“…However, no correlation was found between the degree of bronchodilation provoked by terfenadine and the magnitude of the decrease in responsiveness to propranolol [23]. Our previous study [5] revealed that TxA 2 may also play an important role in the pathogenesis of this reaction. In addition, a recent preliminary study from our group [11] showed that a 5-lipoxygenase inhibitor, AL3264, inhibited the PIB developed after allergic reaction, leading us to examine the role of another lipid mediator, PAF, in the PIB.…”