Involvement of TLR4 in the protective effect of intra-articular administration of curcumin on rat experimental osteoarthritis

Yan, Dan; He, Bingshu; Guo, Jie; Li, Shulan; Wang, Jun

doi:10.1590/s0102-865020190060000004

Cited by 27 publications

(32 citation statements)

References 26 publications

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“…A recent study conducted by Yan et al [168] suggested that the aforementioned beneficial role of curcumin administration in OA may be related to the inhibition of TLR-4 signal. Indeed, TLR-4 plays an important role in the pathogenesis of OA [169]. Several damage-associated molecular patterns (DAMPs) generated from cartilage damage can activate TLR-4 [169].…”

Section: Cur and Tlr-4 In Rheumatic Diseases Inflammatory Arthritic Dmentioning

confidence: 99%

“…Indeed, TLR-4 plays an important role in the pathogenesis of OA [169]. Several damage-associated molecular patterns (DAMPs) generated from cartilage damage can activate TLR-4 [169]. Moreover, the expression of TLR-4 in joint tissues increases with increasing severity of OA; this leads to inflammatory and catabolic responses by chondrocytes, represented by enhanced expression of inflammatory cytokines such as IL-1, IL-6, TNFα, and matrix metalloproteinase (MMP), release of nitric oxide (NO), and prostaglandin E2 (PGE2) synthesis, which are mediated by NF-κB [168][169][170].…”

Section: Cur and Tlr-4 In Rheumatic Diseases Inflammatory Arthritic Dmentioning

confidence: 99%

“…Several damage-associated molecular patterns (DAMPs) generated from cartilage damage can activate TLR-4 [169]. Moreover, the expression of TLR-4 in joint tissues increases with increasing severity of OA; this leads to inflammatory and catabolic responses by chondrocytes, represented by enhanced expression of inflammatory cytokines such as IL-1, IL-6, TNFα, and matrix metalloproteinase (MMP), release of nitric oxide (NO), and prostaglandin E2 (PGE2) synthesis, which are mediated by NF-κB [168][169][170]. TRL-4 is also involved in the age-related and mechanical stress-related OA, as the accumulation of advanced glycation end products, typical of aging, enhances the expression of catabolic factors by chondrocytes via TLR-4 [171] and shear stress induces a rapid and transient expression of TLR-4 by chondrocytes [172].…”

Section: Cur and Tlr-4 In Rheumatic Diseases Inflammatory Arthritic Dmentioning

confidence: 99%

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The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties

Panaro

Corrado

Benameur

et al. 2020

IJMS

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Natural products have been used in medicine for thousands of years. Given their potential health benefits, they have gained significant popularity in recent times. The administration of phytochemicals existed shown to regulate differential gene expression and modulate various cellular pathways implicated in cell protection. Curcumin is a natural dietary polyphenol extracted from Curcuma Longa Linn with different biological and pharmacological effects. One of the important targets of curcumin is Toll-like receptor-4 (TLR-4), the receptor which plays a key role in the modulation of the immune responses and the stimulation of inflammatory chemokines and cytokines production. Different studies have demonstrated that curcumin attenuates inflammatory response via TLR-4 acting directly on receptor, or by its downstream pathway. Curcumin bioavailability is low, so the use of exosomes, as nano drug delivery, could improve the efficacy of curcumin in inflammatory diseases. The focus of this review is to explore the therapeutic effect of curcumin interacting with TLR-4 receptor and how this modulation could improve the prognosis of neuroinflammatory and rheumatic diseases.

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Section: Cur and Tlr-4 In Rheumatic Diseases Inflammatory Arthritic Dmentioning

confidence: 99%

Section: Cur and Tlr-4 In Rheumatic Diseases Inflammatory Arthritic Dmentioning

confidence: 99%

Section: Cur and Tlr-4 In Rheumatic Diseases Inflammatory Arthritic Dmentioning

confidence: 99%

See 1 more Smart Citation

The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties

Panaro

Corrado

Benameur

et al. 2020

IJMS

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“…Curcumin is widespread in many Asian cuisines as well as in Ayurvedic medicine [60]. Besides that, the antioxidant and anti-inflammatory properties of curcumin are well known [61], dealing with various pathologies such arthritis and osteoarthritis [62][63][64][65][66][67], obesity and diabetes [68,69]. In addition to its very low bioavailability, the real mechanism of action of curcumin is still uncertain.…”

