Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study

Zimmermann, Michael; Connolly, Kevin; Bozo, Maksim; Bridson, John; Rohner, Fabian; Grimci, Lindita

doi:10.1093/ajcn/83.1.108

Cited by 190 publications

(174 citation statements)

References 31 publications

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“…More recent iodine supplementation trials from Albania and New Zealand found that supplementation of mildly iodine deficient 10-13 years old children improved matrix reasoning in both studies. In addition, fine motor skills and visual problem solving were improved in the Albanian trial (Zimmermann, 2006;Gordon et al, 2009). Relatively few studies have been conducted in very young children to support the significance of iodine in cognitive development (Melse-Boonstra and Jaiswal, 2010).…”

Section: Iodinementioning

confidence: 97%

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Nyaradi¹,

Li²,

Hickling³

et al. 2015

Prenatal and Childhood Nutrition

129

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This review examines the current evidence for a possible connection between nutritional intake (including micronutrients and whole diet) and neurocognitive development in childhood. Earlier studies which have investigated the association between nutrition and cognitive development have focused on individual micronutrients, including omega-3 fatty acids, vitamin B12, folic acid, choline, iron, iodine, and zinc, and single aspects of diet. The research evidence from observational studies suggests that micronutrients may play an important role in the cognitive development of children. However, the results of intervention trials utilizing single micronutrients are inconclusive. More generally, there is evidence that malnutrition can impair cognitive development, whilst breastfeeding appears to be beneficial for cognition. Eating breakfast is also beneficial for cognition. In contrast, there is currently inconclusive evidence regarding the association between obesity and cognition. Since individuals consume combinations of foods, more recently researchers have become interested in the cognitive impact of diet as a composite measure. Only a few studies to date have investigated the associations between dietary patterns and cognitive development. In future research, more well designed intervention trials are needed, with special consideration given to the interactive effects of nutrients.

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Section: Iodinementioning

confidence: 97%

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Nyaradi¹,

Li²,

Hickling³

et al. 2015

Prenatal and Childhood Nutrition

129

View full text Add to dashboard Cite

show abstract

“…It was found that compared with placebo iodine treatment improves performance on tests of information processing, fine motor skills and visual problem solving (38) . These findings have recently been confirmed in mildly-iodinedeficient New Zealand children (39) .…”

Section: Childhoodmentioning

confidence: 99%

Symposium on ‘Geographical and geological influences on nutrition’ Iodine deficiency in industrialised countries

Zimmermann

2009

Proc. Nutr. Soc.

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Iodine deficiency is not only a problem in developing regions; it also affects many industrialised countries. Globally, two billion individuals have an insufficient iodine intake, and approximately 50% of continental Europe remains mildly iodine deficient. Iodine intakes in other industrialised countries, including the USA and Australia, have fallen in recent years. Iodine deficiency has reappeared in Australia, as a result of declining iodine residues in milk products because of decreased iodophor use by the dairy industry. In the USA, although the general population is iodine sufficient, it is uncertain whether iodine intakes are adequate in pregnancy, which has led to calls for iodine supplementation. The few available data suggest that pregnant women in the Republic of Ireland and the UK are now mildly iodine deficient, possibly as a result of reduced use of iodophors by the dairy industry, as observed in Australia. Representative data on iodine status in children and pregnant women in the UK are urgently needed to inform health policy. In most industrialised countries the best strategy to control iodine deficiency is carefully-monitored salt iodisation. However, because approximately 90% of salt consumption in industrialised countries is from purchased processed foods, the iodisation of household salt only will not supply adequate iodine. Thus, in order to successfully control iodine deficiency in industrialised countries it is critical that the food industry use iodised salt. The current push to reduce salt consumption to prevent chronic diseases and the policy of salt iodisation to eliminate iodine deficiency do not conflict; iodisation methods can fortify salt to provide recommended iodine intakes even ifper capitasalt intakes are reduced to <5 g/d.

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“…Impaired production of thyroid hormones during pregnancy affects growth and brain development in the progeny (Glinoer, 2007;Morreale de Escobar et al, 2007;Zimmermann, 2007). Iodine deficiency in school-age children impairs somatic growth, cognitive performance and motor function (Zimmermann et al, 2006;Zimmermann et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Adequate iodine nutrition in Sweden: a cross-sectional national study of urinary iodine concentration in school-age children

et al. 2008

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Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study

Abstract: Information processing, fine motor skills, and visual problem solving are improved by iodine repletion in moderately iodine-deficient schoolchildren.

Cited by 190 publications

References 31 publications

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Symposium on ‘Geographical and geological influences on nutrition’ Iodine deficiency in industrialised countries

Adequate iodine nutrition in Sweden: a cross-sectional national study of urinary iodine concentration in school-age children

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