Iodide Ion-Promoted Highly Regioselective Triazolization of Aldehydes via Desulfonation-Associated Direct Radical Coupling

Abstract

A highly efficient iodide ion (I − )-promoted method for direct α-C(sp 2 )−H triazolization of aldehydes has been developed for the regioselective synthesis of N 2 -substituted triazole derivatives. The developed method features the corresponding products in good yields (up to 99%) with an excellent functional group tolerance via an intermolecular oxidative radical coupling. Experimental mechanistic investigations indicate that the reaction proceeds via an I − -promoted synergistic desulfonylation process, which provides a high regioselectivity. The developed method provides a direct, metal-free, operationally simple, and highly regioselective approach to C(sp 2 )−H triazolization from easily accessible aldehydes in air.