Iodine deficiency increases apoptosis and decreases synaptotagmin-1 and PSD-95 in rat hippocampus

Dong, Jing; Wang, Yuan; Wang, Yi; Wei, Wei; Min, Hui; Song, Binbin; Xi, Qi; Wang, Teng; Chen, Jie

doi:10.1179/1476830512y.0000000040

Cited by 6 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reduced expression level in the brain of hypothyroid rodents and the accumulation of mRNA stimulated by THs have been demonstrated for myelin‐associated glycoprotein (Rodriguez‐Peña et al, ), myelin basic protein (Ibarrola & Rodríguez‐Peña, ), Na + ,K + ‐ATPase α2 (Chaudhury, Bajpai, & Bhattacharya, ) and neurofilament light and medium genes (Ghosh, Rahaman, & Sarkar, ). Expression levels of astroglial K + channel and PSD‐95 mRNAs are decreased in hypothyroid animals (Dong et al, ; Gil‐Ibañez, Morte, & Bernal, ). Furthermore, the functional TH response element is in the promoter of the mouse myelin basic protein and myelin‐associated glycoprotein genes (Dong et al, ; Farsetti, Desvergne, Hallenbeck, Robbins, & Nikodem, ).…”

Section: Discussionmentioning

confidence: 99%

Developmental gene expression patterns in the brain and liver of Xenopus tropicalis during metamorphosis climax

Yaoita

Nakajima

2018

Genes to Cells

View full text Add to dashboard Cite

Thyroid hormones (THs) induce metamorphosis in amphibians, causing dynamic changes, whereas mammalian newborns undergo environmental transition from placenta to open air at birth. The similarity between amphibian metamorphosis and the mammalian perinatal periods has been repeatedly discussed. However, a corresponding developmental gene expression analysis has not yet been reported. In this study, we examined the developmental gene expression profiles in the brain and liver of Xenopus tropicalis during metamorphosis climax and compared them to the respective gene expression profiles of newborn rodents. Many upregulated genes identified in the tadpole brain during metamorphosis are also upregulated in the rodent brain during the first three postnatal weeks when the TH surge occurs. The upregulation of some genes in the brain was inhibited in thyroid hormone receptor α (TRα) knockout tadpoles but not in TRβ–knockout tadpoles, implying that brain metamorphosis is mainly mediated by TRα. The expression of some genes was also increased in the liver during metamorphosis climax. Our data suggest that the rodent brain undergoes TH‐dependent remodeling during the first three postnatal weeks as observed in X. tropicalis during the larva‐to‐adult metamorphosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Developmental gene expression patterns in the brain and liver of Xenopus tropicalis during metamorphosis climax

Yaoita

Nakajima

2018

Genes to Cells

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated that thyroid dysfunction affected synaptic proteins in adult rats [26]. Thyroid hormone deficiency resulted in the down-regulation of syt-1 expression in rat hippocampus [25,27] and cerebellum [28], and the impairment in hippocampal-dependent tasks of learning and memory [29]. These findings emphasized a close relationship between thyroid dysfunction and syt-1.…”

Section: Animal Model Of Schmentioning

confidence: 62%

Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization

et al. 2015

Endocr J

View full text Add to dashboard Cite

“…A number of apoptotic genes are regulated by TH . It is possible that neurones normally present in the foetal corpus callosum remain in the absence of TH‐dependent signals activating programmed cell death.…”

Section: Discussionmentioning

confidence: 99%

Subcortical Band Heterotopia in Rat Offspring Following Maternal Hypothyroxinaemia: Structural and Functional Characteristics

Gilbert

Ramos

McCloskey

et al. 2014

J Neuroendocrinology

View full text Add to dashboard Cite

Thyroid hormones (TH) play crucial roles in brain maturation and are important for neuronal migration and neocortical lamination. Subcortical band heterotopia (SBH) represent a class of neuronal migration errors in humans that are often associated with childhood epilepsy. We have previously reported the presence of SBH in a rodent model of low level hypothyroidism induced by maternal exposure to the goitrogen, propylthiouracil (PTU). In the present study, we report the dose-response characteristics of this developmental malformation and the connectivity of heterotopic neurones with other brain regions, as well as their functionality. Pregnant rats were exposed to varying concentrations of PTU through the drinking water (0-10 p.p.m.) beginning on gestational day 6 to produce graded levels of TH insufficiency. Dose-dependent increases in the volume of the SBH present in the corpus callosum were documented in the adult offspring, with a clear presence at concentrations of PTU that resulted in minor (< 15%) reductions in maternal serum thyroxine as measured when pups were weaned. SBH contain neurones, oligodendrocytes, astrocytes and microglia. Monoaminergic and cholinergic processes were prevalent and many of the axons were myelinated. Anatomical connectivity of SBH neurones to cortical neurones and the synaptic functionality of these anatomical connections was verified by ex vivo field potential recordings. SBH persisted in adult offspring despite a return to euthyroid status on termination of exposure and these offspring displayed an increased sensitivity to seizures. Features of this model are attractive with respect to the investigation of the molecular mechanisms of cortical development, the effectiveness of therapeutic intervention in hypothyroxinaemia during pregnancy and the impact of the very modest TH imbalance that accompanies exposure to environmental contaminants.

show abstract

Iodine deficiency increases apoptosis and decreases synaptotagmin-1 and PSD-95 in rat hippocampus

Abstract: Developmental ID resulted in the increase and delay of cell apoptosis and the decrease of synaptotagmin-1 and PSD-95 in the hippocampus, which were implicated in the impairment of brain development.

Cited by 6 publications

References 40 publications

Developmental gene expression patterns in the brain and liver of Xenopus tropicalis during metamorphosis climax

Developmental gene expression patterns in the brain and liver of Xenopus tropicalis during metamorphosis climax

Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization

Subcortical Band Heterotopia in Rat Offspring Following Maternal Hypothyroxinaemia: Structural and Functional Characteristics

Contact Info

Product

Resources

About