Iodine(iii)-mediated dehydroaromatization of cyclohexanones with primary amines and CD₃SSO₃Na to access ortho-SCD₃ anilines

Abstract

Iodine (III)-mediated dehydroaromatization of cyclohexanones with primary amines and CD3SSO3Na has been developed, providing direct access ortho-SCD3 anilines with the formation of C-N and C-S bonds. Detailed mechanism studies indicates...

Regioselective C3Alkylation of Indoles for the Synthesis of Bis(indolyl)methanes and 3-Styryl Indoles

“…Recently, we reported a nitrobenzene-involved oxidative reaction for the synthesis of N-heterocycles . In continuation of our interest in constructing complex N-heterocycles from easily accessible substrates, we attempted a reaction of indoles with alcohols that were oxidized by nitrobenzene under strong basic conditions. Interestingly, C 3 rather than N 1 of indoles were functionalized to give corresponding bis­(indolyl)­methanes and 3-styryl indoles.…”

Aminothiolation of alkenes with azoles and Bunte salts

“…They have gained popularity due to their ease of preparation and handling. Traditionally, it is frequently used in transition-metal catalyzed cross-coupling reactions (Qiao et al, 2015;Liu and Yi, 2018;Wang et al, 2023;Wu et al, 2023). However, these methods require a toxic transitionmetal catalyst, which not only limits the range of substrates but also generates a significant amount of environmentally unfriendly byproducts.…”

Electrochemical aminotrideuteromethylthiolation of isocyanides with anilines and CD3SSO3Na

“…10 However, achieving the aminotrideuteromethylthiolation of a single carbon atom remains elusive. Based on our continuous studies on Bunte salts, 11 herein, we describe an unprecedented electrochemically-induced strategy enabling a three-component radical reaction between isocyanides, anilines and CD 3 SSO 3 Na to afford S -CD 3 isothiourea in a single step (Scheme 1C).…”