Iodophenol blue-enhanced luminol chemiluminescence and its application to hydrogen peroxide and glucose detection

Yu, Dalong; Wang, Ping; Zhao, Yanjun; Fan, Aiping

doi:10.1016/j.talanta.2015.06.059

Cited by 55 publications

(25 citation statements)

References 35 publications

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“…However, the difficulty of detecting H 2 O 2 has been an obstacle in investigating its involvement in health and disease. Over the past few decades, a myriad of methods for analytical quantification of H 2 O 2 have been developed, based on mass spectrometry [3], fluorescence [4], and chemiluminescence [5]. In addition, electrochemical sensors have been developed for the determination of H 2 O 2 .…”

Section: Introductionmentioning

confidence: 99%

A nanocomposite-based electrochemical sensor for non-enzymatic detection of hydrogen peroxide

Chen

Dong

et al. 2017

Oncotarget

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Hydrogen peroxide (H2O2) plays important signaling roles in normal physiology and disease. However, analyzing the actions of H2O2 is often impeded by the difficulty in detecting this molecule. Herein, we report a novel nanocomposite-based electrochemical sensor for non-enzymatic detection of H2O2. Graphene oxide (GO) was selected as the dopant for the synthesis of polyaniline (PANI), leading to the successful fabrication of a water-soluble and stable GO-PANI composite. GO-PANI was subsequently subject to cyclic voltammetry to generate reduced GO-PANI (rGO-PANI), enhancing the conductivity of the material. Platinum nanoparticles (PtNPs) were then electrodeposited on the surface of the rGO-PANI-modified glassy carbon electrode (GCE) to form an electrochemical H2O2 sensor. Compared to previously reported sensors, the rGO-PANI-PtNP/GCE exhibited an expanded linear range, higher sensitivity, and lower detection limit in the quantification of H2O2. In addition, the sensor displayed outstanding reproducibility and selectivity in real-sample examination. Our study suggests that the rGO-PANI-PtNP/GCE may have broad utility in H2O2 detection under physiological and pathological conditions.

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Section: Introductionmentioning

confidence: 99%

A nanocomposite-based electrochemical sensor for non-enzymatic detection of hydrogen peroxide

Chen

Dong

et al. 2017

Oncotarget

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“…In 2015, Yu et al discovered that the luminol reaction could be catalyzed by iodophenol blue, providing a less expensive method for H 2 O 2 detection than the commonly used horseradish peroxidase (HRP) assays; the method also increased reproducibility compared to peroxidase-mimicking nanoparticle assays, whose detection properties depend on particle size [31].…”

Section: Developments From 2015 To 2019mentioning

confidence: 99%

“…In 2019, Wang et al decreased the H 2 O 2 detection limit of the luminol reaction via the synthesis and use of a hemin and poly(ethylene glycol) methyl ether catalyst [36]. The new catalyst resulted in a detection limit of 1.8 nM [36], lower than other luminol-H 2 O 2 detection levels [31,36,[43][44][45].…”

Section: Developments From 2015 To 2019mentioning

confidence: 99%

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Hydrogen Peroxide Sensors for Biomedical Applications

et al. 2019

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Hydrogen peroxide (H2O2) is an important molecule within the human body, but many of its roles in physiology and pathophysiology are not well understood. To better understand the importance of H2O2 in biological systems, it is essential that researchers are able to quantify this reactive species in various settings, including in vitro, ex vivo and in vivo systems. This review covers a broad range of H2O2 sensors that have been used in biological systems, highlighting advancements that have taken place since 2015.

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“…Therefore, many scientists have focused on the development of a new method for simple, fast, cheap, selective, sensitive accurate and reliable detection of H 2 O 2 [11‐45]. For this, various useful methods such as spectrophotometric , fluorimetric , chemiluminometric and electroanalytical methods have been proposed for H 2 O 2 determination. Among those, electroanalytical methods have found great attention due to its high sensitivity, ease of operation, and low cost .…”

Section: Introductionmentioning

confidence: 99%

Flow Injection Amperometric Analysis of H₂O₂ at Platinum Nanoparticles Modified Pencil Graphite Electrode

Karakaya

Dilgin

2017

Electroanalysis

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A Pt nanoparticle modified Pencil Graphite Electrode (PGE) was proposed for the electrocatalytic oxidation and non‐enzymatic determination of H2O2 in Flow Injection Analysis (FIA) system. Platinum nanoparticles (PtNPs) electrochemically deposited on pretreated PGE (p.PGE) surface by recording cyclic voltammograms of 1.0 mM of H2PtCl6 solution in 0.10 M KCl at scan rate of 50 mV s−1 for 30 cycles. Cyclic voltammograms show that the oxidation peak potential of H2O2 shifts from about +700 mV at bare PGE to +50 mV at PtNPs/p.PGE vs. Ag/AgCl /KCl (sat.). It can be concluded that PtNPs/p.PGE exhibits a good electrocatalytic activity towards oxidation of H2O2. Then, FI amperometric analysis of H2O2 was performed under optimized conditions using a new homemade electrochemical flow cell which was constructed for PGE. Linear range was found as 2.5 μM to 750.0 μM H2O2 with a detection limit of 0.73 μM (based on Sb/m of 3). As a result, this study shows the first study on the FI amperometric determination of H2O2 at PtNPs/p.PGE which exhibits a simple, low cost, commercially available, disposable sensor for H2O2 detection. The proposed electrode was successfully applied to determination of H2O2 in real sample.

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Iodophenol blue-enhanced luminol chemiluminescence and its application to hydrogen peroxide and glucose detection

Cited by 55 publications

References 35 publications

A nanocomposite-based electrochemical sensor for non-enzymatic detection of hydrogen peroxide

A nanocomposite-based electrochemical sensor for non-enzymatic detection of hydrogen peroxide

Hydrogen Peroxide Sensors for Biomedical Applications

Flow Injection Amperometric Analysis of H₂O₂ at Platinum Nanoparticles Modified Pencil Graphite Electrode

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Iodophenol blue-enhanced luminol chemiluminescence and its application to hydrogen peroxide and glucose detection

Cited by 55 publications

References 35 publications

A nanocomposite-based electrochemical sensor for non-enzymatic detection of hydrogen peroxide

A nanocomposite-based electrochemical sensor for non-enzymatic detection of hydrogen peroxide

Hydrogen Peroxide Sensors for Biomedical Applications

Flow Injection Amperometric Analysis of H2O2 at Platinum Nanoparticles Modified Pencil Graphite Electrode

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Flow Injection Amperometric Analysis of H₂O₂ at Platinum Nanoparticles Modified Pencil Graphite Electrode