Ion distribution profiles in the drift region of an ion mobility spectrometer

Detection of Nitro-Based and Peroxide-Based Explosives by Fast Polarity-Switchable Ion Mobility Spectrometer with Ion Focusing in Vicinity of Faraday Detector

“…Among these, Eiceman and Davila et al experimentally measured the radial ion density profiles in the 63 Ni ionization IMS using a charge accumulation IonCCD detector with imaging capability of 2126 pixels at each 21 μm width, suggesting that the ion density was highest at the center of detector while declined radially 19 21 . However, this result was in contradiction with the work by Karpas et al 24 in which the ion density at the center of detector was lower than its outer parts. Tabrizchi et al 23 and Kwasnik et al 20 measured the radial ion density profiles in the drift tube using corona discharge ion source, and the ion density profiles were qualitatively similar to the observation of drift tube using electrospray ionization ion source by Hill et al 22 .…”

“…To improve the resolving power of an IMS, the radial distribution of ions in the drift tube is of valuable information, as it essentially determines the IMS spectrum. Up to date, several works have been carried out to investigate the radial distribution of ions in the drift tube with different ion sources 19 20 21 22 23 24 . Among these, Eiceman and Davila et al experimentally measured the radial ion density profiles in the 63 Ni ionization IMS using a charge accumulation IonCCD detector with imaging capability of 2126 pixels at each 21 μm width, suggesting that the ion density was highest at the center of detector while declined radially 19 21 .…”

Experimental Evaluation and Optimization of Structures for Lossless Ion Manipulations for Ion Mobility Spectrometry with Time-of-Flight Mass Spectrometry

“… 52 , 53 A key challenge, however, is the loss of sensitivity due to radial diffusion of the ions and, for example, Coulombic repulsion, into the electrode surfaces or other surfaces present in the system. 49 , 54 …”

“…52,53 A key challenge, however, is the loss of sensitivity due to radial diffusion of the ions and, for example, Coulombic repulsion, into the electrode surfaces or other surfaces present in the system. 49,54 Several approaches have been introduced for increasing the sensitivity of IMS/MS measurements. One was the implementation of the electrodynamic ion funnel after IMS analysis.…”

Ion Distribution Profiling in an Ion Mobility Spectrometer by Laser-Induced Fluorescence

“…Another example, as there are often complex processes of physical and chemical changes in the ionization region, it is difficult to build an accurate and complete simulation model for this region. As a result, experimentally profiling methods have received widespread attention for years , in exploring the ion motion and optimizing the simulation accuracy. Ion distributions of 63 Ni, ESI, nano-ESI, , and corona discharge were measured in experiment.…”