IOLs glistenings and quality of vision

Grzybowski, Andrzej; Kanclerz, Piotr; Beiko, George

doi:10.1007/s00417-019-04496-8

Cited by 13 publications

(10 citation statements)

References 10 publications

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“…It was proposed that the higher refractive power of IOL can be associated with higher severity of glistenings. However, we found three studies (44,46,83) that did not find the significant association between the IOLs power and the severity of glistenings and previously reported findings could be caused by the higher thickness of the material (24,42,45).…”

Section: Discussionmentioning

confidence: 54%

“…A higher refractive power of the intraocular lens and the use of bigger diameter cartridge during phacoemulsification were significantly related to the higher severity of glistening (45). The higher refractive power of the IOL can be associated with the increase in glistening severity due to the thicker IOL matrix and the higher amount of material (24,42). However, other studies did not find a correlation between the IOLs power and the number of glistening in hydrophobic AcrySof IOLs (44,46).…”

Section: Glisteningsmentioning

confidence: 97%

“…Glistenings are small fluid-filled vacuoles in the IOL material (Figure 1), which size usually varies between 1 and 20 μm (24). Microvacuoles refractive indices differ from IOL material, so when the light redirects and a portion of the light is scattered backward to the observer, it is seen as refractive particles that glisten on a slit lamp examination (1,20).…”

Section: Glisteningsmentioning

confidence: 99%

“…Glistening can be found in all IOL materials, including PMMA, silicone, and hydrophilic acrylic IOLs, but they are observed predominantly in hydrophobic acrylic lenses, which are one of the most commonly used (24,27,28,33). It was reported that glistening in hydrophobic acrylic lenses have higher density (16,33).…”

Section: Glisteningsmentioning

confidence: 99%

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A narrative review of intraocular lens opacifications: update 2020

Grzybowski¹,

Markeviciute²,

Žemaitienė³

2020

Ann Transl Med

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The opacifications of intraocular lenses (IOLs) can significantly impact patients visual quality.Despite the identification of specific risk factors, manufacturing changes, opacifications are not eliminated.Likewise, more attention in recent studies was paid to possible new risk factors, however one of the most important purposes of the studies remains opacifications effect on visual performance, which could be disturbed in different aspects. The aim of this review is to discuss the main risk factors of IOLs opacification in particular IOL types, and its impact on vision quality. Different risk factors were discussed in the study, including the material of IOLs, the impact of the breakdown of blood-aqueous barrier (BAB), and certain surgeries that can be associated with opacification formation. Glistenings occur more often in a hydrophobic material, however, the changes in water content of the IOLs can significantly reduce the formation of glistenings. The studies showed a significant effect of intraocular injection of exogenous air or gas during Descemet-stripping endothelial keratoplasty, Descemet-stripping automated endothelial keratoplasty, Descemet membrane endothelial keratoplasty, and pars plana vitrectomy on calcification formation. It raises a concern, as the incidence of these surgeries is increasing. Visual acuity decreases significantly after the calcification in IOLs occurs, and it usually causes IOLs exchange. However, disability glare seems to be more affected in patients with IOLs, which were affected by glistenings than visual acuity. Disability glare is associated with increased levels of straylight, which was widely evaluated in recent studies and it was reported to be a susceptible measurement to detect the presence of IOLs pathology. For future researches, it should be noticed that disability glare and straylight are more appropriate in evaluating IOLs opacification effect on visual quality than visual acuity. While reviewing the main risk factors of IOLs opacifications particular attention must be paid on calcification occurrence in hydrophilic acrylic IOLs after surgeries with intraocular injection of exogenous air or gas.

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Section: Discussionmentioning

confidence: 54%

Section: Glisteningsmentioning

confidence: 97%

Section: Glisteningsmentioning

confidence: 99%

Section: Glisteningsmentioning

confidence: 99%

See 2 more Smart Citations

A narrative review of intraocular lens opacifications: update 2020

Grzybowski¹,

Markeviciute²,

Žemaitienė³

2020

Ann Transl Med

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“…Foldable hydrophobic acrylic is one of most used IOL material, since it remains stable and leads to less severe inflammation and PCO (22). Hydrophobic acrylic IOLs have been associated with a higher incidence of glistening that might impair visual performance, after cataract extraction in adults (23). New glisteningfree material seems then suitable (24).…”

Section: Cataract Diagnosis and Managementmentioning

confidence: 99%

Recent developments in the management of congenital cataract

Brémond‐Gignac¹,

Daruich²,

Robert³

et al. 2020

Ann Transl Med

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Congenital cataract is a rare eye disease, one of the leading treatable causes of low vision in children worldwide. Hereditary cataracts can be divided in syndromic and non-syndromic cataracts. Early diagnosis in congenital cataracts is key to reach good visual function. Current surgical techniques, that combine microincision cataract extraction and primary intraocular lens (IOL) implantation, have improved childhood cataract outcome. Complications include posterior capsule opacification (PCO), aphakic or pseudophakic glaucoma, uveitis, pupil displacement and IOL decentration. A recent study using a modified Delphi approach identified areas of consensus and disagreement in the management of pediatric cataract. A consensus or near consensus was achieved for 79% of the questions, however 21% of the questions remained controversial, as for IOL implantation strategy. Congenital cataracts show a highly variable phenotype and genotype, and can be related to different mutations, genetic variance, and other risk factors. Congenital cataracts can be associated with other ocular developmental abnormalities, including microphthalmia, microcornea, or aniridia and with systemic findings. Next-generation sequencing (NGS) and forthcoming new ultra-high-throughput sequencing represent excellent tools to investigate the genetic causes of congenital cataracts. A better recognition of different clinical presentations and underlying etiologies of congenital cataracts may lead to the development of new approaches to improve visual outcome after cataract surgery and promote early detection of systemic associated syndromes.

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Effect of Hydrophobic Acrylic Monomers with Different Alkyl Side Chain Lengths on Reducing the Glistening of Hydrophobic Acrylic Intraocular Lens Materials

Kim,

Song

2024

ChemistrySelect

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Glistening is the condensation of water that forms within the intraocular lens (IOL) materials. In this study, a new approach was attempted to reduce the glistening of IOL materials by introducing hydrophobic acrylic monomers with different alkyl side chain lengths into the IOL materials. Various hydrophobic acrylic monomers such as butyl acrylate (BA), 2‐ethylhexyl acrylate (EHA), and dodecyl acrylate (DA) were copolymerized with a hydrophobic acrylic monomer, 2‐phenoxyethyl acrylate, respectively. In this process, we investigated the effect of the alkyl side chain lengths of hydrophobic acrylic monomers on the glistening of hydrophobic acrylic IOL materials. As the content of hydrophobic acrylic monomers (BA, EHA, and DA) increased, the glistening of IOL materials decreased significantly for all hydrophobic acrylic monomers. At the same content of hydrophobic acrylic monomers, the IOL material showed the least content of glistening when copolymerized with DA. However, the IOL material obtained using BA exhibited the largest content of glistening, indicating that the glistening reduction effect was large in the order of DA>EHA>BA. These findings show that the glistening of IOL materials decreases with increasing alkyl side chain lengths of hydrophobic acrylic monomers.

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IOLs glistenings and quality of vision

Cited by 13 publications

References 10 publications

A narrative review of intraocular lens opacifications: update 2020

A narrative review of intraocular lens opacifications: update 2020

Recent developments in the management of congenital cataract

Effect of Hydrophobic Acrylic Monomers with Different Alkyl Side Chain Lengths on Reducing the Glistening of Hydrophobic Acrylic Intraocular Lens Materials

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