Iodine‐loaded poly(silicic acid) gellan nanocomposite mucoadhesive film for antibacterial application

Abstract

Iodine‐loaded poly(silicic acid) gellan nanocomposite film was fabricated and evaluated for antibacterial properties. Poly(silicic acid) nanoparticles were synthesized by condensation of silicic acid under alkaline conditions in the presence of polyvinyl pyrrolidone, phosphate ions, and molecular iodine. The nanoparticles were incorporated into gellan dispersion to prepare gellan nanocomposite film using the solvent casting method. The nanocomposite films were characterized by Fourier transformed infrared spectroscopy, thermogravimetric analysis, and X‐ray diffraction studies. The results of characterization studies indicated improved thermal stability and an increase in the degree of crystallinity. The scanning electron micrographs and energy dispersive X‐ray spectrum confirmed the uniform dispersion of silica and iodine in the nanocomposite films. The analysis of physical and mechanical properties revealed the enhanced tensile strength, moisture resistance, and higher folding endurance of poly(silicic acid) gellan nanocomposite films as compared to gellan film. Further, the iodine‐loaded poly(silicic acid) gellan nanocomposite films showed good antibacterial activity against Staphylococcus aureus and Escherichia coli and effective mucoadhesive strength. The results indicate that iodine‐loaded poly(silicic acid) gellan nanocomposite mucoadhesive film can be used for potential antibacterial applications in pharmaceuticals.

Effect of black wolfberry anthocyanin and maltitol on the gelation and microstructural properties of curdlan/gellan gum hybrid gels

“…In the FTIR spectrum of CG composite gel, the characteristic peaks of CG were observed at 3285 cm −1 (O-H stretching), 2915 cm −1 (C-H stretching), 1605 cm −1 (carboxyl group), and 1405 cm −1 (C-C vibration bond). 37 The hydroxyl stretching vibration peaks of CG reflected redshifts to 3388-3399 cm −1 after BWA addition at different concentrations of 5, 10, and 15 g L −1 , indicating the involvement of hydrogen bonds in the interactions of CG and BWA. As reported, comparing spectrum of ⊎-glucan, konjac glucomannan and xanthan gum, the formed anthocyanins/polysaccharides complexes, shown by the blueshift of O-H stretching, indicating the hydrogen bonds involvement between these polysaccharides and anthocyanins.…”

“…Moreover, the absorption peaks of CG at 2916 cm −1 (C-H stretching) and 1405 cm −1 (C-C vibration bond) moved to higher wavenumbers with the addition of BWA or ML, probably due to chemical modifications. 37 Therefore, the improvement of CG gel performance with BWA or ML addition is mainly due to hydrogen bond participation and chemical structural changes, leading to an ordered structure. Effect of BWA and ML on the microstructure of CG complex Three-dimensional network structure plays a key role in determining the functional properties of hydrogels.…”

“…Figure 3 compares the spectra of CG, CG‐BWA and CG‐ML. In the FTIR spectrum of CG composite gel, the characteristic peaks of CG were observed at 3285 cm −1 (O–H stretching), 2915 cm −1 (C–H stretching), 1605 cm −1 (carboxyl group), and 1405 cm −1 (C–C vibration bond) 37 . The hydroxyl stretching vibration peaks of CG reflected redshifts to 3388–3399 cm −1 after BWA addition at different concentrations of 5, 10, and 15 g L −1 , indicating the involvement of hydrogen bonds in the interactions of CG and BWA.…”

Preparation of Salbutamol Sulphate Loaded Locust Bean Gum-Polyvinyl Alcohol Composite Cryogel for Drug Delivery

“…X-ray diffraction is a technique that is widely used to explore the nature of the polymer that whether it is crystalline or amorphous in nature. This technique is carried out to investigate the possible change in crystalline structure behaviour [47]. However, diffraction pattern of LBG-PVA composite cryogel indicating characteristic peak at 19.83° (2θ) which suggest that formation of cryogels between two polymers contributes to a decrease in crystallinity [9].…”

Optimization and Characterization of a Novel Antioxidant Naringenin-Loaded Hydrogel for Encouraging Re-Epithelization in Chronic Diabetic Wounds: A Preclinical Study

“…The 3D response surface and related 2D contour plots for the influence of each chosen CMA are shown in Figures 1a−f and 2a−f, viz., Na-alginate, PVA, and pluronic F-127 on studied CQAs like mechanical strength and swelling (%) of the prepared hydrogel. Figures 1a,c,e and 2a,c,e illustrate the curvilinear 3D response surface plots representing the response surface plots for mechanical strength and swelling (%), while the corresponding 2D contour plots represent the analogous information, 20,21 as depicted in Figures 1b,d,f and 2b,d,f. Mechanical Strength.…”