Involvement of the Opsonic System in Starvation Induced Depression of the Reticuloendothelial System

Saba, Thomas M.; Luzio, N. R. Di

doi:10.3181/00379727-128-33145

Cited by 20 publications

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“…RE depression as a result of depressed circulating opsonic activity parallels the observations on starvation induced RE alteration (15) and colloid induced RE "blockade" (14,20) which have been shown to be due to a depletion of opsonins. Restoration of opsonin activity during the R E recovery phase after surgery may reflect the synthesis and/or release of this factor into the blood from a specific tissue compartment (14).…”

Section: Discussionmentioning

confidence: 82%

“…1, is the halftime ( t J 2 ) for the phagocytic clearance of colloidal carbon at various intervals after surgery. A significant ( p < .OOl) depression in vascular clearance of colloidal carbon was observed a t 15 min postsurgery as indicated (14)(15)(16)(17). by the mean 31% increase in the half-time ( t / 2 ) as compared to control values.…”

mentioning

confidence: 98%

“…Although previous findings have revealed the existence of phagocytic changes after surgery, the factors mediating this response have not been determined. Since phagocytic depression can occur as a result of a depletion of circulating plasma factors called opsonins (14,15), R E depression after surgical stress may reflect a depression of opsonin activity.…”

mentioning

confidence: 99%

“…Colloidal carbon (C 11/43, Gunther-Wagner, Hanover, Germany) was injected intravenously a t a dose of 16 mg/100 g of body weight. The gelatinized 1311 "RE test lipid emulsion" was prepared from glycerol, 1311-triolein (Mallinckrodt Nuclear, St. Louis, Missouri), and lecithin mixed in a ratio of 10: 10: 1 by weight, respectively, as previously described (14,15,19). It was injected intravenously at a dose of 50 mg/100 g of body weight.…”

mentioning

confidence: 99%

“…Both colloidal carbon (18) and gelatinized "RE test lipid emulsion" (14,15) were utilized as the test colloids, since they are selectively removed by the process of phagocytosis. Colloidal carbon (C 11/43, Gunther-Wagner, Hanover, Germany) was injected intravenously a t a dose of 16 mg/100 g of body weight.…”

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confidence: 99%

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Mechanism Mediating Reticuloendothelial System Depression After Surgery

Saba¹

1970

Experimental Biology and Medicine

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Involvement of the reticuloendothelial system (RES) in bacterial infection (1, 2), neoplastic disease (3,4), and immunological activity (5, 6) has been well documented. Such studies have emphasized the host defense role of the RES and the need to comprehend factors that induce changes in RE activity.Recent findings by Donovan (7) in humans, and Saba and Di Luzio (8) in animals have demonstrated that surgical manipulation will depress phagocytosis. Moreover, it has been speculated that the decreased resistance (9-10) and increased incidence of metastasis after surgical stress ( 11-1 5) may be due to depressed phagocytosis (8). Although previous findings have revealed the existence of phagocytic changes after surgery, the factors mediating this response have not been determined. Since phagocytic depression can occur as a result of a depletion of circulating plasma factors called opsonins (14, 15), R E depression after surgical stress may reflect a depression of opsonin activity.In the present study, the involvement of the opsonic system as a factor mediating RE depression after surgery was evaluated. In addition, the time course associated with surgically induced RE alteration as well as the colloid specificity of the response was evaluated.Experimental Methods. Male Holtzman rats (225-350 g) were maintained on Rockland Lab-Tek chow and tap water ad libitum Liver donors were anesthetized with ether and rapidly desanguinated prior to liver removal. The excised liver was chilled in cold isotonic saline prior to liver slice preparation with the use of a Stadie-Riggs tissue slicer

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Section: Discussionmentioning

confidence: 82%

mentioning

confidence: 98%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Mechanism Mediating Reticuloendothelial System Depression After Surgery

Saba¹

1970

Experimental Biology and Medicine

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Physiology and Physiopathology of the Reticuloendothelial System

Saba¹

1970

Arch Intern Med

363

109

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Effect of acute starvation on plasma fibronectin response to sepsis

Cheslyn-Curtis

Aldridge

Dudley

1990

Journal of British Surgery

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There is evidence that undernutrition may contribute to the reduction in plasma fibronectin concentration and the depression of the reticuloendothelial (RE) system associated with severe sepsis. We have investigated the effects of fasting, surgical trauma and sepsis on plasma fibronectin concentrations and RE function. In experiment 1, plasma fibronectin was measured in rabbits (n = 14) before and 48 h after fasting. In experiment 2, sepsis was induced by devascularization of the appendix in animals on a normal diet (sepsis group, n = 7). A third group of animals underwent only a laparotomy (laparotomy only group, n = 7). Plasma fibronectin concentrations and the blood clearance and organ distribution of 99mtechnetium tin colloid (TTC) were measured 24 h after operation. Compared with pooled reference plasma, fasting in experiment 1 resulted in a reduction in mean(s.e.m.) plasma fibronectin concentration from 98(1.5) per cent to 86(3.7) per cent (T = 2, P less than 0.005). Mean(s.e.m.) plasma fibronectin concentration was raised in the sepsis group to 117(4.6) per cent, compared with 97(2.5) per cent in the laparotomy only group (U = 5, P less than 0.02), but there was no such increase in the fasting and sepsis group. There was a delay in the blood clearance and reduced hepatic uptake of TTC in both sepsis groups. The dissociation between fibronectin concentrations and RE function in animal models of sepsis casts doubt on the importance of fibronectin in RE function.

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Involvement of the Opsonic System in Starvation Induced Depression of the Reticuloendothelial System

Cited by 20 publications

References 4 publications

Mechanism Mediating Reticuloendothelial System Depression After Surgery

Mechanism Mediating Reticuloendothelial System Depression After Surgery

Physiology and Physiopathology of the Reticuloendothelial System

Effect of acute starvation on plasma fibronectin response to sepsis

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