Involvement of α1-adrenoceptors in conditioned place preference supported by nicotine in rats

Forget, Benoît; Hamon, Michel; Thiébot, Marie-Hélène

doi:10.1007/s00213-009-1559-7

Cited by 24 publications

(19 citation statements)

References 67 publications

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“…These findings are consistent with previous results demonstrating that adolescents are more sensitive than adults to the rewarding properties of drugs of abuse (Brenhouse & Andersen, 2008;Zakharova, Wade, & Izenwasser, 2009), including nicotine (Torres et al, 2008). While CPP conditioning procedures often use an unbiased design (Cunningham, Henderson, & Bormann, 1998;Forget, Hamon, & Thi ebot, 2009;Wilkinson & Bevins, 2008), the current experiment used a biased two-compartment design in which nicotine was paired with the initially nonpreferred compartment of the apparatus (Brielmaier, McDonald, & Smith, 2012). While not supporting the emergence of significant nicotine CPP in adult males, this procedure was very sensitive to the expression of age differences in nicotine CPP, with robust nicotineinduced increases in time spent in the paired side among the adolescent animals.…”

Section: Discussionsupporting

confidence: 91%

“…As was hypothesized, adolescents displayed CPP at all doses of nicotine, whereas significant place conditioning was not evident in adults (see Fig. While CPP conditioning procedures often use an unbiased design (Cunningham, Henderson, & Bormann, 1998;Forget, Hamon, & Thi ebot, 2009;Wilkinson & Bevins, 2008), the current experiment used a biased two-compartment design in which nicotine was paired with the initially nonpreferred compartment of the apparatus (Brielmaier, McDonald, & Smith, 2012). These findings are consistent with previous results demonstrating that adolescents are more sensitive than adults to the rewarding properties of drugs of abuse (Brenhouse & Andersen, 2008;Zakharova, Wade, & Izenwasser, 2009), including nicotine (Torres et al, 2008).…”

Section: Discussionmentioning

confidence: 77%

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Age differences in conditioned place preferences and taste aversions to nicotine

Dannenhoffer

Spear

2016

Developmental Psychobiology

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Adolescents and adults differ in their behavioral sensitivities to drugs of abuse, including nicotine. Studies have shown that both rewarding and aversive properties of drugs of abuse can exist concomitantly. The present study investigated the ontogeny of these opposing qualities across a range of doses using a combined conditioned taste aversion and place preference paradigm in pair-housed rats that were not deprived of food or water. Results indicated that adolescents were more sensitive to the rewarding properties of nicotine than adults. In contrast, although all doses produced a taste aversion at both ages in the same rats, the aversion was weaker at lower than high doses in adolescents whereas adults showed strong aversion at all doses, suggesting modest attenuation in nicotine's aversive properties among adolescents relative to adults. Thus, attenuated aversive and accented appetitive sensitivities of adolescents to nicotine can be experienced simultaneously in the same animals. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58: 660-666, 2016.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 77%

Age differences in conditioned place preferences and taste aversions to nicotine

Dannenhoffer

Spear

2016

Developmental Psychobiology

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“…It is unlikely that these drugs produced aversive effects, which might have inhibited 50-kHz calling. Clonidine, for example, is self-administered IV (Davis and Smith, 1977) and induces CPP (Asin and Wirtshafter, 1985;Cervo et al, 1993) in rats, whereas prazosin seems motivationally neutral (Forget et al, 2009;Zarrindast et al, 2002). The inhibitory effect of prazosin is potentially interesting in view of its reported failure to block either the discriminative stimulus effects of AMPH in rats (Arnt, 1996;West et al, 1995) or the acquisition of AMPH CPP (Hoffman and Donovan, 1995).…”

Section: Behavioral Considerationsmentioning

confidence: 96%

α- and β-Adrenergic Receptors Differentially Modulate the Emission of Spontaneous and Amphetamine-Induced 50-kHz Ultrasonic Vocalizations in Adult Rats

