Involvement of Thyroid Hormones in the Alterations of T-Cell Immunity and Tumor Progression Induced by Chronic Stress

Frick, Luciana Romina; Rapanelli, Maximiliano; Bussmann, Ursula A.; Klecha, Alicia Juana; Arcos, Marı́a Laura Barreiro; Genaro, Ana Marı́a; Cremaschi, Graciela

doi:10.1016/j.biopsych.2008.12.013

Cited by 47 publications

(29 citation statements)

References 55 publications

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“…Likewise, we believe that the in vivo already-activating effects of THs on cells in hyperthyroid mice may have led to a weaker antigenic response to in vitro T4 treatment as compared to that evidenced by cells in euthyroid mice. These findings are in agreement with data reported by other investigators (see Fricks et al, 2009;Karanikas et al, 2004;Klecha et al, 2006;Yao et al, 2007) who, in general, demonstrated that in vitro T4 treatment or alterations in the normal thyroid gland state impacted on the proliferative and synthetic activities of lymphocytes.…”

Section: Discussionsupporting

confidence: 93%

Hyperthyroid state orin vitrothyroxine treatment modulates T_H1/T_H2 responses during exposure to HSV-1 antigens

Varedi¹,

Shiri²,

Moattari³

et al. 2013

Journal of Immunotoxicology

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Increasingly in recent years, thyroid hormones (THs) have been considered to be important regulators of the immune system. However, their roles in host defense against viral infections are not clearly established. Therefore, this study was undertaken to examine proliferative activity and cytokine production by lymphocytes isolated from hyperthyroid and euthyroid Balb/c mice in response to herpes simplex virus-1 (HSV-1). Lymphocytes of hyperthyroid animals showed a significantly higher rate of proliferation and interferon (IFN)-g production when compared with that by lymphocytes from euthyroid mice. In vitro thyroxine (T4) treatment was similarly effective in the potentiation of proliferation, but not IFNg production, by euthyroid lymphocytes. Furthermore, the hyperthyroid state significantly attenuated ConA-, but not HSV-1-, induced interleukin (IL)-10 release; in vitro T4 treatment synergized this effect. These findings suggest that supra-physiologic TH levels (i.e. as occur in hyper-thyroid states) or in vitro TH treatment modulate T-helper (T H )1/T H 2 lymphocyte responses and thereby amplifies host defenses against viral infections. One may also conclude that THs may have a potential application in viral immunization and/or treatment of viral infections.

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Section: Discussionsupporting

confidence: 93%

Hyperthyroid state orin vitrothyroxine treatment modulates T_H1/T_H2 responses during exposure to HSV-1 antigens

Varedi¹,

Shiri²,

Moattari³

et al. 2013

Journal of Immunotoxicology

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“…Previous studies have demonstrated that physical restrain decreases peripheral blood lymphocyte and mitogen-induced proliferation in rats and produces changes in T cell functional capacity [26,10]. In the present study, decreased response of lymphoproliferation was not observed in restrained rats.…”

Section: Resultscontrasting

confidence: 47%

Taurine and proliferation of lymphocytes in physically restrained rats

2010

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BackgroundTaurine is present in lymphocytes and seems to modulate certain immune cell functions. Among the effects of taurine on these cells are protection against antioxidants and regulation of inflammatory aspects of the immune response. Stress affects antigen presentation, traffic and proliferation of leukocytes, as well as antibody and cytokine secretion. The purposes of this study were to explore the possible direct effects of taurine concentrations on lymphoproliferation and interleukins levels in control and in physical restrained rats.MethodsLymphocytes of male Sprague-Dawley rats, stressed by physical restrain and controls (5 h per day for 5 days) were isolated from blood by Histopaque (1077 g/l) and differential adhesion to plastic, and then cultured (72 h) in the presence of different concentrations of taurine (0.5 – 50 mM), β-alanine (0.5 – 50 mM), or both, without or with the T cells mitogen, concanavalin A. Plasma and lymphocytes levels of pro-inflammatory interleukin-1β and anti-inflammatory interleukin-10 were respectively measured by Pierce Endogen rat ELISA Kits. Taurine in plasma and in lymphocytes were determined by HPLC.ResultsLymphoproliferation of resting cells significantly decreased in the presence of 3 and 6 mM taurine and increased up to control level at 12 mM taurine. In concanavalin A-activated lymphocytes, the effect of taurine was greater. β-alanine increased lymphoproliferation in a bell shaped dose-dependent manner and decreased it in activated lymphocytes but in a lower magnitude. In combination, β-alanine impaired the effect of taurine at 3 and 6 mM. After restriction, no change in lymphoproliferation was observed at different concentrations of the amino acids without or with concanavalin A, although pro-inflammatory interleukin and taurine in plasma and in lymphocytes significantly increased.ConclusionsTaurine affects lymphoproliferation in control rats, following a dose-dependent manner, an effect that might involve its transport into the cells. Elevation of interleukin-1β produced in stressed rats by physical restrain could seriously affect the immune balance, whereas taurine increase might be protective. These results suggest that taurine and taurine transport play a role in lymphoproliferation. In addition, modifications of taurine system in lymphocytes take place during restriction stress.

