The incidence of bedsores varies from 3 to 40%, with a maximum of 80% in patients in critical condition for a long time. Purpose: analysis of effective methods of therapy and prevention of bedsores. Object and methods of research. Thirty-one scientific publications from PubMed, Scopus databases since 2020 were analyzed. The analyzed methods included vacuum therapy, ultrasound methods, hydrosurgery, plasma flow method, laser application, electrostimulation, and a complex combination of methods. Results. Many involved methods give the choice in therapy strategy. The most expedient and effective is the complex combination of methods. Conclusion. Currently, a decrease in the incidence of bedsores is not expected; therefore, the analysis of the effectiveness of methods of therapy and prevention of bedsores remains relevant.