Wright

Dobosiewicz

Clarke

2011

Neuropsychopharmacol

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Amphetamine (AMPH) increases adult rat 50-kHz ultrasonic vocalizations, preferentially promoting frequency-modulated (FM) calls that have been proposed to reflect positive affect. The main objective of this study was to investigate a possible noradrenergic contribution to AMPH-induced calling. Adult male Long-Evans rats were tested with AMPH (1 mg/kg intraperitoneal) or saline combined with various systemic pretreatments: clonidine (α2 adrenergic agonist), prazosin (α1 antagonist), atipamezole (α2 antagonist), propranolol, betaxolol, and/or ICI 118,551 (β1/β2, β1, and β2 antagonists, respectively), nadolol (β1/β2 antagonist, peripheral only), or NAD-299 (5HT(1A) antagonist). In addition, effects of cirazoline (α1 adrenergic agonist) and cocaine (0.25-1.5 mg/kg intravenous) were studied alone. AMPH-induced calling was suppressed by low-dose clonidine and prazosin. Cirazoline and atipamezole did not significantly affect calling rate. Propranolol, without affecting the call rate, dose dependently promoted 'flat' calls under AMPH while suppressing 'trills,' thus reversing the effects of AMPH on the 'call subtype profile.' This effect of propranolol seemed to be mediated by simultaneous inhibition of CNS β1 and β2 rather than by 5HT(1A) receptors. Finally, cocaine elicited fewer calls than did AMPH, but produced the same shift in the call subtype profile. Taken together, these results reveal differential drug effects on flat vs trill vs other FM 50-kHz calls. These findings highlight the value of detailed call subtype analyses, and show that 50-kHz calls are associated with adrenergic α1- and β-receptor mechanisms. These preclinical findings suggest that noradrenergic contributions to psychostimulant subjective effects may warrant further investigation.

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“…However, we do not believe it was an issue. Indeed, microdialysis experiments performed in non-human primates or rodents indicate that elevation of dopamine are almost at maximal level at the time-point we selected for the beginning of the scanning time, and elevation of dopamine are prolonged and can last at least 2 hours in some reports (Domino and Tsukada, 2009;Forget et al, 2009). We also did not use denicotinized cigarette as a control.…”

Section: (C) Expectancy Factor (Tobacco Craving Questionnaire Tcq)mentioning

confidence: 99%

Elevation of Dopamine Induced by Cigarette Smoking: Novel Insights from a [11C]-(+)-PHNO PET Study in Humans

Foll

Guranda

Wilson

et al. 2013

Neuropsychopharmacol

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Positron emission tomography (PET) has convincingly provided in vivo evidence that psychoactive drugs increase dopamine (DA) levels in human brain, a feature thought critical to their reinforcing properties. Some controversy still exists concerning the role of DA in reinforcing smoking behavior and no study has explored whether smoking increases DA concentrations at the D3 receptor, speculated to have a role in nicotine's addictive potential. Here, we used PET and]oxazin-9-ol) to test the hypothesis that smoking increases DA release (decreases [ 11 C]-( þ )-PHNO binding) in D2-rich striatum and D3-rich extra-striatal regions and is related to craving, withdrawal and smoking behavior. Ten participants underwent [ 11 C]-( þ )-PHNO scans after overnight abstinence and after smoking a cigarette. Motivation to smoke (smoking topography), mood, and craving were recorded. Smoking significantly decreased self-reported craving, withdrawal, and [ 11 C]-( þ )-PHNO binding in D2 and D3-rich areas ( À 12.0 and À 15.3%, respectively). We found that motivation to smoke (puff rate) predicted magnitude of DA release in limbic striatum, and the latter was correlated with decreased craving and withdrawal symptoms. This is the first report suggesting that, in humans, DA release is increased in D3-rich areas in response to smoking. Results also support the preferential involvement of the limbic striatum in motivation to smoke, anticipation of pleasure from cigarettes and relief of withdrawal symptoms. We propose that due to the robust effect of smoking on [ 11 C]-( þ )-PHNO binding, this radiotracer represents an ideal translational tool to investigate novel therapeutic strategies targeting DA transmission.

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Involvement of α1-adrenoceptors in conditioned place preference supported by nicotine in rats

Cited by 24 publications

References 67 publications

Age differences in conditioned place preferences and taste aversions to nicotine

Age differences in conditioned place preferences and taste aversions to nicotine

α- and β-Adrenergic Receptors Differentially Modulate the Emission of Spontaneous and Amphetamine-Induced 50-kHz Ultrasonic Vocalizations in Adult Rats

Elevation of Dopamine Induced by Cigarette Smoking: Novel Insights from a [11C]-(+)-PHNO PET Study in Humans

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