Involvement of the Urogenital Tract in Patients with Five or More Separate Malignant Neoplasms

Rohde, D.; Jakse, G

doi:10.1159/000019792

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…30 Occasionally, Hodgkin's disease occurs synchronously with other neoplasms, suggesting that like thymoma, some of these patients have an intrinsic predisposition towards additional cancers. 42 Curiously, as this case, a patient with Hodgkin's disease as one of 5 distinct malignant neoplasms has been reported, 13 as has a patient with gliosarcoma developing after Hodgkin's disease. 43 …”

Section: Pathogenesismentioning

confidence: 89%

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Welsh¹,

Thurman²,

Howard³

2003

Clinical Medicine & Research

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The presence of five discrete synchronous or metachronous primary neoplasms in a single patient is an extremely rare event. This is a report of a patient with a malignant (invasive) thymoma and four other independent primary neoplasms including: gliosarcoma, papillary thyroid cancer, meningioma and metastatic adenocarcinoma of the colon, found synchronously at autopsy. Thymoma patients appear to have an inherent predisposition towards developing additional neoplasms. Other than the thymoma, the presented patient had no obvious risk factors for neoplasia. This case provides evidence for an unusual syndrome of thymoma and multiple primary neoplasms. Further research is required to elucidate the mechanism of this association. Meanwhile, heightened awareness of this association may allow earlier detection and treatment of additional cancers in patients with a history of thymoma.

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Section: Pathogenesismentioning

confidence: 89%

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Welsh¹,

Thurman²,

Howard³

2003

Clinical Medicine & Research

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“…Two or more generations should be affected, and one of the colon cancers should have been diagnosed before the age of 50 years. Some families demonstrate a predisposition to transitional cell carcinoma of the bladder, ureter, and renal pelvis but not to renal parenchymal tumors (106). At-risk individuals should be screened with annual urinalysis or cytologic analysis beginning at age 25 years.…”

Section: Hereditary Nonpolyposis Colon Cancermentioning

confidence: 99%

Hereditary Renal Cancers

Choyke¹,

Glenn²,

Walther³

et al. 2003

Radiology

205

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Hereditary renal cancer syndromes can lead to multiple bilateral kidney tumors that occur at a younger age than do nonhereditary renal cancers. Imaging plays an important role in the diagnosis and management of these syndromes. During the past decade, several new hereditary renal syndromes have been discovered but are not yet widely known. Whereas previously, the list of hereditary renal cancers in adults included von Hippel-Lindau disease and a rare form of chromosomal translocation, the list now includes the following syndromes: tuberous sclerosis, hereditary papillary renal cancer, Birt-Hogg-Dubé syndrome, hereditary leiomyoma renal cell carcinoma, familial renal oncocytoma, hereditary nonpolyposis colon cancer, and medullary carcinoma of the kidney. In addition, a number of newly described but poorly understood syndromes are under investigation. Even at this early stage, it is clear that elucidation of the underlying genetic mutations that cause hereditary renal cancer syndromes will have profound implications for understanding the origins of nonhereditary renal tumors. These studies will likely culminate in a better understanding of the causes of renal cancer, its prevention, and, ultimately, its cure.

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“…Recently, extensive pathologic reviews of female cystectomy specimens have suggested that the urethra can be safely preserved in many women as well as men undergoing radical cystectomy, making lower urinary tract reconstruction of the urethra a viable option [1, 2, 3, 4, 5, 6, 7, 8]. Further, detailed neuroanatomical study of the female pelvis has led to improved techniques of radical surgery that preserve continence and voiding function [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Voiding Dysfunction of Sigmoid Neobladder in Women: A Comparative Study with Men

Fujisawa

Isotani²,

Gotoh³

et al. 2001

Eur Urol

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Involvement of the Urogenital Tract in Patients with Five or More Separate Malignant Neoplasms

Cited by 3 publications

References 12 publications

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Hereditary Renal Cancers

Voiding Dysfunction of Sigmoid Neobladder in Women: A Comparative Study with Men

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