Iododerma after computed tomographic scan with intravenous radiopaque contrast media

Chang, Mary Wu; Miner, John E.; Moiin, Ali; Hashimoto, Ken

doi:10.1016/s0190-9622(97)80291-5

Cited by 30 publications

(27 citation statements)

References 9 publications

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“…Generalized cases have been reported 1 . Other variants include vesicular, urticarial, hemorrhagic, ulcerative, vegetative and nodular lesions 2 . Iododerma has been found to occur days to years after iodide exposure.…”

Section: Introductionmentioning

confidence: 99%

Use of topical povidone‐iodine resulting in an iododerma‐like eruption

Massé

Falanga

Zhou

2008

The Journal of Dermatology

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Iododerma is a rare skin eruption that is usually induced by the systemic use of iodide-containing radiographic contrast medium or treatment with oral potassium iodide therapy. Iododerma has also rarely been reported to occur following topical application of iodine. We herein report the case of a 42-year-old male who developed multiple pinpoint pustules on both lower extremities. Three days after the eruption began, the patient started applying topical 10% povidone-iodine solution to the lesions. During this treatment, the lesions enlarged into multiple 2-9-cm pus-filled bullae, limited to the treated areas. Lesional bacterial culture swab and Gram stain were negative. Blood cultures were also negative and the patient's white blood cell count was normal. A punch biopsy specimen revealed pseudoepitheliomatous hyperplasia and dermal-epidermal separation with epidermal necrosis and underlying abscess formation. A superficial and deep perivascular, interstitial and perifollicular infiltrate containing numerous neutrophils, with abscess formation and eosinophils was also seen. This histology was consistent with iododerma and the patient's lesions involuted following cessation of topical iodine use, leaving only post-inflammatory hyperpigmentation. In summary, our patient likely had a folliculitis that was then treated with topical povidone-iodine that led to iododerma. Although it remains possible that the reaction was an unusual contact hypersensitivity response, the ulceration, pseudoepitheliomatous hyperplasia and abscess formation do support an iododerma-like eruption.

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Section: Introductionmentioning

confidence: 99%

Use of topical povidone‐iodine resulting in an iododerma‐like eruption

Massé

Falanga

Zhou

2008

The Journal of Dermatology

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“…2 Although usually self-limited, iododerma has been fatal and may cause considerable disfigurement. 3 The diagnosis of iododerma is dependent on the clinical evaluation and exposure history because there is no pathognomonic laboratory or histopathologic finding 4 ; however, elevated blood iodine levels and histologic findings may be useful in making the diagnosis. Histologically, a neutrophilic infiltrate in the dermis with exocytosis and intraepidermal abscess formation is most commonly observed; papillomatosis may be seen in longstanding lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Two cases of iododerma have been reported in response to intravenous diatrizoate contrast, both in the setting of renal insufficiency. 4 While systemic absorption through the gastrointestinal tract of this commonly used oral agent is minimal, excretory urograms have been reported to show renal clearance of systemically absorbed contrast material. 6 Our case demonstrates that iododerma may occur after a single dose of oral diatrizoate contrast, with risk of eruption enhanced by the patient's delayed renal clearance.…”

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confidence: 99%

Vegetative Plaques and Hemorrhagic Pustules

et al. 2013

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“…Despite iodinated CM being frequently used worldwide, iododerma is rarely observed in concert with iodinated CM injection. Only a few case reports have been published [65][66][67][68][69][70]. One death has been reported [68].…”

Section: Iododerma (Delayed)mentioning

confidence: 99%

A practical guide to diagnose lesser-known immediate and delayed contrast media-induced adverse cutaneous reactions

Böhm

Schild

2006

Eur Radiol

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The terms "immediate" and "delayed" adverse reactions induced by contrast media (CM) refer to the reactions' onset but do not provide substantial information concerning the clinical manifestation, the potential risk factors, the treatment modalities, or prevention. Because a variety of different reactions caused by different pathophysiological mechanisms may arise immediately or be delayed after CM injection, and because these need different management, the aim of the present paper is to present the clinical features and to exactly characterize lesser-known cutaneous reactions. A thorough knowledge of the clinical features, their adequate treatment, and, possibly, the subsequent diagnostic procedure for preventing recurrence after reexposure to CM would improve patient management.

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Iododerma after computed tomographic scan with intravenous radiopaque contrast media

Cited by 30 publications

References 9 publications

Use of topical povidone‐iodine resulting in an iododerma‐like eruption

Use of topical povidone‐iodine resulting in an iododerma‐like eruption

Vegetative Plaques and Hemorrhagic Pustules

A practical guide to diagnose lesser-known immediate and delayed contrast media-induced adverse cutaneous reactions

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