2022
DOI: 10.3390/ijms23115880
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Ion Channels of Spermatozoa: Structure, Function, and Regulation Mechanisms

Abstract: Ion transport is essential for sperm physiology, being involved in sperm-cell differentiation and maturation, motility activation, chemotaxis towards the oocyte, and fertilization, as well as in sperm adaptation to the surrounding medium [...]

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Cited by 3 publications
(3 citation statements)
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“…This is only one of the many examples on the functional relationship between different ion channel activities that support sperm activity and fertility potential. This evidence is further corroborated by experiments in which the inhibition or dysfunction of even only one channel type results in a reduced or impaired fertilization rate [ 42 , 43 ]. Until 2006, studies on the ion current activities in spermatozoa relied on the use of pharmacology and voltage- and ion-sensitive fluorescent probes, such as Ca 2+ and H + indicators that, however, gave uncertain results based on weak signals emitted [ 44 , 45 ].…”
Section: Electrophysiologymentioning
confidence: 65%
“…This is only one of the many examples on the functional relationship between different ion channel activities that support sperm activity and fertility potential. This evidence is further corroborated by experiments in which the inhibition or dysfunction of even only one channel type results in a reduced or impaired fertilization rate [ 42 , 43 ]. Until 2006, studies on the ion current activities in spermatozoa relied on the use of pharmacology and voltage- and ion-sensitive fluorescent probes, such as Ca 2+ and H + indicators that, however, gave uncertain results based on weak signals emitted [ 44 , 45 ].…”
Section: Electrophysiologymentioning
confidence: 65%
“…The importance of the physiological role of sperm ion channels and the effect of cryopreservation in mammalian species have been revealed to some extent 109 . However, there are few studies dealing with the effect of these channels on sperm cryotolerance, or the relationship between them 97 .…”
Section: Discussionmentioning
confidence: 99%
“…These researchers both suggest that voltage-dependent anion channel might be a biomarker to predict the freezability and select high cryo-tolerant sperm 108,110 . Despite these studies, the effect of various ion channels on cryotolerance still needs to be clari ed 97,109 .…”
Section: Discussionmentioning
confidence: 99%