Section: Nutritional Supplementsmentioning

confidence: 99%

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

et al. 2019

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Epidemiologic studies suggest that dietary polyphenol intake is associated with a lower incidence of several non-communicable diseases. Although several foods contain complex mixtures of polyphenols, numerous factors can affect their content. Besides the well-known capability of these molecules to act as antioxidants, they are able to interact with cell-signaling pathways, modulating gene expression, influencing the activity of transcription factors, and modulating microRNAs. Here we deeply describe four polyphenols used as nutritional supplements: quercetin, resveratrol, epigallocatechin gallate (ECGC), and curcumin, summarizing the current knowledge about them, spanning from dietary sources to the epigenetic capabilities of these compounds on microRNA modulation.

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“…In ammation contributes to chondrocyte apoptosis, extracellular matrix disruption, and cartilage degeneration through the pro-in ammatory cytokines IL1β, IL6, and TNF-α [58][59][60][61][62][63][64]. Curcumin has been suggested to suppress in ammation and prevent cartilage destruction by reducing the activation of the NF-κB pathway and proin ammatory cytokine expression [25,[65][66][67].…”

Section: Anti-in Ammatory Effect and Articular Cartilage Ameliorated mentioning

confidence: 99%

Periodic Curcumin Monoglucuronide Injections Ameliorate Structural Osteoarthritis Changes in Rats with Destabilized Medial Meniscus

Nakahata¹,

Itô²,

Nakahara³

et al. 2020

Preprint

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Background: Curcumin has anti-inflammatory effects. However, curcumin is poorly water-soluble, and when administered orally, formscurcumin conjugates with poor efficacy.Curcumin monoglucuronide (TBP1901) is highly water-soluble and can existinthe free-form in a greater proportion than curcumin in vivo. This study aimed to evaluate the effectiveness of intra-articular TBP1901 injections fora rat model of osteoarthritis (OA).Methods: Sixty-four male Wistar rats (12weeks old) that had receivedthe destabilized medial meniscus(DMM) surgery, were randomly separatedinto the TBP1901 injectionandthe saline solution injection (control) group. They were sacrificedat 1, 2, 6, or 10weeks postoperatively(n = 8 for each). The TBP1901 (30mg/mL) andsaline solutionof 50μLwere administered to the knee joint through the patella tendon twice a week for the rats sacrificedat1 and 2weeks or once a week for at6 and 10weeks. The OA changes were evaluated by micro-computed tomography (micro-CT), histology, and immunohistochemical analysis.Results:Curcumin fluorescence was confirmed in the articular cartilageand synovium of rats with TBP1901 injections at all observation periods.The TBP1901injections significantly reducedthe synovial inflammation at 1 and 2 weeks and the expression of TNFα in thetibialarticular cartilage at 6 weeks postoperatively.Moreover, TBP1901 injections ameliorated the articular cartilage structure, the subchondral bone (SB) plate thickness, and perforations from 6 to 10 weeks.As a result, there were significant differencesbetween groups in OA scores, SB plate thickness, and perforations at 10 weeks postoperatively.In addition, osteophyte formation in the TBP1901group was significantly suppressed after 10 weeks.Conclusion: This study reports the first evidence that TBP1901 injections suppress inflammation and osteophyte formation, and ameliorate the articular cartilage and SB pathologies by absorption in the articular cartilage and synovium in a rat DMM model.Therefore, intra-articular injections of TBP1901may be effective in improving OA pathology.

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Involvement of TLR4 in the protective effect of intra-articular administration of curcumin on rat experimental osteoarthritis

Abstract: and Technology, China. Design of the study, manuscript writing, critical revision, supervised all phases of the study.

Cited by 27 publications

References 26 publications

The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties

The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties

Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

Periodic Curcumin Monoglucuronide Injections Ameliorate Structural Osteoarthritis Changes in Rats with Destabilized Medial Meniscus

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