2024
DOI: 10.1039/d4ob01146e
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Iodine-promoted sequential C(sp3)–H oxidation and cyclization of aryl methyl ketones with 2-(2-aminophenyl)quinazolin-4(3H)-ones

Mariyaraj Arockiaraj,
Venkatachalam Rajeshkumar

Abstract: I2-promoted, metal-free protocol has been developed for the one-pot synthesis of 6-aroyl-5,6-dihydro-8H-quinazolino[4,3-b]quinazolin-8-ones from readily accessible substrates. This reaction involves in situ sp3 C-H oxidation of aryl methyl ketones to phenylglyoxal,...

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