Ion chromatography of methanesulfonic acid in pharmaceuticals

Development of a simple method for quantitation of methanesulfonic acid at low ppm level using hydrophilic interaction chromatography coupled with ESI-MS

“…0.02 g/mL or 1 ppm relative to 20 mg/mL sample concentration of Intermediate A. Previously, Annable et al and Jagota et al reported QLs for MSA at levels of 40 ppm and 300 ppm (relative to sample concentration), respectively, using IC coupled with conductivity detection [9,10]. Quattrocchi et al analyzed MSA using IC-UV which provided the QL of 150 ppm [11].…”

“…(2) Alkyl sulfonic acids do not have a UV chromophore suitable for detection in LC. (3) Ion chromatography (IC), which is usually used for sulfonic acid determination [9][10][11], may not be employed when the sample matrix contains various ionic impurities. (4) In addition to LC methodologies, employment of headspace GC or GC-MS is not preferred because it requires sample pretreatment due to the poor volatility and strong acidity of sulfonic acids.…”

Determination of organic impurities in pharmaceutical preparations

“…Possible sources of inorganic impurities are catalysts, drying a gents, adsorbents, solvents, and equipment used in the production of the medicinal remedy, and raw materials. Inorganic impurities are commonly determined by spectrometric methods, most frequently atomic absorption spectrometry [8,9], as well as capillary ion electrophoresis [10,11], ion chromatography [12], and electrochemical methods [13 − 15]. However, the most difficult problem is the determination of organic impurities.…”

Determination of organic impurities in pharmaceutical preparations

“…Inorganic impurities are commonly determined by spectrometric methods, most frequently atomic absorption spectrometry [8,9], as well as capillary ion electrophoresis [10,11], ion chromatography [12], and electrochemical methods [13 − 15]. Chemical impurities can be of either organic or inorganic nature.…”