Iodide Repletion Test in an Endemic Goitre Area

Ek, B.; Johnsson, S; Porat, Bertil von

doi:10.1111/j.0954-6820.1963.tb17414.x

Cited by 23 publications

(6 citation statements)

References 4 publications

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“…The uptake is greater than normal in hyperthyroidism, but this was excluded in all these patients. It is also increased in states of iodine deficiency (3,19). The results presented here, which show an increased iodide uptake by the thyroid and diminished urinary iodine excretion, are consistent with an increased prevalence of iodine depletion.…”

Section: Discussionsupporting

confidence: 86%

The Thyroid in Ulcerative Colitis and Crohn's Disease

Järnerot

1975

Journal of Internal Medicine

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In order to investigate the prevalence of iodine depletion in chronic inflammatory bowel disease two separate studies have been performed. One was devoted to the 24‐hour urinary iodine excretion and 50 patients with ulcerative colitis or Crohn's disease were examined and compared with 102 controls. In the other study the thyroid 131I uptake was compared in 38 patients and 36 controls. Ten of the 50 patients with chronic inflammatory bowel disease had a 24‐hour urinary iodine excretion less than 40 μ.g, compared with 5 of the 102 controls (p < 0.01). Sixteen of the 38 patients had a 24‐hour thyroid 131I uptake of 50% or more of the administered test dose, compared with 4 of the 36 controls (p < 0.01). These results are compatible with an increased occurrence of iodine deficiency in patients with chronic inflammatory bowel disease. Treatment with corticosteroids or Salazopyrin® or a milk‐free diet did not influence these findings. No evidence was found of an impaired absorption of inorganic iodide from the gut.

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Section: Discussionsupporting

confidence: 86%

The Thyroid in Ulcerative Colitis and Crohn's Disease

Järnerot

1975

Journal of Internal Medicine

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“…Normal value for PBI is 3.8-8 pg%. Determination of total plasma radio activity (total 131 1) and PB I311 were made with an apparatus supplied by Abbott & Co. Total 131 1 and PB I311 were measured in a wel1-counter with the same equipment as used for the tracer dose determinations (10). The total 131 1 sample was passed through an ion-exchange column (Ioresin Abbott or Dowex l-X8, 50-100 mesh) which removed the free 131 1, leaving the PB I311 in the sample (33).…”

Section: Resultsmentioning

confidence: 99%

“…Methods for tracer-dose test with 131I, protein-bound iodine (PBI) and basal metabolic rate (BMR) are given in a previous paper (10). Normal values for the 2-hour (Th 2 ) and 24-hour (Th 24 ) uptakes in the thyroid and for urine output in 24 hours (U 2l ) arc:…”

Section: Methodsmentioning

confidence: 99%

“…The introduction of the radioactive iodine test was a considerable advance in the diagnosis of thyroid dysfunction. It has been found, however, that radioiodine tests based on determination of thyroid uptake or urinary excretion frequently provide misleading information in endemic goitre areas (10). In these areas persons without any signs of hyperthyroidism often show a raised traceriodine uptake and a lowered traceriodine excretion, simulating hyperthyroidism.…”

mentioning

confidence: 99%

“…Even though endemic goitre may be caused by goitrogens (6), the most important factor is considered to be iodine deficiency (I, 10,18,28). In iodine deficiency one finds a low inorganic plasmaiodine level, yet as a rule a normal absolute iodine uptake in the thyroid (I).…”

mentioning

confidence: 99%

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