2021
DOI: 10.3390/ani11123379
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Ion Channel and Ubiquitin Differential Expression during Erythromycin-Induced Anhidrosis in Foals

Abstract: Macrolide drugs are the treatment of choice for Rhodococcus equi infections, despite severe side-effects temporary anhidrosis as a. To better understand the molecular biology leading to macrolide induced anhidrosis, we performed skin biopsies and Quantitative Intradermal Terbutaline Sweat Tests (QITSTs) in six healthy pony-cross foals for three different timepoints during erythromycin administration—pre-treatment (baseline), during anhidrosis and post-recovery. RNA sequencing of biopsies followed by differenti… Show more

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“…What is more, macrolide-induced anhidrosis may present even greater peril. These reactions in certain foals are connected with ion channels and β 2 -adrenergic receptors, but the proceedings and prognosis in such incidents are still not settled [33,34]. Up to date, in case of such antimicrobial adverse effects, the only solution implemented in cooperating studs relies on careful monitoring of the foals by appropriately qualified and responsible stable staff and their minute fulfilment of the recommendations.…”
Section: Discussionmentioning
confidence: 99%
“…What is more, macrolide-induced anhidrosis may present even greater peril. These reactions in certain foals are connected with ion channels and β 2 -adrenergic receptors, but the proceedings and prognosis in such incidents are still not settled [33,34]. Up to date, in case of such antimicrobial adverse effects, the only solution implemented in cooperating studs relies on careful monitoring of the foals by appropriately qualified and responsible stable staff and their minute fulfilment of the recommendations.…”
Section: Discussionmentioning
confidence: 99%