Involvement of Uterine Cervix as the First Manifestation of Granulomatosis With Polyangiitis

Caron, François; Michaud, Raymonde; Gariépy, Gilles; Bourré‐Tessier, Josiane

doi:10.1097/rhu.0000000000000193

Cited by 3 publications

(6 citation statements)

References 9 publications

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“…Our systematic review identified 19 patients with GPA and genital tract involvement [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Among them 11/19 (58%) had primary disease, and 8/19 (42%) had recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…The most common clinical presentation of primary GPA is that of a gynecologic malignancy, as noted in 68% of the studies reviewed [2,[16][17][18][19][22][23][24][26][27][28][29][30]. Some of these patients received incorrect treatments such as surgical excision, anti-tuberculosis treatment, and/or radiotherapy [13][14][15]18,20,21,24,28].…”

Section: Discussionmentioning

confidence: 99%

“…Once studies with patients with MPA or EGPA (5) were removed, a total of 17 studies fulfilled all inclusion criteria and were selected for full-text evaluation and systematic review [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. After reviewing the 17 articles, 18 patients were identified as GPA with gynecological involvement (two patients reported by Stone et al) [12].…”

Section: Main Findingsmentioning

confidence: 99%

“…The results are shown in Tables 1 and 2. In thirteen of the 19 patients (68%) [14][15][16][17][18][20][21][22][24][25][26][27][28],including our case, the authors considered gynecologic cancer as the first possibility of diagnosis. Among them, 11 (58%) thought they were dealing with cervical cancer [14][15][16][17][18]21,22,[24][25][26][27][28].…”

Section: Main Findingsmentioning

confidence: 99%

“…In thirteen of the 19 patients (68%) [14][15][16][17][18][20][21][22][24][25][26][27][28],including our case, the authors considered gynecologic cancer as the first possibility of diagnosis. Among them, 11 (58%) thought they were dealing with cervical cancer [14][15][16][17][18]21,22,[24][25][26][27][28]. Isolated genital involvement and multi-site involvement were present in 10 and in 9 out of 19 patients, respectively (43%).…”

Section: Main Findingsmentioning

confidence: 99%

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Granulomatosis with Polyangiitis-Mimicking Advanced Gynecological Cancer: A Case Report and Systematic Review of the Literature

Pereira

Magrina

Magtibay

et al. 2022

JPM

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(1) Background: Granulomatosis with polyangiitis (GPA) is a necrotizing vasculitis that mimics gynecologic cancer. In GPA patients, the genitourinary system is affected in <1%. The objective of the study was to provide a systematic review of the literature of GPA patients with gynecological involvement. (2) Methods: PubMed and Embase were searched from inception to July 2021 for GPA patients with gynecological involvement Medical Subject Headings (MeSH) and free-text terms. Exclusion criteria were other language, review articles, pregnancy, fertility, or male patients. Data were extracted on clinical evolution, symptoms, examinations findings, diagnosis delay, treatment, outcome, patient status, and follow-up. (3) Results: Seventeen studies included data from patients with GPA and primary or relapsed gynecological involvement. 68% of the authors of this review thought the patient had cancer. The main gynecological symptom is bleeding, but exclusive gynecologic symptomatology is rare (ENT: 63%, lungs: 44%, kidneys-urinary tract: 53%). GPA could affect all areas of the genital tract, but the most frequent location is the uterine cervix. Medical treatment for GPA is effective. (4) Conclusions: GPA of the female genital tract must be considered when biopsies of an ulcerated malignant-appearing cervical or vaginal mass are negative for malignancy even when they are unspecific. Rheumatology consultation is indicated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Main Findingsmentioning

confidence: 99%

Section: Main Findingsmentioning

confidence: 99%

Section: Main Findingsmentioning

confidence: 99%

See 3 more Smart Citations

Granulomatosis with Polyangiitis-Mimicking Advanced Gynecological Cancer: A Case Report and Systematic Review of the Literature

Pereira

Magrina

Magtibay

et al. 2022

JPM

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Vascularite des artères utérines révélant une artérite à cellules géantes : cas clinique et revue de la littérature

Guillotin¹,

Mercié²,

Duffau³

2022

La Revue de Médecine Interne

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An Unusual Case of Vulvar Involvement in the Course of Granulomatosis with Polyangiitis

Nowak

Kozłowski

Piekara

et al. 2022

IJERPH

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Granulomatosis with polyangiitis is a rare autoimmune disease with the presence of c-ANCA in most cases. It involves necrotizing inflammation in small and medium-sized vessels with multiple granulomas. The disease can affect many systems, but the typical triad of attacked systems are the upper and lower respiratory tracts and kidneys, with varying degrees of severity. Involvement of the respiratory tract may manifest, among other symptoms, as nasal crusting, nosebleeds, and dyspnea. Among patients with granulomatosis with polyangiitis, only less than 1% develop genitourinary system involvement. We present a case study of a 36-year-old woman with an 8-year-long GPA history and a lesion, which, due to its appearance and accompanying symptoms, aroused the suspicion of a neoplasm but was proven to be a granuloma with a nontypical location. The systemic disease was treated with glucocorticosteroids and cyclophosphamide. The lesion on the labium minus was surgically removed. We concluded that the macroscopic picture of GPA of the vulva and vulvar cancer is similar. The patient’s medical history may help differentiate GPA and vulvar cancer. Although vulvar GPA is extremely rare, it should be considered in the differential diagnosis of vulvar lesions, especially those suspected to be oncological.

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Involvement of Uterine Cervix as the First Manifestation of Granulomatosis With Polyangiitis

Cited by 3 publications

References 9 publications

Granulomatosis with Polyangiitis-Mimicking Advanced Gynecological Cancer: A Case Report and Systematic Review of the Literature

Granulomatosis with Polyangiitis-Mimicking Advanced Gynecological Cancer: A Case Report and Systematic Review of the Literature

Vascularite des artères utérines révélant une artérite à cellules géantes : cas clinique et revue de la littérature

An Unusual Case of Vulvar Involvement in the Course of Granulomatosis with Polyangiitis

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