Iodine nutrition in ewes. 2. Effects of low to high iodine intake by ewes on the I content of biological fluids and plasma immunoglobulins G in newborn lambs

Aumont, Gilles; Levieux, Didier; Lamand, M.; Tressol, J.C.

doi:10.1051/rnd:19890208

Cited by 7 publications

(3 citation statements)

References 20 publications

(31 reference statements)

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“…It has long been recognised that increasing the supply of I to farm livestock increases the circulating concentrations of thyroid hormones (Aumont et al 1989 a , b ). In the pregnant rat, subcutaneous T4 injections immediately prepartum have been shown to reduce the intestinal permeability to macromolecules in the postpartum period (Chan et al 1973).…”

Section: Discussionmentioning

confidence: 99%

Effect of the level of iodine in the diet of pregnant ewes on the concentration of immunoglobulin G in the plasma of neonatal lambs following the consumption of colostrum

2007

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Excessive I in the diet of pregnant sheep can reduce the concentration of antibodies in the blood plasma of the lambs after they have consumed colostrum. Our aim was to determine the dose of dietary I that would avoid this effect, and to relate this to changes in the concentrations of hormones and metabolites in the lambs. Four groups of pregnant ewes received concentrate containing 5·5, 9·9, 14·8, and 21·0 mg I/kg DM, respectively. Hay and molasses (containing 0·16 and 0·29 mg I/kg DM, respectively) were available ad libitum. The lambs were prevented from suckling for the first 24 h of life and were fed a fixed quantity of artificial colostrum in four feeds. At 24 h, the average plasma concentrations of immunoglobulin G in the lambs were 6·08, 5·06, 3·18 and 3·10 g/l for the 5·5, 9·9, 14·8 and 21·0 mg/kg groups, respectively. Supplementation with I was associated with higher levels of tri-iodothyronine and thyroxine in the lambs at birth. There was no effect of treatment on the plasma concentrations of insulin, cortisol, glucose or NEFA in the lambs. The concentration of dietary I that had an effect on the immunoglobulin concentration in the lambs is marginally above the levels added to commercial concentrate feeds; we tentatively identify 9·9 mg I/kg DM (approximately 9 mg I/ ewe per day) as the upper safe limit of I supplementation according to the criterion of the concentration of immunoglobulin G in the plasma of lambs at 24 h after birth.

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Section: Discussionmentioning

confidence: 99%

Effect of the level of iodine in the diet of pregnant ewes on the concentration of immunoglobulin G in the plasma of neonatal lambs following the consumption of colostrum

2007

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“…The mean concentrations of plasma inorganic iodine in the deficient heifers remained very low (approximately 10 μg/litre) throughout the experimental period, whereas in the sufficient heifers they plateaued at approximately 55 to 60 μg/litre. Aumont and others (1989) recorded plasma inorganic iodine concentrations of approximately 70 μg/litre in pregnant sheep fed a diet with an iodine concentration of 2·01 mg/kg dm . McCoy and others (1995) suggested that the lower normal limit for plasma inorganic iodine concentrations in pregnant cattle was 80 μg/litre.…”

Section: Methodsmentioning

confidence: 99%

Experimental reproduction of iodine deficiency in cattle

McCoy¹,

Smyth²,

Ellis³

et al. 1997

Veterinary Record

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The role of iodine deficiency in stillbirth/perinatal weak calf syndrome was investigated in pregnant heifers. Five heifers were fed an iodine deficient diet (mean [sd] iodine concentration 0.06 [0.01] mg/kg dry matter [DM]) and six received an iodine sufficient diet (mean [sd] iodine concentration 1.45 [0.27] mg/kg DM). The diets consisted of wheat and soyabean meal with added minerals and vitamins (with or without iodine) and were fed to the heifers over the final four to five months of pregnancy. The iodine deficient diet produced clinicopathological changes and pathological changes in the thyroid glands of both the heifers and their offspring. However, all the calves in the iodine deficient group were born clinically normal.

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“…Except these two studies (Singh et al, 1994;Šlosárková et al, 1999), no other literature about the relation between iodine supplementation and clinical signs of toxoplasmosis was available. We know, that iodine deficiency influences immune system negatively (Jones et al, 1986;Aumont et al, 1989) and that host's immune response has crucial impact on progress of toxoplasmosis (Denkers and Gazzinelli, 1998).…”

mentioning

confidence: 99%

Experimental toxoplasmosis in hypoiodemic mice

Šlosárková¹,

Hřı́balová²,

Literák³

et al. 2002

Vet. Med. - Czech

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ABSTRACT:The hypothesis, that hypoiodemia of goats causes such a compromise of the immune system, which during subsequent Toxoplasma gondii infections results in clinically more pronounced signs of toxoplasmosis, was verifying in laboratory mouse. Hypoiodemic mice (fed by wheat and supplied by water), normoiodemic mice (fed by wheat and supplied by water containing 1.25 mg KI/l) and the majority of standard mice (fed by commercial grain mixture containing 0.83 mg I/kg) were experimentally infected with T. gondii oocysts or tachyzoites. The susceptibility to acute T. gondii infection was evaluated according to mortality rate. As a criterion of cell-mediated immune function has been chosen the spleen-lymphocyte transformation test (LTT). We observed no difference in LTT between hypoiodemic and normoiodemic mice infected with T. gondii oocysts or tachyzoites and no difference in mortality of both infected groups. Four days after the exposure to 100 tachyzoites of T. gondii (K24 strain), all experimentally infected groups of mice showed statistically significant decrease (P = 0.004) in spleen cells responsiveness to stimulation by all mitogens used -as compared to non-infected standard mice group. Reduced responsiveness of cells was probably caused by T. gondii infection itself -the relation to iodine deficiency has not been found.

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Iodine nutrition in ewes. 2. Effects of low to high iodine intake by ewes on the I content of biological fluids and plasma immunoglobulins G in newborn lambs

Cited by 7 publications

References 20 publications

Effect of the level of iodine in the diet of pregnant ewes on the concentration of immunoglobulin G in the plasma of neonatal lambs following the consumption of colostrum

Effect of the level of iodine in the diet of pregnant ewes on the concentration of immunoglobulin G in the plasma of neonatal lambs following the consumption of colostrum

Experimental reproduction of iodine deficiency in cattle

Experimental toxoplasmosis in hypoiodemic mice

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