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“…Forty years later, studies have shown which specific lymphocyte subsets are affected (Pacheco-Lopez et al, 2009), and much more is known generally about stress effects on the immune system (Dhabhar, 2014). While many studies have demonstrated that acute stress and chronic stress differentially affect immunity (Dhabhar, 2009; Segerstrom and Miller, 2004), we will focus primarily on chronic stress because it is more strongly associated with depression (Phillips et al, 2015) and is known to suppress adaptive immunity—reducing lymphocyte proliferation and altering T cell subtype ratios and functionality (Bartolomucci, 2007; Dominguez-Gerpe and Rey-Mendez, 2001; Edgar et al, 2003; Frick et al, 2009a; Frick et al, 2009b; Schmidt et al, 2010; Silberman et al, 2004; Silberman et al, 2002). More recent studies showed that mice exposed to chronic mild stress had a decline in the Th1/Th2 ratio, extrapolated from relative changes in cytokine output, and a corresponding decline in cognitive performance on the Y-maze (Palumbo et al, 2012).…”

Section: Adaptive Immunity In Affective Disordersmentioning

confidence: 99%

Contributions of the adaptive immune system to mood regulation: Mechanisms and pathways of neuroimmune interactions

Herkenham

Kigar

2017

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Clinical and basic studies of functional interactions between adaptive immunity, affective states, and brain function are reviewed, and the neural, humoral, and cellular routes of bidirectional communication between the brain and the adaptive immune system are evaluated. In clinical studies of depressed populations, lymphocytes—the principal cells of the adaptive immune system—exhibit altered T cell subtype ratios and CD4+ helper T cell polarization profiles. In basic studies using psychological stress to model depression, T cell profiles are altered as well, consistent with stress effects conveyed by the hypothalamic-pituitary-adrenal axis and sympathetic nervous system. Lymphocytes in turn have effects on behavior and CNS structure and function. CD4+ T cells in particular appear to modify affective behavior and rates of hippocampal dentate gyrus neurogenesis. These observations force the question of how such actions are carried out. CNS effects may occur via cellular and molecular mechanisms whereby effector memory T cells and the cytokine profiles they produce in the blood interact with the blood-brain barrier in ways that remain to be clarified. Understanding the mechanisms by which T cells polarize and interact with the brain to alter mood states is key to advances in the field, and may permit development of therapies that target cells in the periphery, thus bypassing problems associated with bioavailability of drugs within the brain.

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Involvement of Thyroid Hormones in the Alterations of T-Cell Immunity and Tumor Progression Induced by Chronic Stress

Cited by 47 publications

References 55 publications

Hyperthyroid state orin vitrothyroxine treatment modulates T_H1/T_H2 responses during exposure to HSV-1 antigens

Hyperthyroid state orin vitrothyroxine treatment modulates T_H1/T_H2 responses during exposure to HSV-1 antigens

Taurine and proliferation of lymphocytes in physically restrained rats

Contributions of the adaptive immune system to mood regulation: Mechanisms and pathways of neuroimmune interactions

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Involvement of Thyroid Hormones in the Alterations of T-Cell Immunity and Tumor Progression Induced by Chronic Stress

Cited by 47 publications

References 55 publications

Hyperthyroid state orin vitrothyroxine treatment modulates TH1/TH2 responses during exposure to HSV-1 antigens

Hyperthyroid state orin vitrothyroxine treatment modulates TH1/TH2 responses during exposure to HSV-1 antigens

Taurine and proliferation of lymphocytes in physically restrained rats

Contributions of the adaptive immune system to mood regulation: Mechanisms and pathways of neuroimmune interactions

Contact Info

Product

Resources

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Hyperthyroid state orin vitrothyroxine treatment modulates T_H1/T_H2 responses during exposure to HSV-1 antigens

Hyperthyroid state orin vitrothyroxine treatment modulates T_H1/T_H2 responses during exposure to HSV-1 antigens