Iodine‐123 metaiodobenzylguanidine scintigraphic assessment of pulmonary vascular status in patients with chronic obstructive pulmonary disease

Koizumi, Tomonobu; Urushihata, Kazuhisa; Hanaoka, Masayuki; Tsushima, Kenji; Fujii, Tsuneo; Kubo, Keishi

doi:10.1111/j.1440-1843.2010.01853.x

Cited by 5 publications

(5 citation statements)

References 22 publications

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“…Biddiscombe et al compared different indices among different methods for defining regions and found that PI, defined as peripheral/central aerosol counts normalized by peripheral/central krypton ventilation counts, was less affected by the size of the peripheral and central regions among different methods 25 . Using I‐123 MIBG scintigraphy, Tomonobu et al found in patients with COPD the LMR (the total lung‐to‐upper mediastinum ratio) was not correlated with the pulmonary function parameters measured, including FEV 1 , PaO 2 , DL(CO) or pulmonary artery pressure at rest 26 …”

Section: Discussionmentioning

confidence: 99%

“…25 Using I-123 MIBG scintigraphy, Tomonobu et al found in patients with COPD the LMR (the total lung-to-upper mediastinum ratio) was not correlated with the pulmonary function parameters measured, including FEV 1 , PaO 2 , DL(CO) or pulmonary artery pressure at rest. 26 Theoretically, larger particles tend to deposit at larger lumen. In this study, Ga-68 EDTA aerosols distributed more in central region, with different patterns among the different groups.…”

Section: Discussionmentioning

confidence: 99%

“… 25 Using I‐123 MIBG scintigraphy, Tomonobu et al found in patients with COPD the LMR (the total lung‐to‐upper mediastinum ratio) was not correlated with the pulmonary function parameters measured, including FEV 1 , PaO 2 , DL(CO) or pulmonary artery pressure at rest. 26 …”

Section: Discussionmentioning

confidence: 99%

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Ga‐68 EDTA aerosols in evaluation of inhaled‐particle deposition and clearance of obstructive pulmonary diseases: A pilot prospective study compared with Galligas

Wang

Bao

Liu

et al. 2021

Eur J Clin Investigation

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Purpose: 68-gallium (Ga-68) ethylenediaminetetraacetic acid (EDTA) aerosols and Galligas were compared in evaluation of inhaled-particle deposition and clearance in volunteers with or without obstructive pulmonary diseases. Methods: Nonsmoking healthy volunteers, healthy smokers, asthma patients and patients with chronic obstructive pulmonary disease (COPD) were recruited to undergo the dynamic lung ventilation positron emission tomography/computerized tomography (PET/CT) scans within two consecutive days. The inhaled particles were Ga-68labelled carbon nanoparticles (Galligas, 30-60 nm in size) and Ga-68-labelled EDTA aerosols (1-2 μm in size), respectively. The volunteers' lung function parameters were measured for comparison. Results: Central deposition and inhomogeneity of both tracers were negatively correlated with lung function parameters, including the ratio of forced expiratory volume at 1 second to forced vital capacity (FEV 1 /FVC). The central or hilum deposition of Galligas, but not 68-gallium (Ga-68) EDTA, was negatively correlated with the maximal expiratory flow at 25%, 50% and 75% of the forced vital capacity. Compared with Galligas, Ga-68 EDTA aerosols were more concentrated in the central region in all groups except for the healthy nonsmokers. Ventilation inhomogeneity was more evident when using Ga-68 EDTA aerosols, especially in patients with COPD and asthma patients. In the healthy smokers, the central region accumulated more Ga-68 EDTA at 30 minutes after inhalation than immediately after inhalation. Ga-68 EDTA cleared faster in lungs than Galligas.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ga‐68 EDTA aerosols in evaluation of inhaled‐particle deposition and clearance of obstructive pulmonary diseases: A pilot prospective study compared with Galligas

Wang

Bao

Liu

et al. 2021

Eur J Clin Investigation

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“…Decreased lung uptake of 123I‐MIBG has been demonstrated in patients with COPD as compared with normal subjects. Koizumi and colleagues demonstrated that early lung uptake of 123I‐ MIBG is inversely correlated with increased pulmonary artery pressure during exercise in patients with COPD 38 …”

