, executive control for the left middle frontal gyrus (Sierpowska et al, 2018), this finding agrees with previous reports of nonspecific disruptions of attention, cognitive, and regulatory functions associated with prenatal opioids exposure (Nygaard, Slinning, Moe, & Walhovd, 2016). Exposures to alcohol and marijuana prenatally have been both associated with a range of attention, memory, and executive control problems (Coles, 2011; Fried & Smith, 2001; Goldschmidt, Day, & Richardson, 2000), which is in part consistent with our observed more scattered distribution of effects in their corresponding heat maps.…”

Section: Discussionsupporting

confidence: 90%

Functional dissection of prenatal drug effects on baby brain and behavioral development

Salzwedel

Chen

et al. 2020

Human Brain Mapping

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Prenatal drug exposure (PDE) is known to affect fetal brain development with documented long‐term consequences. Most studies of PDE effects on the brain are based on animal models. In this study, based on a large sample of 133 human neonates and leveraging a novel linear mixed‐effect model designed for intersubject variability analyses, we studied the effects of six prenatally exposed drugs (i.e., nicotine, alcohol, selective serotonin reuptake inhibitor, marijuana, cocaine, and opioids) on neonatal whole‐brain functional organization and compared them with five other critical nondrug variables (i.e., gestational age at birth/scan, sex, birth weight, and maternal depression). The behavioral implications were also examined. Magnitude‐wise, through summing across individual drug effects, our results highlighted ~5% of whole‐brain functional connections (FCs) affected by PDE, which was highly comparable with the combined effects of the five nond rug variables. Spatially, the detected PDE effects featured drug‐specific patterns with a common bias in higher‐order brain regions/networks. Regarding brain–behavioral relationships, the detected connections showing significant drug effects also demonstrated significant correlations with 3‐month behavioral outcomes. Further mediation analyses supported a mediation role of the detected brain FCs between PDE status and cognitive/language outcomes. Our findings of widespread, and spatially biased PDE effect patterns coupled with significant behavioral implications may hopefully stimulate more human‐based studies into effects of PDE on long‐term developmental outcomes.

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Section: Discussionsupporting

confidence: 90%

Functional dissection of prenatal drug effects on baby brain and behavioral development

Salzwedel

Chen

et al. 2020

Human Brain Mapping

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“…These pathological behaviors are due to damage of distinct regions within the BLC network, predominantly subcortical (basal ganglia) and/or frontal areas and their connections with striatal structures. The role of these areas in language switching has been also demonstrated by intraoperative electrical stimulation of the MFG and left caudate …”

Section: Overlap Between Ec and Blc Networkmentioning

confidence: 92%

Neural basis of bilingual language control

Calabria

Costa

Green

et al. 2018

Annals of the New York Academy of Sciences

130

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Acquiring and speaking a second language increases demand on the processes of language control for bilingual as compared to monolingual speakers. Language control for bilingual speakers involves the ability to keep the two languages separated to avoid interference and to select one language or the other in a given conversational context. This ability is what we refer with the term "bilingual language control" (BLC). It is now well established that the architecture of this complex system of language control encompasses brain networks involving cortical and subcortical structures, each responsible for different cognitive processes such as goal maintenance, conflict monitoring, interference suppression, and selective response inhibition. Furthermore, advances have been made in determining the overlap between the BLC and the nonlinguistic executive control networks, under the hypothesis that the BLC processes are just an instantiation of a more domain-general control system. Here, we review the current knowledge about the neural basis of these control systems. Results from brain imaging studies of healthy adults and on the performance of bilingual individuals with brain damage are discussed.

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“…Results showed that the three types of words elicited similar activation patterns in brain regions for general cognitive control (i.e., anterior cingulate cortex and bilateral middle frontal gyrus) (Abutalebi & Green, 2007;Seo, Stocco, & Prat, 2018;Sierpowska et al, 2018) and for word reading (i.e., the bilateral inferior frontal gyrus, occipitoparietal cortex, and occipitotemporal cortex) (Bolger et al, 2005;Cattinelli, Borghese, Gallucci, & Paulesu, 2013;Price, 2012) (Figure 2a-c). Results showed that the three types of words elicited similar activation patterns in brain regions for general cognitive control (i.e., anterior cingulate cortex and bilateral middle frontal gyrus) (Abutalebi & Green, 2007;Seo, Stocco, & Prat, 2018;Sierpowska et al, 2018) and for word reading (i.e., the bilateral inferior frontal gyrus, occipitoparietal cortex, and occipitotemporal cortex) (Bolger et al, 2005;Cattinelli, Borghese, Gallucci, & Paulesu, 2013;Price, 2012) (Figure 2a-c).…”

Section: Neural Activations For Chinese English and Artificial Lamentioning

confidence: 94%

Lexical learning in a new language leads to neural pattern similarity with word reading in native language

Chen

et al. 2018

Human Brain Mapping

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Previous neuroimaging studies have suggested similar neural activations for word reading in native and second languages. However, such similarities were qualitatively determined (i.e., overlapping activation based on traditional univariate activation analysis). In this study, using representational similarity analysis and an artificial language training paradigm, we quantitatively computed cross-language neural pattern similarity to examine the modulatory effect of proficiency in the new language. Twenty-four native Chinese speakers were trained to learn 30 words in a logographic artificial language for 12 days and scanned while performing a semantic decision task after 4-day training and after 12-day training. Results showed that higher proficiency in the new language was associated with higher cross-language pattern similarity in select regions of the reading network.

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Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients

Cited by 56 publications

References 81 publications

Functional dissection of prenatal drug effects on baby brain and behavioral development

Functional dissection of prenatal drug effects on baby brain and behavioral development

Neural basis of bilingual language control

Lexical learning in a new language leads to neural pattern similarity with word reading in native language

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