Ion Channels in The Pathogenesis of Endometriosis: A Cutting-Edge Point of View

Riemma, Gaetano; Laganà, Antonio Simone; Schiattarella, Antonio; Garzon, Simone; Cobellis, Luigi; Autiero, Raffaele; Licciardi, Federico; Corte, Luigi Della; Verde, Marco La; Franciscis, Pasquale De

doi:10.3390/ijms21031114

Cited by 38 publications

(31 citation statements)

References 87 publications

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“…However, we did not collect the data on endometriosis. This must be considered an unmeasured confounder in the present study, since endometriosis is an estrogen-dependent disease that affects women in reproductive age 8 , 9 and is correlated with a risk of hypertension, placenta previa, and low newborn weight. We should consider investigating this point in a future paper.…”

Section: Resultsmentioning

confidence: 99%

Moderate rate of implementation of spinal anesthesia for cesarean section: does it improve neonatal well-being? A case–control study

Kubota

Niwa

Hirota

2021

Sci Rep

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Before 2013, almost none of the cesarean section (CS) deliveries at our institution were performed with spinal anesthesia (SA), but after 2013 SA became the first-choice anesthesia for CS because it achieved better neonatal outcomes. However, the current rate of SA implementation at our institution was estimated to be approx. 60–70%, which is intermediate between these at other institutions in Japan or in other countries. This raises a question: What rate of SA use among CS cases achieves the best neonatal outcomes? To answer this question, we conducted this single-center case–control study with 1326 CS cases between 1994 and 2017 and compared the neonatal outcomes before to those after 2013. The logistic regression models were prepared to estimate the risk of birth asphyxia defined as a 5-min Apgar of < 7, associated with eight potential confounders, including the modified anesthetic protocol. The modified protocol was not a significant independent factor for neonatal asphyxia, indicating that our moderate SA priority protocol did not improve the neonatal outcomes even when compared to the outcomes at a 0% SA rate. A > 70% rate of SA implementation may be needed to provide better neonatal outcomes.

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Section: Resultsmentioning

confidence: 99%

Moderate rate of implementation of spinal anesthesia for cesarean section: does it improve neonatal well-being? A case–control study

Kubota

Niwa

Hirota

2021

Sci Rep

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“…Although CA125 has consistently been reported to be associated with endometriosis, many prior studies combined patients with diverse clinical phenotypes and categorized endometriosis as one disease [5,6,9]. In fact, recent studies support that multiple molecular mechanisms are involved in endometriosis pathogenesis, including the complex genetic nature and epigenetic mechanisms influencing hormonal, immunologic, and inflammatory aberrations in endometriosis patients [27,28]. The heterogeneous presentation and molecular mechanisms underlying endometriosis suggest different etiological pathways by subtypes and combining these subtypes into a single endometriosis definition in prior studies may have thwarted progress in finding a reproducible endometriosis biomarker, as a clear signal with any given subtype being overwhelmed by the differences between subtypes [17].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of CA125 in relation to pain symptoms among adolescents and young adult women with and without surgically-confirmed endometriosis

et al. 2020

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Endometriosis is a painful gynecologic disease affecting one in ten reproductive aged women worldwide. Few studies have correlated this symptomatology with biomarker levels among women with and without endometriosis, and no studies correlating pain with biomarker levels have been performed in young patient populations. The purpose of this study was to examine whether CA125 correlates with different types and severity of pain among adolescents and young women with and without endometriosis and assess its performance as an endometriosis biomarker among those presenting with dysmenorrhea in this young population. Reproductive-aged women with laparoscopically-confirmed endometriosis (n = 282) and controls (n = 293) who participated in The Women's Health Study: From Adolescence to Adulthood (A2A), a cohort of adolescents and young women enrolled from 2012-2018, were included in this cross-sectional analysis. Plasma CA125 values were measured using WERF EPHect compliant blood samples collected at enrollment. Average CA125 were calculated by self-reported pain type (i.e. dysmenorrhea, non-cyclic/general pelvic pain, dyspareunia), severity, and frequency in endometriosis cases and controls. Median age at blood draw was 24 years in controls and 17 years in cases, with 68% and 89% non-Hispanic white, respectively. Most endometriosis cases (95%) were rASRM stage I/II. Average CA125 values were 12.5 U/mL in controls and 12.1 U/mL in cases adjusted for age. CA125 did not differ by pain type, its severity, or frequency in endometriosis cases or controls. Among participants who reported dysmenorrhea, CA125 did not discriminate endometriosis cases from controls using cutoff of 35 U/mL (AUC = 0.51, 95%CI = 0.50-0.53). Among adolescents and young adult women, CA125 did not correlate with pain type. CA125

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“…Currently, it is unclear if these results vary depending upon infertility etiology and the types of ovarian stimulation protocol and ovarian response. This is also true when there are accompanying ovarian pathology or other disease that may alter ovarian response to stimulation such as endometriosis, which is a complex disease with genetic, epigenetic and immunologic aberrations [20][21][22] . Diminished ovarian reserve or poor response to stimulation are commonly observed in patients with endometriosis undergoing ovulation induction or ovarian stimulation 22,23 .…”

Section: Discussionmentioning

confidence: 99%

There is a cycle to cycle variation in ovarian response and pre-hCG serum progesterone level: an analysis of 244 consecutive IVF cycles

Yıldız

Yakın

Ata

et al. 2020

Sci Rep

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We aimed to answer one key question, that was not previously addressed as to whether serum progesterone (P4-hCG day) and its co-variates (estradiol (E2-hCG day) and the number of retrieved oocytes) of a given cycle can be predictive of the subsequent cycle when both cycles are consecutive and comparable for the stimulation protocol, gonadotropin dose and duration of stimulation. We analyzed such 244 consecutive (< 6 months) IVF cycles in 122 patients with GnRH agonist long protocol and found that P4, E2 and the number of retrieved oocytes significantly vary between the two cycles. Although P4 increased (ranging from 4.7 to 266.7%) in the 2nd cycle in 61 patients, E2 and the number of retrieved oocytes, which are normally positively correlated with P4 paradoxically decreased in the 41% and 37.7% respectively, of these same 61 patients. When a similar analysis was done in the 54 out of 122 patients (44.3%) in whom serum P4 was decreased in the 2nd cycle, the mean decrease in P4 was − 34.1 ± 23.3% ranging from − 5.26 to − 90.1%. E2 and the number of retrieved oocytes paradoxically increased in the 42.3% and 40.7% of these 54 patients respectively. P4 remained the same only in the 7 (5.7%) of these 122 patients. These findings indicate that late follicular phase serum P4 may change unpredictably in the subsequent IVF cycle. The changes are not always necessarily proportional with ovarian response of previous cycle suggesting that growth characteristics and steroidogenic activities of antral cohorts may exhibit considerable cycle to cycle variations.

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Ion Channels in The Pathogenesis of Endometriosis: A Cutting-Edge Point of View

Cited by 38 publications

References 87 publications

Moderate rate of implementation of spinal anesthesia for cesarean section: does it improve neonatal well-being? A case–control study

Moderate rate of implementation of spinal anesthesia for cesarean section: does it improve neonatal well-being? A case–control study

Evaluation of CA125 in relation to pain symptoms among adolescents and young adult women with and without surgically-confirmed endometriosis

There is a cycle to cycle variation in ovarian response and pre-hCG serum progesterone level: an analysis of 244 consecutive IVF cycles

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