Iohexol

Haria, Malini; Brogden, Rex N.

doi:10.2165/00023210-199707030-00006

Cited by 5 publications

(6 citation statements)

References 61 publications

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“…Recent studies suggest that iohexol distributes into tissues by simple diffusion due to concentration gradient. 30,31 As shown in showed the same results as CLSM (Figure 5B). The fluorescence intensity of FITC was quantified and presented as a bar graph (Figure 5C).…”

Section: Cip Cytotoxicity Studiessupporting

confidence: 76%

“…Cells were treated with FITC-CIP or FITC-iohexol to determine the cellular uptake patterns. Recent studies suggest that iohexol distributes into tissues by simple diffusion due to concentration gradient. , As shown in Figure A, fluorescence images show similar cellular uptake patterns of the CIP and iohexol in various cells. Both of contrast agents showed no specific uptake pattern and showed intracellular distribution by simple diffusion.…”

Section: Resultsmentioning

confidence: 65%

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Facile Hydrothermal Synthesis of an Iodine-Doped Computed Tomography Contrast Agent Using Insoluble Triiodobenzene

Jeong

Shin

2020

ACS Biomater. Sci. Eng.

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Carbonized iodine-doped particles (CIPs) were developed to overcome the disadvantages of computed tomography (CT) contrast agents, such as high osmolality and the radiodensity dilution of monomolecular contrast agents and low solubility and high toxicity of polymeric contrast agents. The CIPs were synthesized via a hydrothermal synthesis for 8 h using ATIPA (5-amino-2,4,6-triiodoisophthalic acid), glycerol, and tromethamine in the presence of D.W. (deionized water)-insoluble ATIPA converted into CIPs through a hydrothermal synthesis, showing high solubility and low osmotic pressure. The in vitro contrast effect determined for the resulting CIPs demonstrated a 57.6% enhancement compared to iohexol, and the osmotic pressure of the resulting CIPs was lower than that of iohexol. In addition, the CIPs demonstrated no dilution-induced contrast decrease in plasma and, therefore, demonstrated high contrast strength in vivo. Cytotoxicity tests, hemolysis assays, and histological analyses were conducted to verify the biocompatibility of the CIP product; however, no toxicity was observed. Furthermore, the CIP demonstrated a much higher contrast effect than iohexol at low concentrations. These results indicate that the CIP we have produced may be used as an effective blood pool agent for CT imaging.

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Section: Cip Cytotoxicity Studiessupporting

confidence: 76%

Section: Resultsmentioning

confidence: 65%

Facile Hydrothermal Synthesis of an Iodine-Doped Computed Tomography Contrast Agent Using Insoluble Triiodobenzene

Jeong

Shin

2020

ACS Biomater. Sci. Eng.

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“…In a study in rats, it was shown that iohexol does not bind to serotonin, dopamine D2, muscarinic, noradrenaline, opiate, N-methyl-D-aspartate (NMDA) receptors. Even at high concentrations, iohexol did not cause neurotoxic side effects [17]. Nygaard et al stated that the use of iohexol in patients with thyroid disease is safe [18].…”

Section: Resultsmentioning

confidence: 99%

Investigation of The Binding Potential of Gadobutrol, Iohexol and Fluorescein Radiocontrast Agents to the TSH Receptor

Karataş

Gonel

2022

J Intell Syst Appl

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Radiopaque agents can affect the human body in different ways. The resulting reactions are simple allergic and anaphylactic reactions. If the potential of these agents to bind to different receptors is determined beforehand, precautions can be taken against the side effects that may occur in the future. The aim of this study is to investigate the binding potential of the active substances Fluorescein, Gadobutrol, Iohexol, which are frequently used in routine, to the TSH receptor with molecular docking. The conformational analysis of 3 drugs on TSH receptor surfaces was performed by molecular docking using Autodocktools program. First, the atomic center of the receptor was determined at the grid stage, and the XYZ center of the grid box was set to 9.524, 48.24 and 25.257 A, respectively, and the space gap was set to 0.5. Thus, a box was created in which the ligand can easily scan the entire surface. In the docking phase, a parameter file has been prepared and run for 100 conformation and 300 population size, accompanied by Lamarckian and Genetic Algorithms. The binding energies of fluorescein, gadobutrol and iohexol strengthen the possibility of spontaneous binding. However, when the inhibition concentrations are evaluated, it shows that fluorescein can more easily bind to the TSH receptor. Gadobutrol and iohexol are unlikely to reach these concentrations in the blood. This in vitro study demonstrates the potential for spontaneous binding of fluorescein, gadobutrol, and iohexol to the TSH receptor. Even if radiopaque drugs are used for diagnostic purposes, they may cause side effects by interacting with different receptors in the human body. Experimental studies are needed to confirm this possibility.

