Involvement of the oral cavity in psoriasis: results of a clinical study

Ganzetti, Giulia; Campanati, Anna; Santarelli, Andrea; Pozzi, Valentina; Molinelli, Elisa; Minnetti, Ilaria; Brisigotti, Valerio; Procaccini, Maurizio; Emanuelli, Monica; Offidani, Annamaria

doi:10.1111/bjd.13201

Cited by 45 publications

(62 citation statements)

References 9 publications

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“…Other oral findings described in association with psoriasis include angular cheilitis, enlarged fungiform papilla, gingivitis, and periodontitis [4,11,31,32]. Yamada et al [33] reported focal changes in the gingival mucosa and breakdown of proximal periodontal tissues associated with the flares of cutaneous disease, suggesting a potential role for gingival psoriasis in the pathogenesis of the periodontal disease.…”

Section: Histopathological Features Of Oral Psoriasismentioning

confidence: 99%

Oral Psoriasis: An Overlooked Enigma

Fatahzadeh¹,

Schwartz²

2016

Dermatology

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Although cutaneous psoriasis is common, the existence of its manifestations in the oral cavity has been questioned. The definitive diagnosis of oral psoriasis can be challenging due to the variability of presentations, and overlapping clinical and histological features with a number of other conditions as well as the lack of consensus. We review oral psoriasis, noting its variable clinical appearance, delineate the differential diagnosis, and discuss management strategies.

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Section: Histopathological Features Of Oral Psoriasismentioning

confidence: 99%

Oral Psoriasis: An Overlooked Enigma

Fatahzadeh¹,

Schwartz²

2016

Dermatology

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“…The association between psoriasis and periodontitis is consistent with the presence of multiple overlapping characteristics in terms of aggravation factors (e.g., smoking, stress) [18,19], in the composition of inflammatory mediators (e.g., increased levels of IL-17 and TNF-α) [20] and cells (e.g., Υδ T cells, T helper 17 cells, dendritic cells and neutrophil granulocyte rate) [18,21] as well as an increased rate of comorbidities including metabolic diseases, such as diabetes mellitus and obesity, cardiovascular disease, hypertension and myocardial infarction, and autoinflammatory diseases, such as (rheumatoid) arthritis [2]. However, these findings and our data have been mainly gained from observational (case-control-based) studies that cannot identify cause-and-effect relationships.…”

Section: Discussionmentioning

confidence: 55%

The Prevalence of Periodontitis Is Increased in Psoriasis and Linked to Its Inverse Subtype

Painsi

Hirtenfelder²,

Lange‐Asschenfeldt³

et al. 2017

Skin Pharmacol Physiol

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Periodontitis and psoriasis are suggested to be co-occurring, chronic inflammatory conditions with overlapping characteristics. However, respective evidence is rare and data on risk factors of periodontitis in psoriasis patients are minimal. The aim of this study was to expand the evidence of psoriasis-associated periodontitis and establish a potential risk profile for periodontitis. In total, data from 209 exacerbated psoriasis patients were retrospectively analyzed on recordings of periodontitis and compared with those of 91 patients with chronic spontaneous urticaria (CSU). Analysis showed a significantly increased prevalence of periodontitis in psoriasis compared to CSU patients with an odds ratio of 3.76 (95% CI = 1.60-10.27, p = 0.001). Within the psoriatic subtypes, the presence of the inverse type (affecting intertriginous body areas) was strongly linked to periodontitis with an odds ratio of 5.11 (95% CI = 1.36-20.38, p = 0.006). These results are enlarging the evidence for psoriasis-associated periodontitis and identify a link between the inverse type of psoriasis and periodontitis.

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“…[3][4][5][6] Although some authors accept the existence of oral lesions as a manifestation of psoriasis based on their similarity with the skin lesions, others claim that the oral and skin lesions need to be found simultaneously in order to diagnose a psoriatic occurrence. 4,5,7,8 Intraoral lesions are rarely reported, and the first-ever clinical findings reported had no microscopic confirmation. As a result, the number of case descriptions and the incidence of intraoral psoriasis cannot be accurately determined based on the literature.…”

Section: Introductionmentioning

confidence: 99%

“…2,4,6,7 Psoriasiform mucositis presents a variable pattern and may be asymptomatic, revealing an erythematous aspect. [5][6][7] The diagnosis of psoriasiform mucositis is strongly supported by microscopic findings, and biopsy is an essential tool. [4][5][6] Its microscopy shows hyperkeratosis, club-shaped elongation of the rete ridges, thinning of the suprapapillary epithelium, and a chronic inflammatory infiltrate consisting, predominantly, of lymphocytes or neutrophils, depending on the stage of the lesion.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7] The diagnosis of psoriasiform mucositis is strongly supported by microscopic findings, and biopsy is an essential tool. [4][5][6] Its microscopy shows hyperkeratosis, club-shaped elongation of the rete ridges, thinning of the suprapapillary epithelium, and a chronic inflammatory infiltrate consisting, predominantly, of lymphocytes or neutrophils, depending on the stage of the lesion. 6 However, there is no specific microscopic presentation for oral psoriasis, and such features could be shared by other histologically similar diseases.…”

Section: Introductionmentioning

confidence: 99%

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