Involvement of the small intestine in systemic mast cell disease.

Scott, B B; Hardy, G.; Losowsky, M. S.

doi:10.1136/gut.16.11.918

Cited by 38 publications

(3 citation statements)

References 24 publications

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“…In many studies, intestinal villus are blunt and can even sometimes be partially atrophic. [31][32][33][34][35][36] A few cases of total villus atrophy are reported. 37,38 Furthermore, an inflammatory infiltrate in the lamina propria has been observed in many cases.…”

Section: Small Intestinementioning

confidence: 99%

“…This infiltrate consists essentially of plasma cells and eosinophils, 32,35,37,38 and in some cases of a large number of mast cells expressing CD2 and/or CD25. 25,34,36,[38][39][40] Considering the results of radiological studies in the course of SM, macroscopic intestinal lesions seem to be frequent. In a study including esogastroduodenal and small bowel follow-through in 78 patients with SM, 41 the most frequently observed lesion (73% of patients) was 1-3-mm nodules in bowel mucosa, probably related to edema.…”

Section: Small Intestinementioning

confidence: 99%

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Gastrointestinal involvement and manifestations in systemic mastocytosis

Sokol¹,

Georgin‐Lavialle²,

Grandpeix-Guyodo³

et al. 2010

Inflammatory Bowel Diseases

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Mastocytosis is a rare and heterogeneous disease characterized by various biological and clinical features with different prognosis and treatments. The disease is usually divided into 2 categories: a pure cutaneous and a systemic disease. Clinical features can be related to mast cells' mediators release or to pathological mast cells infiltration. The diagnosis of mastocytosis is based on clinical, biological, histological, and molecular international criteria. Among all manifestations of the disease, gastrointestinal (GI) symptoms are common and can significantly impair the quality of life. The aim of this article is to review the data regarding GI involvement in mastocytosis. Articles dealing with clinical, pathophysiological, and therapeutic aspects of mastocytosis GI tract involvement were searched for using PubMed. GI manifestations in mastocytosis are reviewed. Pathogenesis of GI symptoms in systemic mastocytosis and their treatment are critically discussed. The most frequent GI symptoms are abdominal pain, diarrhea, nausea, and vomiting. GI lesions may involve all the digestive tract, from the esophagus to the rectum. The histological diagnosis of GI involvement is difficult. The treatment of GI symptoms aims to prevent and limit mast cells degranulation and/or its consequences and more rarely to control tumoral mast cells infiltration. The high prevalence of GI symptoms in mastocytosis and their important functional impact deserves better characterization and treatment in order to improve patients' quality of life. Diagnosis of mastocytosis GI manifestations should be evoked in the case of unexplained severe GI disorders.

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Section: Small Intestinementioning

confidence: 99%

Section: Small Intestinementioning

confidence: 99%

Gastrointestinal involvement and manifestations in systemic mastocytosis

Sokol¹,

Georgin‐Lavialle²,

Grandpeix-Guyodo³

et al. 2010

Inflammatory Bowel Diseases

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show abstract

“…the commonest gastrointestinal symptom. Two types of abdominal pain -dyspeptic and nondyspeptic -have been Malabsorption, though not severe, is present in up to 30% of patients [28,45,46]. Few patients may have described.…”

Section: Mastocytosis -A Disease Characterized By An Increasedmentioning

confidence: 99%

Systemic Mastocytosis

Karnam

Rogers

1999

Dig Dis

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Mastocytosis is a disease characterized by an abnormal increase in mast cells. Rare in occurrence, protean in its manifestations, it is a disease which is very seldom thought of and hence, possibly even overlooked. The last few decades have witnessed an upsurge in the understanding of the physiology and pathobiology of mast cells. Better means for diagnosis and follow-up have become available. Once a diagnosis is established histamine antagonists remain the mainstay of treatment. Most patients live and die with the disease rather than of it. The objective of this review is to discuss this entity with a special focus on diagnosis and treatment.

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The Abnormal Biopsy

DobbinsIII

1990

Diagnostic Pathology of the Intestinal Mucosa

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Involvement of the small intestine in systemic mast cell disease.

Cited by 38 publications

References 24 publications

Gastrointestinal involvement and manifestations in systemic mastocytosis

Gastrointestinal involvement and manifestations in systemic mastocytosis

Systemic Mastocytosis

The Abnormal Biopsy

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