Section: Clinical Copdmentioning

confidence: 99%

Year‐in‐review 2010: Asthma, COPD, cystic fibrosis and airway biology

et al. 2011

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“…МИБГ представляет собой аналог норадреналина, что позволяет наблюдать проявления симпатической денервации миокарда ЛЖ, имеющие известное прогностическое значение у пациентов с хронической сердечной недостаточностью [26,27]. Есть данные о возможности оценки накопления МИБГ в легких, которое снижено у пациентов с ХОБЛ по сравнению с группой нормы [28]. Аналогичных исследований ПЖ, в частности у пациентов с ЛГ, выполнено крайне мало.…”

Section: Introductionunclassified

Myocardial Perfusion and Neurotropic Single-Photon Emission Computed Tomography Features in Patients With Primary Pulmonary Hypertension

Аншелес

Kuznetsova

Martynyuk

et al. 2018

Vestn. rentgenol. radiol.

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Objective.To compare cardiac123I-MIBG and99m Tc-MIBI single-photon emission computed tomography (SPECT) data in patients with primary pulmonary hypertension (PPH).Material and methods.The study included 22 patients with confirmed diagnosis of PPH, with clinical status assessment, Holter ECG monitoring and rest cardiac ultrasound (US) data. All patients, as well as a group of healthy volunteers (n=20) underwent myocardial perfusion SPECT with99mTc-MIBI at rest and after treadmill exercise test, and myocardial neurotropic SPECT with123I-MIBG, performed in 15 min (early phase) and 4 hours (delayed phase) after MIBG administration. LV perfusion abnormalities were evaluated using standard SSS and SDS parameters, RV was assessed visually, RV/LV and IVS/LW uptake ratios were calculated. Global sympathetic activity (SA) was assessed with delayed heart/mediastinum ratio (H/Md) and MIBG Washout Rate in 4 hours (WR). Regional SA abnormalities were assessed using early Summed MIBG Score (SMSe). MIBG RV/LV and LV IVS/LW uptake ratios were calculated. All parameters were compared with normal database (n=20).Results.The values of a number of myocardial SPECT parameters, both perfusion (SSS, RV/LVMIBI, IVS/LWMIBI) and neurotropic (H/Md, WR, SMSe, IVS/LWMIBG), were significantly worse in PPH patients compared to the control group (all p<0.05). Perfusion SPECT showed no significant (SDS>4) transient LV ischemia in all patients, but in 77% of cases IVS perfusion was stably impaired, causing overall SSS=7 (6–10), presumably due to IVS compression by dilated RV. MIBI RV/LV ratio was 0.61±0.02, indicating that RV was clearly visible, with inhomogeneous MIBI uptake in all cases, but without reliable perfusion defects. Values of H/Mdwere 1.84±0.18, WR: 27±8%, with no reliable correlations with perfusion parameters. Regional SA defects also were located in IVS predominately, causing SMSemean value of 8 (6–10) and IVS/LW of 0.69±0.09, both parameters correlated with SSS (r=0.44, p=0.04 and r=-0.48, p=0.02, respectively). All parameters, except RV/LVMIBG, had reliable correlations with systolic pulmonary artery pressure assessed by cardiac US, especially RV/LVMIBI(r=0.64, p<0.01), WR (r=0.55, p=0.01) and IVS/LWMIBG(r=-0.49, p=0.02).Conclusion.Combination of myocardial neurotropic and perfusion SPECT has a certain diagnostic value in patients with PPH, since MIBG SPECT reflects SA downregulating, and MIBI SPECT reveals specific microcirculatory abnormalities in these patients, both possibly caused by myocardial pressure overload and responsible for angina-like symptoms.

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Iodine‐123 metaiodobenzylguanidine scintigraphic assessment of pulmonary vascular status in patients with chronic obstructive pulmonary disease

Cited by 5 publications

References 22 publications

Ga‐68 EDTA aerosols in evaluation of inhaled‐particle deposition and clearance of obstructive pulmonary diseases: A pilot prospective study compared with Galligas

Ga‐68 EDTA aerosols in evaluation of inhaled‐particle deposition and clearance of obstructive pulmonary diseases: A pilot prospective study compared with Galligas

Year‐in‐review 2010: Asthma, COPD, cystic fibrosis and airway biology

Myocardial Perfusion and Neurotropic Single-Photon Emission Computed Tomography Features in Patients With Primary Pulmonary Hypertension

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