Involvement of thromboxane but not endothelin-1 in the anaphylataxin-induced increase in glucose output and reduction of flow in perfused rat liver.

Increase by Anaphylatoxin C5a of glucose output in perfused rat liver via prostanoids derived from nonparenchymal cells: Direct action of prostaglandins and indirect action of thromboxane A2 on hepatocytes

“…In SEC/HC cocultures neither rrC5a nor U46619 enhanced glycogen phosphorylase activity; again, stimulation by noradrenaline served as a control (Table 2). In line with this finding, U46619 failed to induce a short-term release of endothelin-1, 28 or platelet-activating factor from SECs (data not shown). Apparently, TXA 2 cannot be involved in the metabolic actions of C5a by inducing the release of an unknown soluble factor from KCs or SECs.…”

“…This conclusion is in line with a previous observation that U46619 induced the release of endothelin-1 from cultured SECs only after hours, but not within minutes. 28 Moreover, U46619 failed to induce the release of platelet-activating factor or PGs from SECs (unpublished observations).…”