IOC consensus paper on the use of platelet-rich plasma in sports medicine

Engebretsen, Lars; Steffen, Kathrin; Alsousou, Joseph; Anitua, Eduardo; Bachl, Norbert; Devilee, Roger J.J.; Everts, Peter A.; Hamilton, Bruce; Huard, Johnny; Jenoure, Peter; Kelberine, F; Kon, Elizaveta; Maffulli, Nicola; Matheson, Gordon O.; Mei-Dan, Omer; Ménétrey, Jacques; Philippon, Marc J.; Randelli, Pietro; Schamasch, Patrick; Schwellnus, Martin; Vernec, Alan; Verrall, Geoffrey M.

doi:10.1136/bjsm.2010.079822

Cited by 241 publications

(199 citation statements)

References 89 publications

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“…The 2010 International Olympic Committee consensus paper on the use of PRP in sports medicine concluded that PRP is a treatment option for chronic tendon injuries [14]. However, further study is required to identify the optimal PRP preparation, dosing protocol, and timing for various tendon disorders.…”

Section: Clinical Studiesmentioning

confidence: 99%

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The Role of Platelet-Rich Plasma in Inducing Musculoskeletal Tissue Healing

Halpern¹,

Chaudhury²,

Rodeo³

2012

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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Background Platelet-rich plasma [PRP] has received increasing interest across many musculoskeletal disciplines and has been widely applied clinically to stimulate tissue healing in numerous anatomical regions. The known actions of platelet-derived factors suggest that PRP may have significant potential in the treatment of pathological conditions of cartilage, tendon, ligament, and muscle. Purpose The aim of this manuscript is to review current literature regarding the biology of PRP and the efficacy of using PRP to augment healing of tendon ligament and muscle injuries, as well as early osteoarthritis. Methods A comprehensive literature review of musculoskeletal applications of PRP was performed, including basic science and clinical studies such as randomized controlled trials, case controlled series, and case series. Results The most compelling evidence to support the efficacy of PRP is for its application to tendon damage associated with lateral and medial epicondylitis. Although some promising studies have been reported supporting the use of PRP in osteoarthritis and ligament and muscle injuries, it currently remains unknown whether PRP effectively alters the progression of osteoarthritis or aids the healing of ligament and muscle tissues. Conclusion The rationale for the use of PRP to improve tissue healing is strong, but the efficacy for many musculoskeletal applications remains unproven. PRP has been shown to be a safe treatment. A number of questions regarding PRP remain unanswered, including the optimal concentration of platelets, what cell types should be present, the ideal frequency of application, or the optimal rehabilitation regimen for tissue repair and return to full function.

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Section: Clinical Studiesmentioning

confidence: 99%

“…This was a retrospective study with no untreated control patients. However, the 2010 International Olympic Committee consensus paper on the use of PRP in sports medicine concluded that there was little scientific support for the use of PRP in muscle strain injuries [14].…”

Section: Applicability Of Prp Therapies To Muscle Injuriesmentioning

confidence: 99%

The Role of Platelet-Rich Plasma in Inducing Musculoskeletal Tissue Healing

Halpern¹,

Chaudhury²,

Rodeo³

2012

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

View full text Add to dashboard Cite

show abstract

“…The evidence base to guide the use of PRP in the treatment of contusion injuries and muscle strains is very limited. An International Olympic Committee (IOC) consensus paper on the use of PRP in sports medicine indicated there is little scientific support for PRP in the treatment of muscle strain injury and suggested further investigation utilizing this technology is needed to develop practice guidelines [2].…”

Section: Introductionmentioning

confidence: 99%

Platelet-rich plasma for muscle injuries: game over or time out?

Mosca

Rodeo

2015

Curr Rev Musculoskelet Med

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Muscle injuries are common and may be associated with impaired functional capacity, especially among athletes. The results of healing with conventional therapy including rest, ice, compression, and elevation (RICE) are often inadequate, generating substantial interest in the potential for emerging technologies such as platelet-rich plasma (PRP) to enhance the process of soft-tissue healing and to decrease time to recovery. In vitro studies and animal research have suggested that PRP may have benefits associated with the increased release of cytokines and growth factors resulting from supraphysiological concentrations of platelets that facilitate muscle repair, regeneration, and remodeling. Despite the promise of basic science, there is a paucity of clinical data to support the theoretical benefits of PRP. The only double-blind controlled clinical trial was recently reported and showed no benefit of PRP in the time to resume sports activity among athletes with hamstring muscle injury. This review examines the current evidence and the theoretical framework for PRP and muscle healing. Scientific gaps and technological barriers are discussed that must be addressed if the potential promise of PRP as a therapeutic modality for muscle injury is to be realized.

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“…The alpha granules are the most studied platelet structures (each platelet has 50-80 alpha units, and each granule has more than 30 bioactive proteins that can be released by a stimulus). There are different subpopulations of alpha granules, and an early release of these granules by activation with thrombin may promote an exacerbated reaction, leading to the antagonistic action of growth factors, and these factors should be released at different stages of the healing process 15 . In addition, the previous activation can limit the percutaneous application, which is the preferred route used in conservative treatment, owing to the gelation PRP after activation.…”

mentioning

confidence: 99%

Biomechanical study of the effect of platelet rich plasma on the treatment of medial collateral ligament lesion in rabbits

Costa

Teixeira²,

Pádua³

et al. 2017

Acta Cir. Bras.

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Purpose: To evaluate the use of platelet-rich plasma in the early stages of healing of traumatic injury of the medial collateral ligament in the knee of rabbits. Methods: Thirty rabbits were subjected to surgical lesion of the medial collateral ligament. Of these, 16 were treated with platelet-rich plasma and 14 with saline (control). After 3 and 6 weeks of treatment, 50% of the animals from each group were sacrificed, and biomechanical tests were performed on the injured ligament to compare the tensile strength between the two groups. Results: Platelet-rich plasma significantly increased the tensile strength of the ligament in the groups treated after3 and 6 weeks. In the group treated with platelet-rich plasma vs. saline, the tensile strength values were 3192.5 ± 189.7 g/f vs. 2851.1 ± 193.1 g/f at3 weeks (p = 0.005) and 5915.6 ± 832.0 g/f vs. 4187.6 ± 512.9 g/f at 6 weeks (p = 0.0001). Conclusion:The use of platelet-rich plasma at the injury site accelerated ligament healing in an animal model, demonstrated by an increase in the tensile strength of the medial collateral ligament.

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IOC consensus paper on the use of platelet-rich plasma in sports medicine

Abstract: Dette er siste tekst-versjon av artikkelen, og den kan inneholde ubetydelige forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du på bjsm.bmj.com: http://dx

Cited by 241 publications

References 89 publications

The Role of Platelet-Rich Plasma in Inducing Musculoskeletal Tissue Healing

The Role of Platelet-Rich Plasma in Inducing Musculoskeletal Tissue Healing

Platelet-rich plasma for muscle injuries: game over or time out?

Biomechanical study of the effect of platelet rich plasma on the treatment of medial collateral ligament lesion in rabbits

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