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“…While every administration into the CSF cavity is invasive, contrast agents for CT and MRI are different from radiopharmaceuticals in terms of their chemical and pharmaceutical composition and the administered amounts. For example, for contrast-enhanced CT cisternography, an iodine containing agent is administered in high amounts of several hundred milligrams of iodine per milliliter [ 2 , 9 ]. Only one CT contrast agent, Iohexol (Omnipaque TM , GE Healthcare, Princeton, NJ, USA), is currently approved for intrathecal administration by the US Food and Drug administration (FDA) and the European Medicines Agency (EMA) and is generally considered to have a good safety profile, although reported adverse events include headaches, pain and aches, neck stiffness and nausea, and, albeit very rarely, seizures [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…For example, for contrast-enhanced CT cisternography, an iodine containing agent is administered in high amounts of several hundred milligrams of iodine per milliliter [ 2 , 9 ]. Only one CT contrast agent, Iohexol (Omnipaque TM , GE Healthcare, Princeton, NJ, USA), is currently approved for intrathecal administration by the US Food and Drug administration (FDA) and the European Medicines Agency (EMA) and is generally considered to have a good safety profile, although reported adverse events include headaches, pain and aches, neck stiffness and nausea, and, albeit very rarely, seizures [ 9 , 10 , 11 ]. The overall adverse event incidence has been reported to be 7.4% to 40% [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Radionuclide Cisternography with [64Cu]Cu-DOTA

Greiser,

Groeber,

Weisheit

et al. 2023

Pharmaceuticals

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Radionuclide cisternography (RNC) is a method for conducting imaging of the cerebrospinal system and can be used to identify cerebrospinal fluid leaks. So far, RNC has commonly employed radiopharmaceutical agents suitable only for single-photon emission tomography techniques, which are thus lacking in terms of image resolution and can potentially lead to false-negative results. Therefore, [64Cu]Cu-DOTA was investigated as an alternative radiopharmaceutical for RNC, employing positron emission tomography (PET) instead of single-photon emission tomography. A formulation of [64Cu]Cu-DOTA was produced according to the guidelines for good manufacturing practice. The product met the requirements of agents suitable for intrathecal application. [64Cu]Cu-DOTA was administered to a patient and compared to the approved scintigraphic RNC agent, [111In]In-DTPA. While no cerebrospinal fluid leak was detected with [111In]In-DTPA, [64Cu]Cu-DOTA RNC exhibited a posterolateral leak between the vertebral bodies C1 and C2. Thus, in this patient, PET RNC with [64Cu]Cu-DOTA was superior to RNC with [111In]In-DTPA. Since radiopharmaceuticals have a very good safety profile regarding the occurrence of adverse events, PET RNC with [64Cu]Cu-DOTA may become an attractive alternative to scintigraphic methods, and also to computed tomography or magnetic resonance imaging, which often require contrast agents, causing adverse events to occur much more frequently.

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Iohexol

Cited by 5 publications

References 61 publications

Facile Hydrothermal Synthesis of an Iodine-Doped Computed Tomography Contrast Agent Using Insoluble Triiodobenzene

Facile Hydrothermal Synthesis of an Iodine-Doped Computed Tomography Contrast Agent Using Insoluble Triiodobenzene

Investigation of The Binding Potential of Gadobutrol, Iohexol and Fluorescein Radiocontrast Agents to the TSH Receptor

Radionuclide Cisternography with [64Cu]Cu-DOTA

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